Transcription and Translation in Health and Disease
Transcription and Translation in Health and Disease

Author: Manoj Garg

Publisher: Elsevier

Published: 2023-01-30

Total Pages: 418

ISBN-13: 0323995225

DOWNLOAD EBOOK

Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications. It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention. - Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease - Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins - Covers the topic from fundamental knowledge to the latest developments in clinical application - Includes a section dedicated to therapeutic applications

RNA-Based Regulation in Human Health and Disease
RNA-Based Regulation in Human Health and Disease

Author:

Publisher: Academic Press

Published: 2020-08-19

Total Pages: 446

ISBN-13: 0128171944

DOWNLOAD EBOOK

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. - Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease - Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies - Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic - Features contributions from leading experts in the field

Fundamentals of Biochemistry Medical Course and Step 1 Review
Fundamentals of Biochemistry Medical Course and Step 1 Review

Author: David DiTullio

Publisher: McGraw Hill Professional

Published: 2018-11-02

Total Pages: 174

ISBN-13: 1259641902

DOWNLOAD EBOOK

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The biochemistry/USMLE® review you’ve been waiting for . . . clear, concise, high yield, and clinically relevant INCLUDES AN ONLINE VIDEO LECTURE FOR EVERY CHAPTER! The goal of Fundamentals of Biochemistry: Medical Course & Step 1 Review is to make biochemistry an approachable, clinically relevant subject for your first years of medical school, and, most importantly, when you prepare to take the USMLE® Step 1 examination. The authors believe that when biochemistry is put in a clinical context, learning and understanding it becomes much less complicated, as all the pieces of the “puzzle” fall into place. A SELF-CONTAINED, HIGH-YIELD GUIDE UNLIKE ANY OTHER You will find Fundamentals of Biochemistry: Medical Course & Step 1 Review to be a self-contained guide to high-yield biochemistry, with a strong focus on the topics you are most likely to see on the USMLE® Step 1 exam. You can select any chapter and find a self-contained summary of the relevant topic. The authors begin with the basics of the cell and DNA, and protein synthesis, then cover the central aspects of metabolism, and finish with nutrition and genetics. EASY-TO-ABSORB CHAPTERS ENHANCED BY COMPANION ONLINE VIDEOS The information is delivered in a simple outline format that pinpoints the high-yield information you need to know. Each chapter is also presented as a lecture, in video format, so you can review the topic in real time and add additional notes as you learn each topic or review them later.

Translational Systems Medicine and Oral Disease
Translational Systems Medicine and Oral Disease

Author: Stephen T. Sonis

Publisher: Academic Press

Published: 2019-09-14

Total Pages: 460

ISBN-13: 0128137630

DOWNLOAD EBOOK

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. - Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine - Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases - Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader - Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

The Human Body in Health & Disease - E-Book
The Human Body in Health & Disease - E-Book

Author: Kevin T. Patton

Publisher: Elsevier Health Sciences

Published: 2017-01-11

Total Pages: 850

ISBN-13: 0323402062

DOWNLOAD EBOOK

No one explains A&P more clearly! The Human Body in Health & Disease, 7th Edition makes it easier to understand how the body works, both in normal conditions and when things go wrong. Its easy-to-read writing style, more than 500 full-color illustrations, and unique Clear View of the Human Body transparencies keep you focused on the principles of anatomy, physiology, and pathology. New to this edition are Connect It! features with bonus online content and concept maps with flow charts to simplify complex topics. From noted educators Kevin Patton and Gary Thibodeau, this book presents A&P in a way that lets you know and understand what is important. - More than 545 full-color photographs and drawings bring difficult A&P concepts to life and illustrate the most current scientific knowledge. - Clear, conversational writing style breaks down information into brief 'chunks,' making principles easier to understand. - UNIQUE! Clear View of the Human Body transparencies allow you to peel back the layers of the body, with a 22-page, full-color insert showing the male and female human body along several planes. - Over 50 Animation Direct 3-D animations provide dynamic visual explanations for key concepts, with callouts in the text directing you to these animations on the Evolve companion website. - Language of Science/Language of Medicine presents lists of medical terms, pronunciations, and word parts to help you become familiar with A&P terminology and the meanings of individual word parts. - Useful learning features include study tips, chapter objectives, case studies, critical thinking questions, summary boxes, review questions, and chapter tests. - A study guide reinforces your understanding of anatomy and physiology with a variety of practical exercises to help you review and apply key A&P concepts. Sold separately. - NEW and UNIQUE! Connect It! articles on the Evolve companion website provide bonus information for you to explore, and are called out in the text. - NEW and UNIQUE! Active Concept Maps on Evolve utilize animated and narrated flow charts to explain complex topics, and are also called out in the text. - NEW! Chapter objectives and Active Learning sections more closely tie objectives to the end-of-chapter material. - UPDATED! Genetics chapter includes the latest and most important advances.

DNA Methylation and Complex Human Disease
DNA Methylation and Complex Human Disease

Author: Michel Neidhart

Publisher: Academic Press

Published: 2015-08-11

Total Pages: 546

ISBN-13: 0127999205

DOWNLOAD EBOOK

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. - Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity - Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field - Describes wholly new concepts, including the linking of metabolic pathways with epigenetics - Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

Mitochondria in Health and Disease
Mitochondria in Health and Disease

Author: Carolyn D. Berdanier

Publisher: CRC Press

Published: 2005-06-09

Total Pages: 640

ISBN-13: 1420028847

DOWNLOAD EBOOK

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses f

Beyond the Molecular Frontier
Beyond the Molecular Frontier

Author: National Research Council

Publisher: National Academies Press

Published: 2003-03-19

Total Pages: 238

ISBN-13: 0309168392

DOWNLOAD EBOOK

Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.

Clinical Mitochondrial Medicine
Clinical Mitochondrial Medicine

Author: Patrick F. Chinnery

Publisher: Cambridge University Press

Published: 2018-05-17

Total Pages: 229

ISBN-13: 0521132983

DOWNLOAD EBOOK

This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.