Photodynamic Therapy with Verteporfin for the Treatment of Neovascular Age-related Macular Degeneration
Photodynamic Therapy with Verteporfin for the Treatment of Neovascular Age-related Macular Degeneration

Author:

Publisher:

Published: 2002

Total Pages: 40

ISBN-13: 9781894620635

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Age-related macular degeneration (AMD) is a disease that causes loss of vision and can lead to central blindness in some patients. Loss of vision from AMD is permanent and has a significant impact on an individual's functioning and quality of life. Currently, there are no effective treatments for the majority of individuals with AMD. Verteporfin photodynamic therapy (PDT) a new treatment for "wet" AMD, the type of AMD responsible for more pronounced vision loss. Evidence from three high-quality RCTs suggests that, compared with placebo, verteporfin PDT treatment for two years reduces the number of cases of central blindness. However, these results apply to a study population with subfoveal neovascularization from AMD, and only a minority of these individuals is likely to qualify for treatment after diagnosis and angiographic assessment. Verteporfin PDT is likely to increase the need for angiographic screening. Treatment is not aimed at restoring vision and the majority of treated individuals will continue to lose visual acuity. Compared to placebo (angiography and sham treatment), verteporfin did not cause an overall increase in serious adverse events and appears to be reasonably well tolerated. The direct impact of this treatment on quality of life and visual function is not known. The two-year incremental costs for this procedure in Canada based on RCT evidence are estimated to be between $10,625 and $14,250.

Focus on Macular Diseases
Focus on Macular Diseases

Author: Sandeep Saxena

Publisher: Jp Medical Limited

Published: 2007

Total Pages: 0

ISBN-13: 9780781791298

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Written by the foremost authorities from around the world, this full-color text describes and thoroughly illustrates state-of-the-art diagnostic and treatment modalities for macular disorders. Coverage begins with contemporary techniques for evaluation of the macula, including optical coherence tomography, microperimetry, and the multifocal electroretinogram. Chapters on outpatient and medical therapies cover laser treatment, intravitreal triamcinolone, and use of photodynamic therapy, transpupillary thermotherapy, anti-vascular endothelial growth factor drugs, and antioxidants for age-related macular degeneration. Internationally acclaimed experts describe surgeries for epiretinal membrane, vitreomacular traction syndrome, idiopathic macular hole, choroidal neovascularization, diabetic macular edema, myopic foveoschisis, and retinal vein occlusion. A DVD accompanying the book contains videos of eleven surgical procedures: epiretinal membrane removal macular hole surgery with trypan blue and indocyanine green staining macular hole surgery with internal limiting membrane removal using triamcinolone surgical removal of choroidal neovascular membrane (submacular surgery) limited macular translocation macular translocation with 360-degree retinotomy surgery for diabetic macular edema surgery for myopic foveoschisis radial optic neurotomy for central retinal vein occlusion arteriovenous sheathotomy for branch retinal vein occlusion 25-gauge transconjunctival standard vitrectomy for macular pucker