Understanding Charged Aerosol Detection with High Performance Liquid Chromatography
Author: Brian John Forsatz
Publisher:
Published: 2007
Total Pages: 160
ISBN-13:
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Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques
Author: Paul H. Gamache
Publisher: John Wiley & Sons
Published: 2017-05-30
Total Pages: 548
ISBN-13: 0470937785
DOWNLOAD EBOOKThe first book devoted exclusively to a highly popular, relatively new detection technique Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques presents a comprehensive review of CAD theory, describes its advantages and limitations, and offers extremely well-informed recommendations for its practical use. Using numerous real-world examples based on contributors’ professional experiences, it provides priceless insights into the actual and potential applications of CAD across a wide range of industries. Charged aerosol detection can be combined with a variety of separation techniques and in numerous configurations. While it has been widely adapted for an array of industrial and research applications with great success, it is still a relatively new technique, and its fundamental performance characteristics are not yet fully understood. This book is intended as a tool for scientists seeking to identify the most effective and efficient uses of charged aerosol detection for a given application. Moving naturally from basic to advanced topics, the author relates fundamental principles, practical uses, and applications across a range of industrial settings, including pharmaceuticals, petrochemicals, biotech, and more. Offers timely, authoritative coverage of the theory, experimental techniques, and end-user applications of charged aerosol detection Includes contributions from experts from various fields of applications who explore CAD’s advantages over traditional HPLC techniques, as well its limitations Provides a current theoretical and practical understanding of CAD, derived from authorities on aerosol technology and separation sciences Features numerous real-world examples that help relate fundamental properties and general operational variables of CAD to its performance in a variety of conditions Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques is a valuable resource for scientists who use chromatographic techniques in academic research and across an array of industrial settings, including the biopharmaceutical, biotechnology, biofuel, chemical, environmental, and food and beverage industries, among others.
Liquid Chromatography
Author: J.G. Shackman
Publisher: Elsevier Inc. Chapters
Published: 2013-01-08
Total Pages: 41
ISBN-13: 0128071400
DOWNLOAD EBOOKThis chapter provides an overview of the most common equipment used for performing high-pressure liquid chromatography (HPLC), under both conventional (up to 6000 psi; 400 bar) and very high pressure conditions (6,000 –20,000 psi; 400-1400 bar), including: pumps, sample injectors, column compartments, and connections. The operation and figures of merit of the most frequently encountered detectors (absorbance, refractive index, nanoparticle based, conductivity, fluorescence, and electrochemical) are also described. Practical tips and considerations for achieving optimal chromatography are provided throughout.
Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques
Author: Paul H. Gamache
Publisher: John Wiley & Sons
Published: 2017-05-08
Total Pages: 540
ISBN-13: 1119390699
DOWNLOAD EBOOKThe first book devoted exclusively to a highly popular, relatively new detection technique Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques presents a comprehensive review of CAD theory, describes its advantages and limitations, and offers extremely well-informed recommendations for its practical use. Using numerous real-world examples based on contributors’ professional experiences, it provides priceless insights into the actual and potential applications of CAD across a wide range of industries. Charged aerosol detection can be combined with a variety of separation techniques and in numerous configurations. While it has been widely adapted for an array of industrial and research applications with great success, it is still a relatively new technique, and its fundamental performance characteristics are not yet fully understood. This book is intended as a tool for scientists seeking to identify the most effective and efficient uses of charged aerosol detection for a given application. Moving naturally from basic to advanced topics, the author relates fundamental principles, practical uses, and applications across a range of industrial settings, including pharmaceuticals, petrochemicals, biotech, and more. Offers timely, authoritative coverage of the theory, experimental techniques, and end-user applications of charged aerosol detection Includes contributions from experts from various fields of applications who explore CAD’s advantages over traditional HPLC techniques, as well its limitations Provides a current theoretical and practical understanding of CAD, derived from authorities on aerosol technology and separation sciences Features numerous real-world examples that help relate fundamental properties and general operational variables of CAD to its performance in a variety of conditions Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques is a valuable resource for scientists who use chromatographic techniques in academic research and across an array of industrial settings, including the biopharmaceutical, biotechnology, biofuel, chemical, environmental, and food and beverage industries, among others.
ISPE Good Practice Guide
Author: Ispe
Publisher:
Published: 2019-01-24
Total Pages: 148
ISBN-13: 9781946964144
DOWNLOAD EBOOKCharacterization of Nanoparticles Intended for Drug Delivery
Author:
Publisher: Springer
Published: 2011-08-14
Total Pages: 284
ISBN-13: 9781607619086
DOWNLOAD EBOOKPharmaceutical Stress Testing
Author: Steven W. Baertschi
Publisher: CRC Press
Published: 2016-04-19
Total Pages: 626
ISBN-13: 1439801800
DOWNLOAD EBOOKThe second edition of Pharmaceutical Stress Testing: Predicting Drug Degradation provides a practical and scientific guide to designing, executing and interpreting stress testing studies for drug substance and drug product. This is the only guide available to tackle this subject in-depth. The Second Edition expands coverage from chemical stability
Analysis of Fatty Acids Using High-performance Liquid Chromatography with Charged Aerosol Detection
Author: Lillian Fua Jaquinod
Publisher:
Published: 2013
Total Pages: 114
ISBN-13:
DOWNLOAD EBOOKA study of parameters (organic content, additives and pH of the mobile phase) to yield good separation and detection of a series of commercially available free fatty acids ranging from C12:0 (lauric acid) to C18:3 (linolenic acid) using HPLC-CAD is undertaken. Working methods using a C18 silica column were assessed by measuring the experimental limit of detection (LOD) and sensitive ranges with consideration to effects of the Charged Aerosol Detector (CAD) temperature and detector voltage. An isocratic method with high content in acetonitrile and low pH was developed that allowed the CAD detection and quantification of the less volatile fatty acids in the range of from around 1 to 5 ng/uL to over 200 ng/uL. A power fit calibration curve was necessitated since the response of the standards did not display a true linear relationship using linear regression analysis. Conditions or mobile phase additives were not found to increase detection of semi-volatile fatty acids such as lauric acid or myristic acid (C14:0). Column bleed was potentially identified as an unexpected additive that resulted in enhanced peak detection, attributed to the formation or stabilization of bigger aerosol particles. The isocratic method was tested for an olive oil standard using an acetonitrile: 0.01M TFA (96.5:3.5) mobile phase, ion voltage at -300 V, and CAD heater setting of 35°C. Using those conditions, separation and detection of major C16 to C18 fatty acids were achieved although palmitic and oleic acids were not completely resolved. The olive oil analysis showed that relative recovery of the major fatty acid components is consistent and supports the use of HPLC-CAD system for a rapid detection of fatty acids at trace levels.
Applications of Ion Chromatography for Pharmaceutical and Biological Products
Author: Lokesh Bhattacharyya
Publisher: John Wiley & Sons
Published: 2012-02-10
Total Pages: 421
ISBN-13: 1118146999
DOWNLOAD EBOOKThis is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals. This book, with contributors from academia, pharma, the biotech industry, and instrument manufacturing, presents the different perspectives, experience, and expertise of the thought leaders of IC in a comprehensive manner. It explores potential IC applications in different aspects of product development and quality control testing. In addition, an appendix section gives information on critical physical and chromatographic parameters related to IC and information on current manufacturers of IC systems, columns, and other components.
Quantitative Chemical Analysis
Author: Daniel C. Harris
Publisher: Macmillan
Published: 2010-04-30
Total Pages: 892
ISBN-13: 1429218150
DOWNLOAD EBOOKQCA is the bestselling textbook of choice for analytical chemistry. It offers a modern portrait of the techniques of chemical analysis, backed by a wealth of real world applications. This edition features new coverage of spectroscopy and statistics, new pedagogy and enhanced lecturer support.
