A Novel Dual Modeling Method for Characterizing Human Nerve Fiber Activation

A Novel Dual Modeling Method for Characterizing Human Nerve Fiber Activation

Author: Frank Daniel Sugden

Publisher:

Published: 2014

Total Pages: 108

ISBN-13:

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Presented in this work is the investigation and successful illustration of a coupled model of the human nerve fiber. SPICE netlist code was utilized to describe the electrical properties of the human nervous membrane in tandem with COMSOL Multiphysics, a finite element analysis software tool. The initial research concentrated on the utilization of the Hodgkin-Huxley electrical circuit representation of the nerve fiber membrane. Further development of the project identified the need for a linear circuit model that more closely resembled the McNeal linearization model augmented by the work of Szlavik which better facilitated the coupling of both SPICE and COMSOL programs. Related literature was investigated and applied to validate the model. This combination of analysis tools allowed for the presentation of a consistent model and revealed that a coupled model produced not only a qualitatively comparable, but also a quantitatively comparable result to studies presented in the literature. All potential profiles produced during the simulation were compared against the literature in order to meet the purpose of presenting an advanced computational model of human neural recruitment and excitation. It was demonstrated through this process that the correct usage of neuron models within a two dimensional conductive space did allow for the approximate modeling of human neural electrical characteristics.


Handbook of Research on Nano-Drug Delivery and Tissue Engineering

Handbook of Research on Nano-Drug Delivery and Tissue Engineering

Author: Rajakumari Rajendran

Publisher: CRC Press

Published: 2022-03-10

Total Pages: 650

ISBN-13: 1000369536

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With contributions from leading researchers in the nanomedicine field from industry, academia, and government and private research institutions across the globe, the volume provides an up-to-date report on topical issues in nano-drug delivery and nanotechnological approaches to tissue engineering. The volume offers research on a variety of diverse nano-based drug delivery systems along with discussions of their efficacy, safety, toxicology, and applications for different purposes. Focusing on nanotechnology approaches to tissue engineering, this volume considers the use of hydrogel systems, nanoceria and micro- and nano-structured biomaterials for bone tissue engineering, mesenchymal stem cells, and more.


Bioelectronic Medicine

Bioelectronic Medicine

Author: Valentin A. Pavlov

Publisher: Perspectives Cshl

Published: 2019

Total Pages: 350

ISBN-13: 9781621823025

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"Cold Spring Harbor perspectives in medicine."


The NEURON Book

The NEURON Book

Author: Nicholas T. Carnevale

Publisher: Cambridge University Press

Published: 2006-01-12

Total Pages: 399

ISBN-13: 1139447831

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The authoritative reference on NEURON, the simulation environment for modeling biological neurons and neural networks that enjoys wide use in the experimental and computational neuroscience communities. This book shows how to use NEURON to construct and apply empirically based models. Written primarily for neuroscience investigators, teachers, and students, it assumes no previous knowledge of computer programming or numerical methods. Readers with a background in the physical sciences or mathematics, who have some knowledge about brain cells and circuits and are interested in computational modeling, will also find it helpful. The NEURON Book covers material that ranges from the inner workings of this program, to practical considerations involved in specifying the anatomical and biophysical properties that are to be represented in models. It uses a problem-solving approach, with many working examples that readers can try for themselves.


Computational Models of the Auditory System

Computational Models of the Auditory System

Author: Ray Meddis

Publisher: Springer Science & Business Media

Published: 2010-06-16

Total Pages: 290

ISBN-13: 1441959343

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The Springer Handbook of Auditory Research presents a series of comprehensive and synthetic reviews of the fundamental topics in modern auditory research. The v- umes are aimed at all individuals with interests in hearing research including advanced graduate students, post-doctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in pe- reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beg- ning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.


Methods of Behavior Analysis in Neuroscience

Methods of Behavior Analysis in Neuroscience

Author: Jerry J. Buccafusco

Publisher: CRC Press

Published: 2000-08-29

Total Pages: 341

ISBN-13: 1420041819

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Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic


Assessments, Treatments and Modeling in Aging and Neurological Disease

Assessments, Treatments and Modeling in Aging and Neurological Disease

Author: Colin R Martin

Publisher: Academic Press

Published: 2021-06-01

Total Pages: 608

ISBN-13: 0128180013

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Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer's, stroke and multiple sclerosis. - Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging - Features sections on diagnosis and biomarkers of neurological aging, Alzheimer's and stroke - Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables


Conn's Translational Neuroscience

Conn's Translational Neuroscience

Author: P. Michael Conn

Publisher: Academic Press

Published: 2016-09-28

Total Pages: 778

ISBN-13: 0128025964

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Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment


Index Medicus

Index Medicus

Author:

Publisher:

Published: 2004

Total Pages: 1876

ISBN-13:

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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.