Offering timely coverage of this complex field, Interventional Management of Chronic Visceral Pain Syndromes is a practical, evidence-based guide for the mechanisms, presentation, diagnosis, and treatments of chronic non-malignant and malignant abdominal pain syndromes. Experienced clinicians and academic leaders in pain medicine comprehensively discuss best-practice guidelines using the newest interventional techniques, including dorsal root ganglion stimulation, high frequency spinal cord stimulation, and low-dose intrathecal infusion pumps. Coverage includes malignant and non-malignant gastrointestinal pain, malignant and non-malignant pelvic pain in males and females, rectal pain, and chest pain. - Discusses key demographic characteristics as well as clinical and diagnostic presentations of the most common and esoteric visceral pain syndromes that will enable clinicians to identify pain generators. - Provides a truly systematic approach to the treatment of chronic visceral pain, including the use of pharmacologic, non-interventional, interventional, and multidisciplinary therapies with evidence-based data. - Covers the indications, contraindications, and outcomes results of the newest interventional treatments that all clinicians should be aware of, including neuromodulation and intrathecal pump therapy.
Edited by internationally recognized pain experts, this book offers 73 clinically relevant cases, accompanied by discussion in a question-and-answer format.
about the book... Standing alone as the first definitive and comprehensive book on the subject, this guide describes the most recent studies on the brain-gut connection and psychosocial issues related to patients experiencing visceral pain. Bringing together leading experts from the top-tiers of the science, this source provides 33 engaging chapters and spans basic concepts in pharmacology, neurobiology, physiology, and psychology to provide a practical approach to the treatment of chronic pain. Examining a condition that affects up to 25% of the general U.S. population, this source is the only book on the subject to cover both clinical syndromes and neurobiology...ranges from basic mechanisms to diagnosis and clinical treatment of specific syndromes including inflammatory bowel disease, functional abdominal pain, dyspepsia, non-cardiac chest pain, and pelvic pain syndromes...analyzes the latest scientific advances including the role of functional imaging in patient care...integrates fundamental scientific concepts with a practical clinical approach...and supplies 250 figures, and more than 16 color photographs. about the editors... PANKAJ JAY PASRICHA is Chief, Division of Gastroenterology and Hepatology; Bassel and Frances Blanton Distinguished Professor of Internal Medicine; and Professor of Neuroscience and Cell Biology and Biomedical Engineering; University of Texas Medical Branch (UTMB), Galveston. Dr. Pasricha also heads the Enteric Neuromuscular Disorders and Pain Center at UTMB and has performed pioneering research in pain and motility disorders. Dr. Pasricha has served on numerous national gastroenterological committees and on panels for the National Institutes of Health. He received the M.D. degree (1982) from the All-India Institute of Medical Sciences, New Delhi, India, and post-graduate training in gastroenterology at the Johns Hopkins University Medical School in Baltimore, Maryland. WILLIAM D. WILLIS is Director, Cecil H. and Ida M. Green Chair, and Chief of the Division of Comparative Neurobiology, Marine Biomedical Institute; Professor and Chairman, Department of Anatomy & Neurosciences; and Professor, Department of Physiology & Biophysics; University of Texas Medical Branch, Galveston. Dr. Willis has been President of the Society for Neuroscience (1984-1985), the Association of Neuroscience Departments and Programs (1982-1983), and the American Pain Society (1982-1983). He has also been on the Executive Committee of the American Association of Anatomists (1982-1986) and the Council of the International Association for the Study of Pain (1984-1990). He received the M.D. degree (196) from the University of Texas Southwestern Medical School, Dallas, and the Ph.D. degree (1963) from the Australian National University, Canberra. G. F. GEBHART is Head, Department of Pharmacology, University of Iowa, Iowa City. The author or editor of numerous professional publications, he is editor-in-chief of the Journal of Pain and is the recipient of the Purdue Pharma Prize for Pain Research (2004), as well as the Janssen Award in Gastroenterology for Sustained Achievement (2005). He is a past president of the American Pain Society and President-Elect of the International Association for the Study of Pain. He received the Ph.D. (1971) degree from the University of Iowa, Iowa City.
Covering the newest trends and treatments in pain care, as well as the pain treatment strategies that have been successfully employed in the past, Pain Care Essentials and Innovations brings you fully up to date with effective treatments for acute and chronic pain. It offers expert guidance on both interventional and non-interventional strategies, provided by respected academic physiatrists who practice evidence-based medicine at UCLA and an ACGME-accredited rehabilitation and pain program. - Covers cannabinoids in pain care, novel therapeutics in pain medicine, and integrative care in pain management. - Discusses relevant basic science, psychological aspects of pain care, opioids and practice guidelines, geriatric pain management, and future research in the field. - Consolidates today's available information and guidance into a single, convenient resource.
One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical
The intention of this book is to provide a comprehensive and contemporary review of the biology of sensory nerves. The book is unique, as it comprehensively covers the role of sensory nerves across many therapeutic areas.
Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs. - Compiles all known information on epigenetic regulation of chronic pain in one volume - Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics - Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth - Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain
An expert explores the biological and emotional nature of pain: why it hurts and why some pain is good and some pain is bad. If you touch something hot, it hurts. You snatch your hand away from the hot thing immediately. Obviously. But what is really happening, biologically—and emotionally? In Understanding Pain, Fernando Cervero explores the mechanisms and the meaning of pain. When you touch something hot, your brain triggers a reflex action that causes you to withdraw your hand, protecting you from injury. That kind of pain, Cervero explains, is actually good for us; it acts as an alarm that warns us of danger and keeps us away from harm. But, Cervero tells us, not all pain is good for you. There is another kind of pain that is more like a curse: chronic pain that is not related to injury. This is the kind of pain that fills pain clinics and makes life miserable. Cervero describes current research into the mysteries of chronic pain and efforts to develop more effective treatments. Cervero reminds us that pain is the most common reason for people to seek medical attention, but that it remains a biological enigma. It is protective, but not always. Its effects are not only sensory but also emotional. There is no way to measure it objectively, no test that comes back positive for pain; the only way a medical professional can gauge pain is by listening to the patient's description of it. The idea of pain as a test of character or a punishment to be borne is changing; prevention and treatment of pain are increasingly important to researchers, clinicians, and patients. Cervero's account brings us closer to understanding the meaning of pain.
The Encyclopedia of Pain includes more than 3,000 entries and provides clear, detailed and up-to-date coverage of the current state of research, and treatment of pain. In addition, detailed essays provide in-depth information on all aspects of nociception and pain, including substrates, causes, pathophysiology, symptoms and signs, diagnoses and treatment. A thousand color figures enhance understanding of this too-little-understood topic. The book is available in print, in online only form, or in a print-online bundle.
This book explores the connection of functional pain syndromes (e.g., irritable bowel syndrome and fibromyalgia) with anxiety, depression, chronic fatigue syndrome, and posttraumatic stress disorder. The authors address possible common pathophysiologies and review a range of treatment options, from antidepressants to cognitive-behavioral therapy. Who should buy this book? Whether you are a general practitioner, specialist, or scientist, this book is essential reading. It sheds new light on the complex links between various painful syndromes and disorders.
