The Genetic Landscape of Diabetes
Author: Laura Dean
Publisher:
Published: 2004
Total Pages:
ISBN-13:
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Diabetes Mellitus in Children
Author: Mark A. Sperling
Publisher:
Published: 2005
Total Pages: 0
ISBN-13: 9781416027539
DOWNLOAD EBOOKThe Genetics of Type 2 Diabetes and Related Traits
Author: Jose C. Florez
Publisher: Springer
Published: 2016-04-11
Total Pages: 571
ISBN-13: 3319015745
DOWNLOAD EBOOKThis book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future.
The Genetics of Diabetes Mellitus
Author: W. Creutzfeldt
Publisher: Springer
Published: 1976-05-01
Total Pages: 0
ISBN-13: 9783540076513
DOWNLOAD EBOOKOn February 21 and 22, 1975, an International Workshop on the "Genetics of Diabetes Mellitus" was held in Göttingen, West-Germany. This workshop had been organized hy the Department of Medicine, University of Göttingen, and was generously sponsored by the Deutsche Forschungsgemeinschaft. Some forty geneticists and clinicians from Europe and N orth America, working in the field of diabetes both in man and laboratory animals, participated. The 25lectures presented at the workshop are now assembled for publication. Some of the animated discussion which followed the presentations has been included in the final papers by the speakers. Some lectures summarize the recent literature, others present data from recent research. Thus, a comprehensive and modem review of the theoretical and practical problems of diabetes are offered by this volume. related to the genetics The confusion about the mode of inheritance of diabetes mellitus during the last two decades can only be resolved by joint discussions between geneticists interested in diabetes and clinical diabetologists interested in genetics. Knowledge of modem genetics and of the heterogeneity of diabetes mellitus are necessary in order to disentangle the complex scene. Optimistically, the publication of this work on the genetics of diabetes will help to achieve this aim and to establish the concept of genetic heterogeneity of diabetes mellitus. The editors are grateful to Springer-Verlag, Heidelberg, for the prompt publication of these proceedings and to the Farbwerke Hoechst AG, Frankfurt (M), for their contribution to the printing costs.
Genes and Obesity
Author:
Publisher: Academic Press
Published: 2010-12-17
Total Pages: 417
ISBN-13: 0080962033
DOWNLOAD EBOOKA number of genes have been identified that are associated with an increased body mass index (BMI), the standard measurement of obesity. By analyzing these genes, researchers hope to gain a better understanding of what causes obesity and develop ways to tackle the problem. The study of genes and obesity could lead to new treatments. Genes and Obesity reviews the latest developments in the field. - This series provides a forum for discussion of new discoveries, approaches, and ideas - Contributions from leading scholars and industry experts - Reference guide for researchers involved in molecular biology and related fields
Genetics of Diabetes Mellitus
Author: William L. Lowe
Publisher: Springer Science & Business Media
Published: 2001
Total Pages: 268
ISBN-13: 9780792372523
DOWNLOAD EBOOKGenetics of Diabetes Mellitus is intended to be a resource for both researchers in the field as well as endocrinologists, diabetologists, and geneticists who seek to learn more about this rapidly changing and important field. The text contains chapters from experts in the area who review aspects of the genetics of both type 1 and 2 diabetes mellitus as well as various syndromic forms of diabetes. The chapters are approachable for those who are not experts in the field of genetics but also comprehensive, so as to serve as an important resource for researchers interested in the genetics of diabetes mellitus. A description of basic concepts of the genetics of complex diseases like type 1 and type 2 diabetes is provided as background. Type 1 diabetes is addressed in chapters exploring genetic determinants that affect the autoimmune process characteristic of type 1 diabetes, the role of the insulin gene in the pathogenesis of type 1 diabetes and additional genes that may impact upon the risk of type 1 diabetes. The impact of genetic determinants on the pathophysiology of type 2 diabetes is covered, as are chapters that address specific genes that are important for the development of type 2 diabetes. Finally, syndromic forms of diabetes, including Maturity Onset Diabetes of the Young and mitochondrial diabetes, and the insight that these disorders provide into more common forms of diabetes are reviewed. Thus, this comprehensive and up-to-date text will serve as an important resource for those actively engaged in research in this area and clinicians treating these patients to provide an up-to-date entrée for those seeking to become more knowledgeable in the area.
Changing Numbers, Changing Needs
Author: National Research Council
Publisher: National Academies Press
Published: 1996-10-11
Total Pages: 327
ISBN-13: 0309055482
DOWNLOAD EBOOKThe reported population of American Indians and Alaska Natives has grown rapidly over the past 20 years. These changes raise questions for the Indian Health Service and other agencies responsible for serving the American Indian population. How big is the population? What are its health care and insurance needs? This volume presents an up-to-date summary of what is known about the demography of American Indian and Alaska Native populationâ€"their age and geographic distributions, household structure, employment, and disability and disease patterns. This information is critical for health care planners who must determine the eligible population for Indian health services and the costs of providing them. The volume will also be of interest to researchers and policymakers concerned about the future characteristics and needs of the American Indian population.
Drosophila Models for Human Diseases
Author: Masamitsu Yamaguchi
Publisher: Springer
Published: 2018-06-27
Total Pages: 314
ISBN-13: 9811305293
DOWNLOAD EBOOKMost biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
Understanding Diabetes
Author: R. F. Dods
Publisher: John Wiley & Sons
Published: 2013-02-13
Total Pages: 365
ISBN-13: 1118530624
DOWNLOAD EBOOKA clear explanation of the cause, diagnosis, and treatment of diabetes Written for a broad range of readers, including students, researchers, policymakers, health care providers, and diabetes patients and caregivers, this book explains the underlying biochemistry and physiology of diabetes mellitus. Each chapter contains a glossary that defines key terms, a summary that highlights essential concepts discussed in each section of the chapter, as well as a set of simple problems to help readers gain a richer and deeper understanding of diabetes, from its history to treatment options. Understanding Diabetes begins with an overview of the disease, its worldwide prevalence and cost, and its connection to the global obesity epidemic. The author then explores the history of diabetes, including the first documented description of the disease dating back to 3400 BCE in Ancient Egypt. The next chapter, A Glucose Metabolism Primer, sets forth the pathways for the metabolism of glucose. Next, the book covers: Regulation of glucose metabolism and glucose metabolism gone wrong Diabetes classification system Diagnosis, including current laboratory tests Complications, such as retinopathy, neuropathy, and cardiovascular disease Hereditary transmission Prevention and treatment, including emerging research Although a cure has still not been found, this book demonstrates that researchers are continuing to make major breakthroughs on all fronts in the fight against diabetes, including a better understanding of its causes and an improved ability to diagnose and treat the disease.
International Textbook of Diabetes Mellitus
Author: R. A. DeFronzo
Publisher: John Wiley & Sons
Published: 2015-03-11
Total Pages: 1200
ISBN-13: 1118387678
DOWNLOAD EBOOKThe International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
