The Macrophage in Neoplasia
The Macrophage in Neoplasia

Author: Marine Biological Laboratory (Woods Hole, Mass.)

Publisher:

Published: 1976

Total Pages: 288

ISBN-13:

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Session I. Role of tumor macrophages in Vivo / William Regelson -- Session II. Macrophage function and interaction / Dolph O. Adams -- Session III. Mechanisms of macrophage mediated cytotoxicity / D. Bernard Amos -- The macrophage as a tumoricidal effector cell: a review in Vivo and In Vitro, Studies on the mechanism of the activated macrophage nonspecific cytotoxic reaction / John B. Hibbs, Jr. -- Morphologic aspects of tumor cell cytotoxicity by effector cells of the macrophage-histocyte compartment: in Vitro and in Vivo studies in BCG-mediated tumor regression / M.G. Hanna [and others] -- Session IV. Functional expression of macrophages and neoplasia / Osias Stutman -- The employment of Glucan and glucan activated macrophages in the enhancement of host resistance to malignancies in experimental animals / N.R. DiLuzio [and others] -- Session V. Stimulation of macrophage function and applied therapy / Ole A. Holtermann -- The in Vivo destruction of human tumor by glucan activated macr ...

Macrophages & Cancer
Macrophages & Cancer

Author: Gloria H. Heppner

Publisher: CRC Press

Published: 2019-06-04

Total Pages: 229

ISBN-13: 1000006158

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First Published in 1988, this book offers a full, comprehensive guide into the relationship between macrophages and Cancer. Carefully compiled and filled with a vast repertoire of notes and references this book serves as a useful reference for Students of Medicine, Oncology and other practitioners in their respective fields.

Regional Chemotherapy
Regional Chemotherapy

Author: Maurie Markman

Publisher: Springer Science & Business Media

Published: 2000-01-02

Total Pages: 363

ISBN-13: 1592592198

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Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antineoplastic drug delivery in the management of malignant disease. These authorities present a critical analysis of both the rationale and limitations of regional therapy and discuss potential clinical trials designed to explain the effectiveness of this method of therapy in special settings. Their presentations describe many exciting and innovative strategies for using regional drug delivery in anticancer therapy, including coverage of such areas of special interest as colorectal, skin, lung, pancreatic, ovarian, and gastrointestinal cancers. Comprehensive and authoritative, Regional Chemotherapy: Clinical Research and Practice offers surgical and medical oncologists and clinical cancer investigators a gold-standard review of the current role and future development of this increasingly powerful weapon in the battle against cancer.

Inflammation and Cancer
Inflammation and Cancer

Author: Bharat B. Aggarwal

Publisher: Springer

Published: 2014-05-12

Total Pages: 489

ISBN-13: 3034808372

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This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

The Macrophage In Neoplasia
The Macrophage In Neoplasia

Author: Mary Fink

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 276

ISBN-13: 0323158153

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The Macrophage in Neoplasia is a compilation of papers presented at a workshop held at the Marine Biological Laboratory, Woods Hole, Massachusetts, on October 8-11, 1975. The book presents the many faceted activities of macrophage. This book is divided according to the five sessions of the workshop. First session talks about the role of tumor macrophages in vivo. It then elucidates the macrophage function and indicates how the interaction of macrophages with other cells can alter the host-tumor balance. The remaining sessions, as presented in this book, explore the mechanism of macrophage mediated cytotoxicity, functional expression of macrophages and neoplasia, and the stimulation of macrophage function and applied therapy.

Chemokines and Cancer
Chemokines and Cancer

Author: Barrett Rollins

Publisher: Springer Science & Business Media

Published: 1999

Total Pages: 346

ISBN-13:

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Since the introduction of microscopy, pathologists have noted tumor infiltration by inflammatory cells and presumed that this represents the host's attempt to reject its tumor. Recent advances in the molecular biology of inflammation have revealed the signals involved in attracting inflammatory cells to tumors and, for the most part, these signals are mediated by chemokines and their receptors. Chemokines are low molecular weight proteins that attract and activate specific subsets of leukocytes to the exclusion of others.

Approaching Complex Diseases
Approaching Complex Diseases

Author: Mariano Bizzarri

Publisher: Springer Nature

Published: 2020-04-17

Total Pages: 493

ISBN-13: 3030328570

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This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

Translocator Protein (TSPO)
Translocator Protein (TSPO)

Author: Giovanni Natile

Publisher: MDPI

Published: 2018-03-05

Total Pages: 177

ISBN-13: 3038427578

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This book is a printed edition of the Special Issue "Translocator Protein (TSPO)" that was published in IJMS

Tumor Immunology and Immunotherapy
Tumor Immunology and Immunotherapy

Author: Robert C. Rees

Publisher: Oxford University Press, USA

Published: 2014

Total Pages: 469

ISBN-13: 0199676860

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Tumor immunology and immunotherapy provides a comprehensive account of cancer immunity and immunotherapy. Examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines, this book provides insight into how these problems may be overcome as viewed by leaders in the field.