Molecular Biology of The Cell
Author: Bruce Alberts
Publisher:
Published: 2002
Total Pages: 0
ISBN-13: 9780815332183
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Chromosomes
Author: Adrian T. Sumner
Publisher: John Wiley & Sons
Published: 2008-04-30
Total Pages: 304
ISBN-13: 0470695226
DOWNLOAD EBOOKIntegrating classical knowledge of chromosome organisation with recent molecular and functional findings, this book presents an up-to-date view of chromosome organisation and function for advanced undergraduate students studying genetics. The organisation and behaviour of chromosomes is central to genetics and the equal segregation of genes and chromosomes into daughter cells at cell division is vital. This text aims to provide a clear and straightforward explanation of these complex processes. Following a brief historical introduction, the text covers the topics of cell cycle dynamics and DNA replication; mitosis and meiosis; the organisation of DNA into chromatin; the arrangement of chromosomes in interphase; euchromatin and heterochromatin; nucleolus organisers; centromeres and telomeres; lampbrush and polytene chromosomes; chromosomes and evolution; chromosomes and disease, and artificial chromosomes. Topics are illustrated with examples from a wide variety of organisms, including fungi, plants, invertebrates and vertebrates. This book will be valuable resource for plant, animal and human geneticists and cell biologists. Originally a zoologist, Adrian Sumner has spent over 25 years studying human and other mammalian chromosomes with the Medical Research Council (UK). One of the pioneers of chromosome banding, he has used electron microscopy and immunofluorescence to study chromosome organisation and function, and latterly has studied factors involved in chromosome separation at mitosis. Adrian is an Associate Editor of the journal Chromosome Research, acts as a consultant biologist and is also Chair of the Committee of the International Chromosome Conferences. The most up-to-date overview of chromosomes in all their forms. Introduces cutting-edge topics such as artificial chromosomes and studies of telomere biology. Describes the methods used to study chromosomes. The perfect complement to Turner.
Chromosome Biology
Author: Rudi Appels
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 405
ISBN-13: 1461554098
DOWNLOAD EBOOKChromosome biology has been brought to a golden age by phenomenal advanced in molecular genetics and techniques. This is true in the plant arena, and it is becoming increasingly true in animal studies, where chromosomes are more difficult to work with. With advanced knowledge of transformation, scientists can tell exactly where a new element enters a chromosome. Conversely, molecular biologists can make large mistakes if they do not understand the behavior of chromosomes. Written by internationally recognized experts in the field, this book is the most authoritative work on the subject to date. Students of genetics, crop science and plant breeding, entomology, animal science, and related fields will benefit from this comprehensive and practical textbook.
The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment
Author: Jessica Wapner
Publisher: The Experiment, LLC
Published: 2014-04-08
Total Pages: 345
ISBN-13: 1615191658
DOWNLOAD EBOOKOne of The Wall Street Journal’s 10 Best Nonfiction Books of the Year Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.
Human Chromosomes
Author: Orlando J. Miller
Publisher: Springer Science & Business Media
Published: 2011-06-28
Total Pages: 508
ISBN-13: 1461301394
DOWNLOAD EBOOKThe fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. This new edition continues to cover both basic and up-to-date material on normal and defective chromosomes, yet is particularly strengthened by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects. The mapping and molecular analysis of chromosomes is one of the most exciting and active areas of modern biomedical research, and this book will be invaluable to scientists, students, technicians and physicians with an interest in the function and dysfunction of chromosomes.
Some Aspects of Chromosome Structure and Function
Author: R.C. Sobti
Publisher: Springer Science & Business Media
Published: 2002-07-31
Total Pages: 266
ISBN-13: 9780792370574
DOWNLOAD EBOOKThis volume is a compilation of twenty articles written by scientists from different parts of the world dealing with various aspects of repetitive sequences in chromosomes, telomeric sequences and their maintenance by telomerase, chromatin structure and gene activation, centrometric complexity in holocentric chromosomes, translocation frequencies in X and Y chromosomes and evolution of DNA repair mechanisms, cytogenetics of certain groups of animals viz. lepidoptera, fishes and birds, and radiosensitivity as an indicator of predisposition to breast cancer. The molecular genetics of various cancers viz., gastrointestinal, lung, prostate, and bladder is also discussed.
Mapping and Sequencing the Human Genome
Author: National Research Council
Publisher: National Academies Press
Published: 1988-01-01
Total Pages: 128
ISBN-13: 0309038405
DOWNLOAD EBOOKThere is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Chromosome 6
Author: Robin Cook
Publisher: Penguin
Published: 1998-04-01
Total Pages: 484
ISBN-13: 9780425161241
DOWNLOAD EBOOK“Master of the medical thriller.”—The New York Times In his most prophetic thriller yet, Robin Cook goes behind the headlines on cloning and genetic manipulation, blending fact with fiction in this terrifying bestseller. In the jungles of equatorial Africa, a biotechnology giant has taken transplant surgery and animal research to a new level—where one mistake could bridge the evolutionary gap between man and ape and forever change the genetic map of our existence. Meanwhile, in New York City, Jack Stapleton and Laurie Montgomery are working on a seemingly unrelated murder of a mobster, only to find some very odd things once their victim is on the autopsy table...
Chromosome Abnormalities and Genetic Counseling
Author: R.J. MKinlay Gardner
Publisher: OUP USA
Published: 2012
Total Pages: 650
ISBN-13: 0195375335
DOWNLOAD EBOOKAdvances in cytogenetics continue to crop up in wonderful ways, and we know exponentially more about chromosomes now than mere decades ago. Likewise, the necessary skills in offering genetic counseling continue to evolve. This new edition of Chromosome Abnormalities in Genetic Counseling offers a practical, up-to-date guide for the genetic counselor to marshal cytogenetic data and analysis clearly and effectively to families.
Genome
Author: Matt Ridley
Publisher: Harper Collins
Published: 2013-03-26
Total Pages: 370
ISBN-13: 0062253468
DOWNLOAD EBOOK“Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability.” — The New Yorker The genome's been mapped. But what does it mean? Matt Ridley’s Genome is the book that explains it all: what it is, how it works, and what it portends for the future Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.
