When Blood Breaks Down
When Blood Breaks Down

Author: Mikkael A. Sekeres

Publisher: MIT Press

Published: 2021-08-17

Total Pages: 325

ISBN-13: 0262542250

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A leading cancer specialist tells the powerful stories of 3 adult leukemia patients—shining new light on the hidden history of the disease and the drugs developed to treat it. “A look at leukemia patients’ fear, survival and grace while fighting the disease . . . a quiet chronicle of life with and beyond leukemia, and sometimes life’s end.” —The Washington Post When you are told that you have leukemia, your world stops. Your brain can’t function. You are asked to make decisions about treatment almost immediately, when you are not in your right mind. And yet you pull yourself together and start asking questions. Beside you is your doctor, whose job it is to solve the awful puzzle of bone marrow gone wrong. The two of you are in it together. In When Blood Breaks Down, Mikkael Sekeres, a leading cancer specialist, takes readers on the journey that patient and doctor travel together. Sekeres, who writes regularly for the “Well” section of The New York Times, tells the compelling stories of three people who receive diagnoses of adult leukemia within hours of each other: Joan, a 48-year-old surgical nurse, a caregiver who becomes a patient; David, a 68-year-old former factory worker who bows to his family’s wishes and pursues the most aggressive treatment; and Sarah, a 36-year-old pregnant woman who must decide whether to undergo chemotherapy and put her fetus at risk. We join the intimate conversations between Sekeres and his patients, and we watch as he teaches trainees. Along the way, Sekeres also explores leukemia in its different forms and the development of drugs to treat it—describing, among many other fascinating details, the invention of the bone marrow transplant (first performed experimentally on beagles) and a treatment that targets the genetics of leukemia. The lessons to be learned from leukemia, Sekeres shows, are not merely medical; they teach us about courage and grace and defying the odds.

When Blood Breaks Down
When Blood Breaks Down

Author: Mikkael A. Sekeres

Publisher: MIT Press

Published: 2020-04-21

Total Pages: 325

ISBN-13: 0262043726

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A leading cancer specialist tells the compelling stories of three adult leukemia patients, shedding new light on the disease itself and the drugs developed to treat it When you are told that you have leukemia, your world stops. Your brain can’t function. You are asked to make decisions about treatment almost immediately, when you are not in your right mind. And yet you pull yourself together and start asking questions. Beside you is your doctor, whose job it is to solve the awful puzzle of bone marrow gone wrong. The two of you are in it together. In When Blood Breaks Down, Mikkael Sekeres, a leading cancer specialist, takes readers on the journey that patient and doctor travel together. Sekeres, who writes regularly for the “Well” section of The New York Times, tells the compelling stories of three people who receive diagnoses of adult leukemia within hours of each other: Joan, a 48-year-old surgical nurse, a caregiver who becomes a patient; David, a 68-year-old former factory worker who bows to his family’s wishes and pursues the most aggressive treatment; and Sarah, a 36-year-old pregnant woman who must decide whether to undergo chemotherapy and put her fetus at risk. We join the intimate conversations between Sekeres and his patients, and we watch as he teaches trainees. Along the way, Sekeres also explores leukemia in its different forms and the development of drugs to treat it—describing, among many other fascinating details, the invention of the bone marrow transplant (first performed experimentally on beagles) and a treatment that targets the genetics of leukemia. The lessons to be learned from leukemia, Sekeres shows, are not merely medical; they teach us about courage and grace and defying the odds.

Drugs and the FDA
Drugs and the FDA

Author: Mikkael A. Sekeres

Publisher: MIT Press

Published: 2022-09-27

Total Pages: 319

ISBN-13: 0262047314

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How the FDA was shaped by public health crises and patient advocacy, told against a background of the contentious hearings on the breast cancer drug Avastin. Food and Drug Administration approval for COVID-19 vaccines and the controversial Alzheimer’s drug Aduhelm made headlines, but few of us know much about how the agency does its work. Why is the FDA the ultimate US authority on a drug’s safety and efficacy? In Drugs and the FDA, Mikkael Sekeres—a leading oncologist and former chair of the FDA’s cancer drug advisory committee—tells the story of how the FDA became the most trusted regulatory agency in the world. It took a series of tragedies and health crises, as well as patient advocacy, for the government to take responsibility for ensuring the efficacy and safety of drugs and medical devices. Before the FDA existed, drug makers could hawk any potion, claim treatment of any ailment, and make any promise on a label. But then, throughout the twentieth century, the government was forced to take action when children were poisoned by contaminated diphtheria and smallpox vaccines, an early antibiotic contained antifreeze, a drug prescribed for morning sickness in pregnancy caused babies to be born disfigured, and access to AIDS drugs was limited to a few clinical trials while thousands died. Sekeres describes all these events against the backdrop of the contentious 2011 hearings on the breast cancer drug Avastin, in which he participated as a panel member. The Avastin hearings, he says, put to the test a century of the FDA’s evolution, demonstrating how its system of checks and balances works—or doesn’t work.

Wasted Wombs
Wasted Wombs

Author: Erica van der Sijpt

Publisher: Vanderbilt University Press

Published: 2018-03-27

Total Pages: 324

ISBN-13: 0826504027

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Central to this book are Gbigbil women's experiences with different "reproductive interruptions": miscarriages, stillbirths, child deaths, induced abortions, and infertility. Rather than consider these events as inherently dissimilar as women do in Western countries, the Gbigbil women of eastern Cameroon see them all as instances of "wasted wombs" that leave their reproductive trajectories hanging in the balance. The women must navigate this uncertainty while negotiating their social positions, aspirations for the future, and the current workings of their bodies. Providing an intimate look into these processes, Wasted Wombs shows how Gbigbil women constantly shift their interpretations of when a pregnancy starts, what it contains, and what is lost in case of a reproductive interruption, in contrast to Western conceptions of fertility and loss. Depending on the context and on their life aspirations--be it marriage and motherhood, or an educational trajectory and employment, or profitable sexual affairs with so-called "big fish"--women negotiate and manipulate the meanings and effects of reproductive interruptions. Paradoxically, they often do so while portraying themselves as powerless. Wasted Wombs carefully analyzes such tactics in relation to the various social predicaments that emerge around reproductive interruptions, as well as the capricious workings of women's physical bodies.

Color Theory for the Make-up Artist
Color Theory for the Make-up Artist

Author: Katie Middleton

Publisher: Taylor & Francis

Published: 2022-10-19

Total Pages: 239

ISBN-13: 1000599310

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Color Theory for the Make-up Artist: Understanding Color and Light for Beauty and Special Effects (Second Edition) analyzes and explains traditional color theory for fine artists and applies it to make-up artistry. This beautifully illustrated guide begins with the basics of color theory – why we see color, how to categorize and identify color, and relationships between colors – and relates these concepts to beauty and special effects make-up. The book provides a wealth of information, including how to mix flesh tones by using only primary colors, how these colors in paints and make-up are sourced and created, the reason for variations in skin colors and undertones, and how to identify and match these using make-up while choosing flattering colors for the eyes, lips, and cheeks. Colors found inside the body are explained for special effects make-up, like why we bruise, bleed, or appear sick. Ideas and techniques are also described for painting prosthetics, in addition to using color as inspiration in make-up designs. The book also discusses how lighting affects color on film, television, theater, and photography sets, and how to properly light a workspace for successful applications. The second edition features: A brand-new chapter on color inspiration in make-up and design Additional and updated diagrams More real-life application photos and demonstrations, including new examples of tattoo covering and prosthetic painting using optical mixtures, airbrush, and stippling Expanded discussion on undertones, skin variations, color correction, pigments, colored gels, and more Filled with stunning photography and practical information, Color Theory for the Make-up Artist provides guidance and inspiration for both professionals and beginners who wish to train their eye further to understand and recognize distinctions in color.

Your Skin and Bones
Your Skin and Bones

Author: Melanie Waldron

Publisher: Capstone Classroom

Published: 2014-01-01

Total Pages: 50

ISBN-13: 1410959864

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Examines the human skeleton, muscles, and skin, discussing their composition, structure, functions, and disorders.

Campbell's Physiology Notes For Nurses
Campbell's Physiology Notes For Nurses

Author: John Campbell

Publisher: John Wiley & Sons

Published: 2006-02-22

Total Pages: 208

ISBN-13: 0470032413

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This accessible and friendly text is based on the premise that all nurses need a working knowledge of the normal functioning of the human body. It is only when we understand the normal that the abnormal pathological situation makes sense. If we can understand how the body goes wrong then it often becomes obvious what needs to be done to treat the disorder. So physiology and pathophysiology can both be used to inform our clinical interventions and provide us with rationales for care. In this concise text, John Campbell explains the physiology and necessary basic science in a way that is easy to understand and learn. Diagrams are an important part of this philosophy.