Groff Conklin was the most important science fiction anthologist through the years of the genre's true second generation, that point at which its previously magazine-bound masterpieces were being systemtically located, aligned and placed into permanent format. His contribution over the period of two decades was irreplaceable and all of our postwar history exists in the penumbra of his work. Bud Webster has in this index granted an act of scholarship and homage of equal irreplaceability. - Barry Malzberg, author and editor
The second Dodie Fanshaw mystery by Marina Oliver, author of 80+ novels. Dodie's rural peace is shattered, first by a mermaid walking up the lawn from the river Thames, and then by a body near the pool. The body belonged to an author who lived next door. His girlfriend, publisher and agent, ex-lovers and neighbours crowd the garden. But who might have killed this best-selling novelist? And why? Inevitably Dodie is drawn into trying to solve the mystery.
Thousands of hours of research have culminated in this First Edition of U.S. Navy, U.S. Marine Corps, U.S. Coast Guard and Naval Air Transport Service patrol aircraft lost or damaged during World War II. Within these 600+ pages can be found more than 2,200 patrol aircraft across nearly 300 squadron designations; the majority of the aircraft complete with their stories of how they were lost or damaged or simply Struck Off Charge (SOC) and removed from the Navy's inventory. Of interest to the reader may be the alphabetical Index to the 7,600+ names of Officers, aircrewmen and others mentioned in the book.
Because of the prominence of prophecy in Scripture, many excellent books have appeared dealing with prophetic subjects. Until recently, however, the treatment of prophecy has been either apologetic or expository, and prophetic themes have been developed individually apart from their relation to the whole revealed prophetic program. Much of our knowledge has been only fragmentary and unrelated. Dr. Dwight Pentecost’s monumental text, Things to Come, has changed all that. In this massive, highly successful book, Dr. Pentecost has synthesized the whole field of prophecy into a unified biblical doctrine, a systematic and complete biblical eschatology. With nearly a quarter of a million copies sold, Things to Come has earned its place in the library of the pastor, the scholar, and the seminarian or Bible institute student. In addition, it offers a comprehensive and accessible study for anyone interested in the important subject of biblical prophecy.
Key words and contexts retain the original spelling of the first edition, but all words are cross-referenced to variant and modern spellings - one of many features that make this volume a necessary companion to any edition of Bradstreet's work.
Diabetic cardiomyopathy is a clinical condition of heart dysfunction that develops in the absence of hypertension and coronary atherosclerosis in diabetic patients. The main characteristics of diabetic cardiomyopathy are myocardial fibrosis, cardiac stiffness, left ventricular hypertrophy and decreased left ventricular compliance. This eventually progresses to clinical heart failure with reduced ejection fraction. To detect changes in cardiac structure and function, such as fibrosis, several noninvasive techniques have been used. These include echocardiography, cinematic magnetic resonance imaging, and computed tomography. From a mechanistic perspective; oxidative stress, inflammation, enhanced production and deposition of advanced glycation end products (AGEs), mitochondrial dysfunction, impaired mitochondrial Ca2+ handling and function, and endoplasmic reticulum stress are observed. Furthermore activation of the sympathetic nervous system and renin-angiotensin system, microvascular dysfunction, and cardiac metabolic disorders are involved in the pathophysiology of this condition. Numerous proteins and signaling pathways, such as AMPK, FOXO1, SERCA2A, NF-kB, Nrf2, HO-1, MAPK, PKC, and PPARs, may be implicated in the development of diabetic cardiomyopathy. Additionally, increased levels of O-linked N-acetylglucosamine (O-GlcNAc), C-reactive protein, atrial natriuretic peptide, and, brain natriuretic peptide, among others, may also serve as clinical biomarkers to identify diabetic cardiomyopathy. Lifestyle modifications including aerobic exercise, maintaining a healthy weight, and smoking cessation are beneficial treatment measures to avoid diabetic cardiomyopathy. It is significant to note that in people with diabetes mellitus; high blood glucose and systemic and cardiac insulin resistance, are independently correlated to the development and progression of cardiac dysfunction and heart failure. The prevalence of diabetic cardiomyopathy declines with sustained glycemic management. However, a formal definition for diabetic cardiomyopathy as a distinct clinical entity remains poorly defined due to a lack of accepted diagnostic criteria and knowledge of subclinical cardiovascular diseases at the early stages of diabetes mellitus. There is currently no distinct histological features, biochemical markers, or clinical manifestation that can be used to make a definitive diagnosis of diabetic cardiomyopathy. Additionally, there are no prospective clinical trials to back up the claim that high insulin or blood sugar levels alone, without additional risk factors like obesity, coronary heart disease, or high blood pressure, increase the likelihood of developing diabetic cardiomyopathy. To decipher the precise mechanisms behind the onset and progression of diabetic cardiomyopathy, and to develop novel strategies for reducing the risk of heart failure in people with diabetes, further research is necessary. Hence, more clinical observational studies are required to comprehend the unknown factors underlying diabetic cardiomyopathy, and to further investigate novel biomarkers that can be used for risk assessment, screening, and diagnosis. Early detection and early intervention are essential for preventing diabetic cardiomyopathy, which drives ongoing research to better understand and treat this condition.
