Adenosine Receptors and Parkinson's Disease

Adenosine Receptors and Parkinson's Disease

Author: Hiroshi Kase

Publisher: Academic Press

Published: 1999-10-15

Total Pages: 306

ISBN-13:

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This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease. Discusses the discovery and development of a novel non-dopaminomimetic agent for Parkinson's disease Provides the first definitive overview of adenosine antagonists and their role in the treatment of Parkinson's disease Presents a new mechanism of action of adenosine A2A receptor antagonists in motor function Proposes a hypothesis of adenosine A2A receptor function in the striatum Comprehensive overview of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, physiology, pharmacology, and neurochemistry viewpoints


Adenosine Receptors in Health and Disease

Adenosine Receptors in Health and Disease

Author: Constance N. Wilson

Publisher: Springer Science & Business Media

Published: 2009-07-28

Total Pages: 656

ISBN-13: 3540896155

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Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.


The Adenosine Receptors

The Adenosine Receptors

Author: Pier Andrea Borea

Publisher: Humana Press

Published: 2018-07-28

Total Pages: 603

ISBN-13: 3319908081

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This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.


Atlas of Neuroactive Substances and Their Receptors in the Rat

Atlas of Neuroactive Substances and Their Receptors in the Rat

Author: Masaya Tohyama

Publisher:

Published: 1998

Total Pages: 364

ISBN-13:

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The rat is probably the most widely used experimental system in neurobiology. Several anatomical atlases of the rat's nervous system already exist, but this atlas is unique in that it maps the distribution of all neuroactive substances--transmitters, growth factors, modulators, hormones, and peptides--and their receptors by brain region. It begins with a useful overview of neurotransmission mechanisms. The entire brain is then presented in highly visual three-color sections. The atlas covers the synthesis, distribution, and functions of each class of substances in intricate detail. The authors follow this with an analysis of the structure, subtypes, and distribution of receptors. The volume will be an invaluable reference work for all researchers in neuropharmacology, neurobiology, and neuropathology.


Homeostatic Control of Brain Function

Homeostatic Control of Brain Function

Author: Detlev Boison

Publisher: Oxford University Press

Published: 2016

Total Pages: 657

ISBN-13: 0199322295

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Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.


Adenosine Receptors in Neurology and Psychiatry

Adenosine Receptors in Neurology and Psychiatry

Author:

Publisher: Academic Press

Published: 2014-08-28

Total Pages: 523

ISBN-13: 0128013184

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This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on adenosine receptor science, providing insights useful for actual drug discovery/development in neurology and psychiatry areas. - Expertise of contributors - Subject including practical drug development from basic science, as translational research taste - Structure of contents focusing on two CNS areas for diseases (neurology and psychiatry)


Adenosine Receptors in Neurodegenerative Diseases

Adenosine Receptors in Neurodegenerative Diseases

Author: David Blum

Publisher: Academic Press

Published: 2017-03-30

Total Pages: 0

ISBN-13: 9780128037249

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Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field. Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience.


Etiology of Parkinson's Disease

Etiology of Parkinson's Disease

Author: Jonas H. Ellenberg

Publisher: CRC Press

Published: 1995-03-01

Total Pages: 600

ISBN-13: 9780824788230

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This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.


Frontiers in Pharmacology of Neurotransmitters

Frontiers in Pharmacology of Neurotransmitters

Author: Puneet Kumar

Publisher: Springer Nature

Published: 2020-10-29

Total Pages: 729

ISBN-13: 9811535566

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Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.


Nuclear Cardiology

Nuclear Cardiology

Author: Barry L. Zaret

Publisher:

Published: 1999

Total Pages: 704

ISBN-13:

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This latest edition of NUCLEAR CARDIOLOGY provides up-to-the-minute information on current and future uses of radionuclides in imaging diagnosis of the heart. Thoroughly revised and updated, it contains practical information on radiopharmaceuticals, tracer kinetics, instrumentation, ventricular function, perfusion, acute ischemic syndrome, viability, and metabolic images, as well as a discussion of the role of nuclear cardiology in a changing health care system. Practitioners in nuclear medicine, radiology, and cardiology will benefit from having current information on a wide range of topics in one focused reference. Provides highly detailed and comprehensive information in one convenient resource Includes more than 600 images and illustrations to aid comprehension Incorporates the knowledge of internationally recognized authors who are experts in the field Discusses a broad spectrum of nuclear cardiology applications to help you gain a better perspective on contemporary cardiac nuclear medicine