Traditional Chinese Medicine (TCM): A multi target approach to complex cardiovascular disease - Volume I
Author: Jing-Yan Han
Publisher: Frontiers Media SA
Published: 2021-07-29
Total Pages: 346
ISBN-13: 288971117X
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Traditional Chinese Medicine: Organ Vascular Injury - Volume II
Author: Jing-Yan Han
Publisher: Frontiers Media SA
Published: 2024-07-25
Total Pages: 346
ISBN-13: 2832552056
DOWNLOAD EBOOKOrgan vascular injury is the basis of multiple organ damage. which is a complex pathological process with multiple mechanisms and links among mechanisms contributing to the disease. To cope much management often focuses a single drug on a single target which is frequently not entirely effective. Chinese medicine with a long traditional history extending more than 2000 years is a medical system that applies multiple ingredients associated with the resolution of complex disease problems. Numerous compounded Chinese medicines have shown very desirable effects on organ vascular injury related disease in clinical use. For example, a number of studies over the past decades has revealed a positive protective and therapeutic effect of compounded Chinese medicines and their major ingredients on Ischemia reperfusion-induced microcirculatory dysfunction and tissue injury in the heart, brain, liver, intestine, and lungs. These compounded medications contain diverse bioactive components with demonstrated ability to target energy metabolism; possess antioxidant effects; inhibit inflammatory cytokine release; alter adhesion molecule expression in leukocytes, platelets, and vascular endothelial cells; and the protect against thrombosis, albumin leakage, and mast cell degranulation.
Handbook Of Traditional Chinese Medicine (In 3 Volumes)
Author: Stevenson Xutian
Publisher: World Scientific
Published: 2014-09-19
Total Pages: 1491
ISBN-13: 9814571342
DOWNLOAD EBOOKFor over two thousand years, Traditional Chinese Medicine (TCM) has made many significant contributions to China's growth and prosperity. This textbook, based on the unique characteristics of TCM, discusses its principle theories and presents a comprehensive daily practice guide for health maintenance and disease treatment. The book provides clinical practitioners with a fundamental understanding of the essence of TCM.We highly recommend this book for students interested in TCM, Chinese medicine doctors and other healthcare professionals, biomedical researchers, and interested individuals. Readers will benefit from the inspirational viewpoints discussed in the book.
Drug Discovery and Evaluation: Methods in Clinical Pharmacology
Author: H.Gerhard Vogel
Publisher: Springer Science & Business Media
Published: 2010-12-15
Total Pages: 576
ISBN-13: 3540898905
DOWNLOAD EBOOKDrug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
Chinmedomics
Author: Xijun Wang
Publisher: Academic Press
Published: 2015-07-15
Total Pages: 408
ISBN-13: 0128031182
DOWNLOAD EBOOKChinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. - Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method - Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications - Edited by the leading experts of research related to Chinmedomics
Serum Pharmacochemistry of Traditional Chinese Medicine
Author: Xijun Wang
Publisher: Academic Press
Published: 2016-12-27
Total Pages: 380
ISBN-13: 0128111488
DOWNLOAD EBOOKSerum Pharmacochemistry of Traditional Chinese Medicine: Technologies, Strategies and Applications provides a valuable and indispensable guide on the latest methods, research advances, and applications in this area. Chapters offer cutting-edge information on pharmacokinetics and pharmacodynamics, analytical chemistry, traditional medicine, natural products, bioinformatics, new technologies, therapeutic applications, and more. For researchers and students in academia and industry, this book provides a hands-on description of experimental techniques, along with beneficial guidelines to help advance research in the fields of Traditional Chinese Medicine and drug development. - Provides a valuable guide for practitioners of serum pharmacochemistry of Traditional Chinese Medicine, along with insights to its current use and future applications - Edited and written by leading scientists at the forefront of this research - Presents well written chapters that include an introduction, description of the method, and identification of chemical constituents, with applications and references to the latest research and literature
Brain Drug Targeting
Author: William M. Pardridge
Publisher: Cambridge University Press
Published: 2001-05-31
Total Pages: 377
ISBN-13: 0521800773
DOWNLOAD EBOOKThis challenging 2001 book reviews modern neurotherapeutics from the point of view of drug targeting.
Network Pharmacology
Author: Shao Li
Publisher: Springer Nature
Published: 2021-09-29
Total Pages: 480
ISBN-13: 9811607532
DOWNLOAD EBOOKThis book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
Cancer Cell Metabolism and Drug Targets
Author: Hai-long Piao
Publisher: Frontiers Media SA
Published: 2023-11-22
Total Pages: 168
ISBN-13: 2832539289
DOWNLOAD EBOOKTargeted cancer metabolic pathway anti-cancer drugs achieved great success in malignant cancer treatment, however, inevitably the effect of almost all these drugs is compromised by the development of resistance. Given that recent evidence shows cancer cell metabolic reprogramming occurs after drug treatment, probably, there is a strong relationship between a specific target and particular metabolic pathway remodeling. Understanding the hidden fact and mechanisms under cell metabolism modulated by specific drug targets (in particular those related to precision medicine) may lead to the development of new therapeutic strategies to overcome drug resistance.
Pharmacological Effects of Traditional Chinese Medicine on Cardiovascular Disease
Author: Jianxun Liu
Publisher: Frontiers Media SA
Published: 2021-12-03
Total Pages: 227
ISBN-13: 2889717984
DOWNLOAD EBOOKCardiovascular diseases include ischemic and hemorrhagic diseases involving the heart, brain, whole body tissue, and includes coronary heart disease, heart failure, arrhythmia, atherosclerosis and stroke. This particular group of diseases continue to be a leading cause of death throughout the world with mortality rate remaining high. Currently, drugs administered orally and intravenously and surgical treatments are used to treat such diseases. Traditional Chinese medicine (TCM) refers to natural herbal medicines and their processed products used for preventing and treating disease under the guidance of traditional Chinese medicine’s theory. The implementation of prevention and treatment programs of ischemic cardiovascular diseases with the use of TCM have been associated with positive outcomes; in terms of a reduction in the disability and mortality rate of some patients. Other studies have also shown that specific multi-component TCM preparations have therapeutic benefits based on multi-target and multi-pathway mechanisms, which may have advantages over the current single-component and single-target therapy. Based these characteristics, approved pharmaceutical drugs based in TCM, such as Compound Danshen Dripping Pills, Naoxintong Capsules, Tonxinluo Capsules, and Danhong Injection, are currently used to treat cardiovascular diseases. However, there are a number of areas that still need further investigation. For example, the identification of effective components in herbal medicine is essential in furthering our understanding of what occurs at a pharmacological level; the metabolizing pharmacological pathways of such components; the cellular target of the components; and the lack of standardized guidelines to enhance clinical research.
