This is the second volume of the Patent eBook Series titled Topics in Anti-Cancer Research. The eBook includes updated chapters on topics relevant to contemporary cancer research published in the journal, Recent Patents on Anti-Cancer Drug Discovery. This volume covers scientific and patented novel chemotherapeutic agents and drugs for metastatic castration-resistant prostate cancer and Ras/ Raf /MEK/ERK pathway, P1K, AKT and mTORC1/2 inhibitors, ATPase inhibitors for cancer therapy, and sphingomyelin biosynthesis which regulates cancer cell death and growth. Other chapters also explain research on biochemical regulation i.e. cell cycle and energy metabolism, the role of genetic variations of FcγRs gamma receptors in monoclonal antibody based anti-cancer therapy and effectiveness of antiangiogenic therapy, endogenous angiogenesis inhibitors and anti-angiogenic drugs for the treatment of renal cell carcinoma, prevention of cancer by ribonucleotide reductase, anticancer activity of Erlotinib in glioblastoma and the mechanisms of action of nanodrugs and nano-sized camptothecin drugs in cancer chemotherapy. The volume also covers recent studies in the field of onconutrition. The broad range of topics covered in this second volume will be of immense interest to clinicians, scientists and R&D experts seeking new targets for the prevention of cancer, novel oncogenic biomarkers, and methods for cancer therapy.
This book argues that the history and character of modern anthropology has been egregiously distorted to the detriment of this intellectual pursuit and academic discipline. The "critique of anthropology" is a product of the momentous and tormented events of the 1960s when students and some of their elders cried, "Trust no one over thirty!" The Marxist, postmodern, and postcolonial waves that followed took aim at anthropology and the result has been a serious loss of confidence; both the reputation and the practice of anthropology has suffered greatly. The time has come to move past this damaging discourse. Herbert S. Lewis chronicles these developments, and subjects the "critique" to a long overdue interrogation based on wide-ranging knowledge of the field and its history, as well as the application of common sense. The book questions discourses about anthropology and colonialism, anthropologists and history, the problem of "exoticizing'the Other,'" anthropologists and the Cold War, and more. Written by a master of the profession, In Defense of Anthropology will require consideration by all anthropologists, historians, sociologists of science, and cultural theorists.
Author: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
"Soules's excellent book makes sense of the capitalist forces we all feel but cannot always name... Icebergs, Zombies, and the Ultra Thin arms architects and the general public with an essential understanding of how capitalism makes property. Required reading for those who think tomorrow can be different from today."— Jack Self, coeditor of Real Estates: Life Without Debt In Icebergs, Zombies, and the Ultra Thin, Matthew Soules issues an indictment of how finance capitalism dramatically alters not only architectural forms but also the very nature of our cities and societies. We rarely consider architecture to be an important factor in contemporary economic and political debates, yet sparsely occupied ultra-thin "pencil towers" develop in our cities, functioning as speculative wealth storage for the superrich, and cavernous "iceberg" homes extend architectural assets many stories below street level. Meanwhile, communities around the globe are blighted by zombie and ghost urbanism, marked by unoccupied neighborhoods and abandoned housing developments. Learn how the use of architecture as an investment tool has accelerated in recent years, heightening inequality and contributing to worldwide financial instability: • See how investment imperatives shape what and how we build, changing the very structure of our communities • Delve into high-profile projects, like the luxury apartments of architect Rafael Viñoly's 432 Park Avenue • Understand the convergence of technology, finance, and spirituality, which together are configuring the financialized walls within which we eat, sleep, and work Includes dozens of photos and drawings of architectural phenomena that have changed the way we live. Essential reading for anyone interested in architecture, design, economics, and understanding the way our world is formed.