Author: Michael Egholm

Publisher: Taylor & Francis

Published: 1999-05

Total Pages: 284

ISBN-13:

Peptide Nucleic Acid (PNA) is an analogue of DNA in which the backbone is a pseudopeptide rather than a sugar. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands. The neutral backbone of PNA results in stronger binding and greater specificity than normally achieved. In addition, the unique chemical, physical and biological properties of PNA have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecues and biosensors. Important new applications have emerged that could not be performed using oligonucleotides. This book contains state-of-the-art protocols and applications on all aspects of Peptide Nucleic Acids. Concepts are explained clearly and in practical terms and each chapter contains concise background information. Written by leading experts in the field, the book is an invaluable and complete reference work on this novel and exciting area. An essential text for all molecular biologists, biochemists, geneticists, biotechnologists and nucleic acid chemists wishing to keep up with the latest developments.