This new Springer volume, which comes complete with a free DVD, is a comprehensive and detailed overview of the synapse with emphasis on the glutamatergic synapse. Most chapters relate the synapse’s functional aspects to its molecular mechanisms. This approach shows which mechanisms are characterized on both the functional and structural level and can thus be considered firmly established. It’s an important text for neuroscientists and disease-oriented clinicians in neurology.
"For both seasoned neurobiologists and interested newcomers to the field, this book is a worthwhile introduction to the wonders of synapses and the many opportunities for future study that they offer." -- "Science"
The Physiology of Synapses covers the considerable advances in understanding the complex physiology of synapses. This book is divided into 16 chapters that emphasize the mechanism of synaptic transmission. The first chapters describe the structural and physiological features of chemically transmitting synapses. The subsequent chapters deal with the excitatory postsynaptic responses to presynaptic impulse and the release of transmitter by presynaptic impulses. These topics are followed by discussions of the impulse generation by the excitatory postsynaptic potential; the postsynaptic electrical events produced by chemically transmitting inhibitory synapses; the ionic mechanism generating the inhibitory postsynaptic potential. The last chapters consider the mechanism of inhibitory transmitter substances, pathways responsible for postsynaptic inhibitory action, and the trophic and plastic properties of synapses. This book will prove useful to physiologists, neurologists, and researchers.
The History of the Synapse provides a history of those discoveries concerning the identification and function of synapses that provide the foundations for research during this new century with a personal view of the process by which new concepts have developed. Previously published as essays, the chapters in this book provide a history of various aspects of synaptic function, beginning with the evolution over two and a half thousand years and how progress was made in the establishment of a conceptual structure that would allow the synapse to be identified at the beginning of the 20th century. Numerous illustrations explain either the technical approach or the experimental finding.
The new thrilling sci-fi novel from the author of New Pompeii and Empire of Time In a future London, humans are watched over by AIs and served by bots. But now that justice and jobs are meted out by algorithm, inequality blooms, and protest is brutally silenced. Anna Glover may be the most hated woman in the troubled city - the media's scapegoat for an unpopular war. Now she hides from the public eye, investigating neglected cases by using the mind-invading technology of the synapse sequencer to enter witnesses' memories. When a PI brings her a new high-stakes case, Anna sees a chance for atonement. But soon she is drawn into a plot that threatens to upend her hard-won anonymity and put everyone in danger - even those she hopes to save.
This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.
Two Doctors, the Spaniard Cajal and the Italian Golgi, were racing against each other to find out what brain cells looked like and how they managed to communicate with one another.
Thirty years in the future, when AI is so advanced that humans live side by side with cognizant humanoid robots called Artificials, Kestrel Hathaway must come to terms not just with what machines?know,?but with what they?believe. Soon after experiencing a personal tragedy, Kestrel witnesses a terrorist attack on a nearby artificial factory and is drawn into a world of conspiracies and lies that she and Jordan, her Artificial, have to untangle. With a second, more brutal attack looming on the horizon, their best chance of stopping it is teaming up with federal counterterrorism agent Nick Vernon. But the clock is ticking—and all the while, Jordan is asking questions Artificials were never meant to ask. Deftly weaving suspense and intrigue into a rich, resonant tale that explores faith and what it really means to be human, Steven James offers us a glimpse into the future—and into our own hearts. Synapse?is an unforgettable, gripping story of dreams shattered, truth revealed, and hope reborn. Praise for?Synapse: “Perfectly timed and thought-provoking,?Synapse?is a smart, intense thriller that keeps the suspense?building until the final page. Steven James once again delivers a perfect amalgam of character and?plot, totally immersing the reader in an irresistible narrative.” —Simon Gervais, international bestselling author of?Hunt Them Down “Next-level suspense that keeps the pages turning, combined with next-level writing on par?with the great literary masters . . .?Synapse?is not merely a thriller you should read—as 5G?approaches and advances in AI snowball, it is the thriller you can’t afford?not to.” —James R. Hannibal, award-winning author of?The Gryphon Heist
Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders. Provides a comprehensive reference on synaptic structure, physiology, function and neurotransmission Discusses many landmark experiments in the field of synaptic transmission to emphasize core principles Includes references to primary scientific literature, relevant review articles and books, many of which could be assigned as discussion material for courses focused on this topic
