Sunao Tawara's epoch-making work on the excitation conduction system of the mammalian heart paved the way for the advancement of modern cardiology in the 20th century. Even today, more than 90 years after the publication of the German monograph “Das Reizleitungssystem des Säugetierherzen”, his precise account of the conduction system from the atrioventricular node through the His-Purkinje system to the ordinary ventricular muscle fibers retains all of its original actuality.This English edition of Tawara's monograph will serve as an invaluable reference for both basic and clinical cardiological research in the years ahead.
Ultrastructure in Biological Systems, Volume 6: Ultrastructure of the Mammalian Heart focuses on the mammalian heart with some cross-reference to that of other vertebrates, such as birds. This book is divided into four main topics— ultrastructure of ventricular and atrial myocardium; impulse generation and conduction system of the heart; embryologic development of the mammalian heart; and ultrastructure of the innervation of the mammalian heart. In these topics, this publication specifically discusses the sarcotubular system (SR), contractile apparatus, general description of cellular morphology, and physiologic implications of cellular and fiber structure. The origin and cytodifferentiation of heart muscle cells, innervation of the sino-atrial node, and ultrastructure of the sympathetic cervical ganglion are also deliberated. This volume is a good source for biologists and students researching on the ultrastructure of the mammalian heart.
The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues. The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood. This book draws together contributions from an international and interdisciplinary group of experts working on both basic and clinical aspects of cardiac development. It features reviews of the structure and function of the developing PCS, discussion of the molecular and cellular mechanisms regulating embryological development of this system and studies on the fundamental basis of PCS pathology. The book also considers how novel therapeutic interventions based on understanding of the developmental biology of cardiac pacemaking and conduction tissues might ultimately impact on clinical medicine.
Guide to Canine and Feline Electrocardiography offers a comprehensive and readable guide to the diagnosis and treatment of abnormal heart rhythms in cats and dogs. Covers all aspects of electrocardiography, from basics to advanced concepts of interest to specialists Explains how to obtain high-quality electrocardiograms Offers expert insight and guidance on the diagnosis and treatment of simple and complex arrhythmias alike Features numerous case examples, with electrocardiograms and Holter monitor recordings Shows the characteristics of normal and abnormal heart rhythms in dogs and cats Includes access to a website with self-assessment questions and the appendices and figures from the book
This book covers the latest information on the anatomic features, underlying physiologic mechanisms, and treatments for diseases of the heart. Key chapters address animal models for cardiac research, cardiac mapping systems, heart-valve disease and genomics-based tools and technology. Once again, a companion of supplementary videos offer unique insights into the working heart that enhance the understanding of key points within the text. Comprehensive and state-of-the art, the Handbook of Cardiac Anatomy, Physiology and Devices, Third Edition provides clinicians and biomedical engineers alike with the authoritative information and background they need to work on and implement tomorrow’s generation of life-saving cardiac devices.
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
This book provides clinical and electrovectorcardiographic evidence of the existence of left septal fascicular blocks and demonstrates the clinical importance of these blocks in the clinical scenario of acute coronary syndrome. There are currently no standard criteria for detecting conduction defects involving the third left fascicle, the septal or median fascicle, and the very existence of such defects is still a matter of controversy. This book provides acceptable and consistent terminology and definitions for the electrovectorcardiographic diagnosis of a left septal fascicular block. Left Septal Fascicular Block: Characterization, Differential Diagnosis and Clinical Significance is an original and unique book that sheds light on an important topic of discussion in cardiac electrophysiology.
A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.
Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. - Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research - Gives concise explanations of key issues and background reading suggestions - Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
An understanding of the structure and function of the human body is vital for anyone studying the medical and health sciences. In this book, Leslie Klenerman provides a clear and accessible overview of the main systems of the human anatomy, illustrated with a number of clear explanatory diagrams.
