The Cerebellum: From Embryology to Diagnostic Investigations
The Cerebellum: From Embryology to Diagnostic Investigations

Author:

Publisher: Elsevier

Published: 2018-06-08

Total Pages: 366

ISBN-13: 0444639578

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The Cerebellum: From Embryology to Diagnostic Investigations, Volume 154 is designed to update the reader on the latest and clinically relevant advances in the study of cerebellar diseases in children and adults. It is organized into sections detailing: (1) Embryology, Anatomy and Function, and (2) Diagnostic investigations: Neuroimaging, and includes content on conventional sequences, diffusion tensor imaging, functional MRI, and connectivity studies. Its companion volume, The Cerebellum: Disorders and Treatment, describes disorders (starting from the fetal cerebellum, to adult cerebellum) encountered during daily practice and therapy (including insights into innovative drug and rehabilitative approaches to treat children and adults with cerebellar disorders). Provides an in-depth understanding of the cerebellum and its involvement in a wide variety of diseases Explores the long-term outcome data of pediatric cerebellar diseases and potential problems in adult life for patients with pediatric cerebellar diseases Features chapters co-authored by two experts, combining expertise in both pediatric and adult cerebellar diseases

The Cerebellum: Disorders and Treatment
The Cerebellum: Disorders and Treatment

Author:

Publisher: Elsevier

Published: 2018-06-08

Total Pages: 442

ISBN-13: 0444641904

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The Cerebellum: Disorders and Treatment, Volume 155 updates readers on the latest and clinically relevant advances in the study of cerebellar diseases in children and adults. It is organized into sections detailing: (1) Disorders (starting from the fetal cerebellum, to adult cerebellum) encountered during daily practice, and (2) Therapy (including insights into innovative drug and rehabilitative approaches). The book's innovative structure discusses cerebellar disorders in children and adults as a continuum, with its companion volume, The Cerebellum: From Embryology to Diagnostic Investigations detailing embryology, anatomy, function and diagnostic investigations and neuroimaging, including conventional sequences, diffusion tensor imaging, functional MRI, and connectivity studies. Provides an in-depth understanding of the cerebellum and its involvement in a wide variety of diseases Explores long-term outcome data of pediatric cerebellar diseases and potential problems in adult life for patients with pediatric cerebellar diseases Features chapters co-authored by two experts, combining expertise in both pediatric and adult cerebellar diseases

Development of the Cerebellum from Molecular Aspects to Diseases
Development of the Cerebellum from Molecular Aspects to Diseases

Author: Hassan Marzban

Publisher: Springer

Published: 2017-07-27

Total Pages: 502

ISBN-13: 3319597493

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The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.

Cerebellar Disorders
Cerebellar Disorders

Author: Mario Ubaldo Manto

Publisher: Cambridge University Press

Published: 2010-03-25

Total Pages: 313

ISBN-13: 1139487264

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During the last three decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and the biology of mental processes, behavioral symptoms and emotion. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias, and the growing number of diseases presents a source of difficulty for clinicians during daily practice. This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice. Essential reading for clinicians, including general practitioners, neurologists, pediatricians, radiologists, psychiatrists and neuropsychologists, this will also prove a valuable tool for students, trainees and researchers.

Cerebellar Disorders
Cerebellar Disorders

Author: Mario Manto

Publisher:

Published: 2010

Total Pages: 299

ISBN-13: 9780511742194

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"This book on cerebellar disorders begins with our current understanding of the anatomy and physiology of the cerebellum, and then dives into the diagnosis and treatment of the many different disorders. As virtually all pathological processes can affect the cerebellum, the book actually covers much of neurology. Dr. Manto has been devoted to the study of the cerebellum in his career. His contributions are numerous in many areas, and his enthusiasm led him to found and edit the journal, The Cerebellum, which has rapidly become quite distinguished with an impact factor approaching 4. When dealing with the different disorders, the book approaches the patient in multiple ways. What is the differential diagnosis by age or by pathologic entity? What is the differential diagnosis for recessive, dominant, or X-linked disorders? What laboratory tests should be done to clarify the situation? What scales can be used to quantify the disorder? And then, what can be done for treatment? There is no reason to take a dim view of treatment when the possibilities are taken as a whole for all the ataxias"--Provided by publisher

Cerebellar Disorders
Cerebellar Disorders

Author: Mario Manto

Publisher:

Published: 2010

Total Pages: 299

ISBN-13: 9781316172223

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"This book on cerebellar disorders begins with our current understanding of the anatomy and physiology of the cerebellum, and then dives into the diagnosis and treatment of the many different disorders. As virtually all pathological processes can affect the cerebellum, the book actually covers much of neurology. Dr. Manto has been devoted to the study of the cerebellum in his career. His contributions are numerous in many areas, and his enthusiasm led him to found and edit the journal, The Cerebellum, which has rapidly become quite distinguished with an impact factor approaching 4. When dealing with the different disorders, the book approaches the patient in multiple ways. What is the differential diagnosis by age or by pathologic entity? What is the differential diagnosis for recessive, dominant, or X-linked disorders? What laboratory tests should be done to clarify the situation? What scales can be used to quantify the disorder? And then, what can be done for treatment? There is no reason to take a dim view of treatment when the possibilities are taken as a whole for all the ataxias"--Provided by publisher

Handbook of the Cerebellum and Cerebellar Disorders
Handbook of the Cerebellum and Cerebellar Disorders

Author: Mario U. Manto

Publisher: Springer

Published: 2021-12-05

Total Pages: 2737

ISBN-13: 9783030238094

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Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.

Handbook of the Cerebellum and Cerebellar Disorders
Handbook of the Cerebellum and Cerebellar Disorders

Author: Mario Manto

Publisher: Springer

Published: 2012-08-04

Total Pages: 0

ISBN-13: 9789400713321

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Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.

Handbook of Ataxia Disorders
Handbook of Ataxia Disorders

Author: Thomas Klockgether

Publisher: CRC Press

Published: 2000-08-18

Total Pages: 716

ISBN-13: 9781420002065

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This timely reference presents, for the first time, new findings in molecular genetics that are applicable to the epidemiology, pathogenesis, neuropathology, clinical features, and management of ataxia-bridging the gap between scientific and clinical practice. Organized by the distinctive ataxia disorders, their pathogenesis, and management-facilitating quick and efficient diagnoses! Providing complementary sections on the anatomy of the spinocerebellar system, its normal function, and a history of ataxia research and management, the Handbook of Ataxia Disorders clarifies the impact of identifying the molecular causes of ataxia offers in-depth analysis of dominant and recessive and nonhereditary ataxia disorders explores the vital connection between the genotypes and phenotypes of various degenerative ataxia disorders and more! Written by more than 60 international experts and supplemented with over 2600 literature references, photographs, micrographs, drawings, and tables, the Handbook of Ataxia Disorders is an essential and useful reference for clinical neurologists and neuropathologists, neuropediatricians, geneticists, physiatrists, and medical school students in these disciplines.

From Neurons to Neighborhoods
From Neurons to Neighborhoods

Author: National Research Council

Publisher: National Academies Press

Published: 2000-11-13

Total Pages: 610

ISBN-13: 0309069882

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How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.