A History of Transplantation Immunology
A History of Transplantation Immunology

Author: Leslie Brent

Publisher: Academic Press

Published: 1996-11-18

Total Pages: 506

ISBN-13: 008053399X

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Those entering the field of transplantation are frequently unaware of the topics historical roots and even of the background on which modern discoveries in tolerance, histocompabatibility antigens, and xenotransplantation are based. A History of Transplantation Immunology is an account, written by one of the founding fathers of the field, of how tissue and organ transplantation has become one of the most successful branches of late 20th century medicine. The book helps place the work of contemporary scientists into its proper context and makes fascinating reading for immunologists in all stages of their career. - Describes landmarks in immunology and places them in historical context - Beautifully written by one of the founding fathers of the field - Portrays the surprising history of events in a colorful and readable manner - Contains biographical sketches of some of the pioneers - Illustrates the development of key ideas in immunology--tolerance, graft rejection, and transplantation - Foreword by Ray Owen

A History of Organ Transplantation
A History of Organ Transplantation

Author: David Hamilton

Publisher: University of Pittsburgh Pre

Published: 2013-12-21

Total Pages: 577

ISBN-13: 0822977842

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A History of Organ Transplantation is a comprehensive and ambitious exploration of transplant surgery—which, surprisingly, is one of the longest continuous medical endeavors in history. Moreover, no other medical enterprise has had so many multiple interactions with other fields, including biology, ethics, law, government, and technology. Exploring the medical, scientific, and surgical events that led to modern transplant techniques, Hamilton argues that progress in successful transplantation required a unique combination of multiple methods, bold surgical empiricism, and major immunological insights in order for surgeons to develop an understanding of the body's most complex and mysterious mechanisms. Surgical progress was nonlinear, sometimes reverting and sometimes significantly advancing through luck, serendipity, or helpful accidents of nature. The first book of its kind, A History of Organ Transplantation examines the evolution of surgical tissue replacement from classical times to the medieval period to the present day. This well-executed volume will be useful to undergraduates, graduate students, scholars, surgeons, and the general public. Both Western and non-Western experiences as well as folk practices are included.

Transplant Immunology
Transplant Immunology

Author: Xian C. Li

Publisher: John Wiley & Sons

Published: 2015-11-16

Total Pages: 363

ISBN-13: 0470658215

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With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area. Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation. Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field. Key chapters include: Transplant-related complications Immune responses to transplants Emerging issues in transplantation Biomarkers of Allograft rejection and tolerance T cells and the principles of immune responses In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.

Cellular Transplantation
Cellular Transplantation

Author: Craig Halberstadt

Publisher: Elsevier

Published: 2011-10-10

Total Pages: 699

ISBN-13: 0080469043

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There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. - Provides detailed description of clinical trials in cell transplantation - Review of current therapeutic approaches - Coverage of the broad range of diseases addressed by cell therapeutics - Discussion of stem cell biology and its role in transplantation

A History of Immunology
A History of Immunology

Author: Arthur M. Silverstein

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 445

ISBN-13: 0080925839

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This is a professional-level intellectual history of the development of immunology from about 1720 to about 1970. Beginning with the work and insights of the early immunologists in the 18th century, Silverstein traces the development of the major ideas which have formed immunology down to the maturation of the discipline in the decade following the Second World War. Emphasis is placed on the philosophic and sociologic climate of the scientific milieu in which immunology has developed, providing a background to the broad culture of the discipline. - A professional-level intellectual history of the development of immunology from about 1720 to 1970, with emphasis placed on the social climate of the scientific milieu in which modern immunology evolved - Written by an author very well known both as a historian of medical science and for his substantial research contributions to the immunopathology of the eye - The only complete history of immunology available

Transplantation Immunology: Methods and Protocols
Transplantation Immunology: Methods and Protocols

Author: Kayla Streep

Publisher:

Published: 2020-09-22

Total Pages: 248

ISBN-13: 9781632418692

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Transplantation refers to the process of moving cells, tissues or organs from one part of the body to another, whether within the same person, or between a donor and a recipient. It is usually a life-saving intervention and is a major operation. However, the transplanted tissue or organ may be rejected by the immune system. Rejection is an adaptive immune response of the body that can occur due to the mechanisms of cellular immunity or humoral immunity. Different transplanted tissues favor different rejection mechanisms. Acute rejection occurs in all transplants unless immunosuppression has been achieved. An exception to this is transplantation between identical twins. Hyperacute rejection response sets in within minutes after a transplant, which if unattended may trigger a systemic inflammatory response syndrome. Rapid clumping, particularly the agglutination of red blood cells, is a common risk in kidney transplants. Chronic rejection can arise when there is a long-term loss of function in the transplanted organ. This loss in function arises due to fibrosis of the blood vessels of the transplanted tissues. This is responsible for the long-term morbidity witnessed in lung-transplant recipients. Transplant rejection can be lowered by using immunosuppressant drugs after transplantation and by prior determination of the molecular similitude between donor and recipient. This book provides comprehensive insights into the field of transplantation immunology. It presents researches and studies performed by experts across the globe on the methods and protocols of transplantation. It is a vital tool for all researching and studying this field.

A Historical Perspective on Evidence-Based Immunology
A Historical Perspective on Evidence-Based Immunology

Author: Edward J. Moticka

Publisher: Newnes

Published: 2015-11-25

Total Pages: 396

ISBN-13: 0123983754

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A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. - Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles - Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology - Presents concepts such as the division of lymphocytes into functionally different populations in their historical context - Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

Oxford Textbook of Fundamentals of Surgery
Oxford Textbook of Fundamentals of Surgery

Author: William E. G. Thomas

Publisher: Oxford University Press

Published: 2016

Total Pages: 849

ISBN-13: 0199665540

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A definitive, accessible, and reliable resource which provides a solid foundation of the knowledge and basic science needed to hone all of the core surgical skills used in surgical settings. Presented in a clear and accessible way it addresses the cross-specialty aspects of surgery applicable to all trainees.

Thomas' Hematopoietic Cell Transplantation
Thomas' Hematopoietic Cell Transplantation

Author: Stephen J. Forman

Publisher: John Wiley & Sons

Published: 2015-12-14

Total Pages: 1416

ISBN-13: 1118416120

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Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.