Zinc Signaling
Zinc Signaling

Author: Toshiyuki Fukada

Publisher: Springer Nature

Published: 2019-12-13

Total Pages: 412

ISBN-13: 9811505578

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This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

Zinc Signals in Cellular Functions and Disorders
Zinc Signals in Cellular Functions and Disorders

Author: Toshiyuki Fukada

Publisher: Springer

Published: 2014-09-25

Total Pages: 345

ISBN-13: 443155114X

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This book describes the crucial role of "zinc signals" in biological processes on a molecular and physiological basis, discussing future directions and questions underlying this unique phenomenon. To accomplish this, a group of worldwide leaders in the field, who have made outstanding contributions, overview zinc signals from a professional standpoint. Zinc plays an indispensable role in various cellular processes. It regulates a great number of protein functions including transcription factors, enzymes, adapters, and growth factors as a structural or catalytic factor or both. Recently, another function of zinc has received extensive interest and attention because of its potential importance as a signaling mediator. Zinc plays a dynamic role as an intracellular and extracellular signaling factor and thus regulates cellular signaling pathways, which enables communication between cells, conversion of extracellular stimuli to intracellular signals, and control of various intracellular events. These functions of zinc have become recognized as “zinc signals,” which play critical roles in physiology, and therefore their imbalance can cause a variety of problems with regard to human health. Because the notion of zinc signals is quite new and no integrative review books focusing on them have yet been published, we believe this book will provide very timely information on the subject and thus should be of importance and interest to a wide range of readers.

Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals
Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals

Author: James F Collins

Publisher: Academic Press

Published: 2016-09-14

Total Pages: 578

ISBN-13: 0128023767

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Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals is a unique reference that provides a complete overview of the non-vitamin micronutrients, including calcium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, and zinc. In addition, the book covers the nutritional and toxicological properties of nonessential minerals chromium, fluoride and boron, and silicon and vanadium, as well as ultra-trace minerals and those with no established dietary requirement for humans. Users will find in-depth chapters on each essential mineral and mineral metabolism, along with discussions of dietary recommendations in the United States and around the world. - Presents the only scientific reference to cover all of the nutritionally relevant essential major and trace minerals - Provides a broad introductory chapter on each mineral to give readers valuable background and context - Clarifies the cellular and molecular aspects of each mineral and its genetic and genomic aspects - Includes coverage of all nutritionally relevant minerals—essential major trace minerals and ultra-trace minerals - Underscores the important interactions between minerals so readers learn how metabolism of one mineral influences another

Protein Nutrition and Mineral Absorption
Protein Nutrition and Mineral Absorption

Author: Raul A. Wapnir

Publisher: CRC Press

Published: 1990-09-25

Total Pages: 360

ISBN-13: 9780849352270

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This volume presents information regarding the mechanisms of protein absorption under normal and pathologic conditions, in addition to reviewing changes that occur at various stages of life. General modifiers of intestinal absorption, such as the processing of foods, the nutritional status of the individual, and disease, are explored with reference to both proteins and minerals. Inorganic macronutrients, namely calcium, magnesium and phosphorus, are discussed in relation to protein ingestion. The book also explores the concept of essential trace elements (e.g., iron, zinc, copper, and iodine) and their link to protein sufficiency. The relationship of ultratrace elements with the content of proteins in food is examined, and the book offers a fresh view of the role of certain elements, particularly zinc, on the conformation of proteins linked to DNA, hormone receptors, and gene products. Protein Nutrition and Mineral Absorption is packed with 2,300 references, 100 figures and graphs, plus 25 tables. Nutritionists and physicians will find this book to be an invaluable reference source for rationalizing nutritional interventions and diet modifications for their patients.

Essential and Toxic Trace Elements and Vitamins in Human Health
Essential and Toxic Trace Elements and Vitamins in Human Health

Author: George J. Brewer

Publisher: Academic Press

Published: 2020-06-14

Total Pages: 328

ISBN-13: 0128093013

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Essential and Toxic Trace Elements and Vitamins in Human Health is a comprehensive guide to the wide variety of micronutrients that affect human health, including fat-soluble and water-soluble vitamins that support diverse biochemical functions, trace elements with established and suggested links to health maintenance, and elements with known human toxicity such as arsenic, cadmium, and lead. An essential reference text for nutritionists working in academia and functional food and supplement industries, dieticians, and clinicians, Essential and Toxic Trace Elements and Vitamins in Human Health provides an in-depth look at toxic trace elements and essential vitamins and minerals and their direct influence on the body's overall health with expert research from renowned scientists. - Presents a balanced scientific view of essential and nonessential micronutrients with an in-depth analysis of the biochemical functions each plays in human health - Examines particular micronutrients in detail with coverage of clinical aspects, interaction with other micronutrients, immunological effects, cognitive functions and epigenetics - Focuses on effective management of micronutrient deficiencies and on toxicity implications of overexposure

Studies of Epithelial Transporters and Ion Channels
Studies of Epithelial Transporters and Ion Channels

Author: Kirk L. Hamilton

Publisher: Springer Nature

Published: 2021-03-04

Total Pages: 1247

ISBN-13: 3030554546

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This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.

Phosphate Metabolism
Phosphate Metabolism

Author: Shaul Massry

Publisher: Springer Science & Business Media

Published: 2013-11-21

Total Pages: 611

ISBN-13: 1461342171

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We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.

Neurodegenerative Diseases
Neurodegenerative Diseases

Author: Uday Kishore

Publisher: BoD – Books on Demand

Published: 2013-05-15

Total Pages: 642

ISBN-13: 9535110888

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This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.