The “Calcium Paradox” and its Impact on Neurological and Psychiatric Diseases (Second Edition)
The “Calcium Paradox” and its Impact on Neurological and Psychiatric Diseases (Second Edition)

Author: Leandro Bueno Bergantin

Publisher: Cambridge Scholars Publishing

Published: 2018-10-09

Total Pages: 136

ISBN-13: 1527518345

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This book extends the original concept of the “calcium paradox” discovery, herein compiling more than 300 references in the field of calcium ion (Ca2+/cAMP) signalling pathways, neurotransmission and neurodegeneration, and neurological and psychiatric diseases. In this second edition, novel illustrations and tables (highlighting current medicines for treating these diseases, including their mechanism of action) offer improved insights into the concepts for students and clinicians. The description of other neurodegenerative diseases (Spinal muscular atrophy, Amyotrophic Lateral Sclerosis and Huntington´s disease) also adds further information with regards to treating these diseases. The growing increment in the life expectancy of the world's population has increased concern about age-related neurological diseases (neurodegenerative diseases), such as Alzheimer’s (AD) and Parkinson’s (PD) diseases, among others. It is now well-recognized that an imbalance of intracellular Ca2+ homeostasis contributes to the pathogenesis of neurological diseases like neurodegenerative diseases, including AD and PD, and others. Healthy brain aging can be promoted by regular exercise, moderation in caloric intake and engaging in intellectually challenging activities. These lifestyle factors may stabilize neuronal Ca2+ homeostasis. The discovery of the role of the “calcium paradox” due to the interaction between Ca2+ and cAMP signalling pathways (Ca2+/cAMP interaction) in neurotransmission, and neuroprotection, has subsidized the understanding of pathophysiology, and pharmacology, of the neurological and psychiatric diseases, opening a large pathway for the advancement of new pharmacological strategies for the treatment of these diseases. The proposal outlined in this book involves pharmaceuticals already approved, and may, in combination with improvements in lifestyle factors, allow sustained increments in the life quality of age-related neurological patients. Finally, this book briefly discusses other aspects of Ca2+/cAMP signalling pathways, such as their possible implications on cancer.

Genetics, Neurology, Behavior, and Diet in Parkinson's Disease
Genetics, Neurology, Behavior, and Diet in Parkinson's Disease

Author: Colin R Martin

Publisher: Academic Press

Published: 2020-08-13

Total Pages: 764

ISBN-13: 0128159510

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Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson's Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson's disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease - Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about Parkinson's disease

Genetics, Neurology, Behavior, and Diet in Dementia
Genetics, Neurology, Behavior, and Diet in Dementia

Author: Colin R Martin

Publisher: Academic Press

Published: 2020-08-11

Total Pages: 954

ISBN-13: 0128158697

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Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers comprehensive coverage of a broad range of topics related to dementia - Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about dementia

The Neuroscience of Dementia
The Neuroscience of Dementia

Author: Colin R Martin

Publisher: Academic Press

Published: 2020-12-23

Total Pages: 1866

ISBN-13: 0128160446

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The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers comprehensive coverage of a broad range of topics related to dementia - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about dementia

Gabbard's Treatments of Psychiatric Disorders
Gabbard's Treatments of Psychiatric Disorders

Author: Glen O. Gabbard

Publisher: American Psychiatric Pub

Published: 2014-05-05

Total Pages: 1250

ISBN-13: 158562540X

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The definitive treatment textbook in psychiatry, this fifth edition of Gabbard's Treatments of Psychiatric Disorders has been thoroughly restructured to reflect the new DSM-5® categories, preserving its value as a state-of-the-art resource and increasing its utility in the field. The editors have produced a volume that is both comprehensive and concise, meeting the needs of clinicians who prefer a single, user-friendly volume. In the service of brevity, the book focuses on treatment over diagnostic considerations, and addresses both empirically-validated treatments and accumulated clinical wisdom where research is lacking. Noteworthy features include the following: Content is organized according to DSM-5® categories to make for rapid retrieval of relevant treatment information for the busy clinician. Outcome studies and expert opinion are presented in an accessible way to help the clinician know what treatment to use for which disorder, and how to tailor the treatment to the patient. Content is restricted to the major psychiatric conditions seen in clinical practice while leaving out less common conditions and those that have limited outcome research related to the disorder, resulting in a more streamlined and affordable text. Chapters are meticulously referenced and include dozens of tables, figures, and other illustrative features that enhance comprehension and recall. An authoritative resource for psychiatrists, psychologists, and psychiatric nurses, and an outstanding reference for students in the mental health professions, Gabbard's Treatments of Psychiatric Disorders, Fifth Edition, will prove indispensable to clinicians seeking to provide excellent care while transitioning to a DSM-5® world.

The "calcium Paradox" and Its Impact on Neurological and Psychiatric Diseases
The

Author: Leandro Bueno Bergantin

Publisher:

Published: 2018-10

Total Pages: 136

ISBN-13: 9781527513778

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This book extends the original concept of the calcium paradox discovery, herein compiling more than 300 references in the field of calcium ion (Ca2+/cAMP) signalling pathways, neurotransmission and neurodegeneration, and neurological and psychiatric diseases. In this second edition, novel illustrations and tables (highlighting current medicines for treating these diseases, including their mechanism of action) offer improved insights into the concepts for students and clinicians. The description of other neurodegenerative diseases (Spinal muscular atrophy, Amyotrophic Lateral Sclerosis and Huntingtons disease) also adds further information with regards to treating these diseases. The growing increment in the life expectancy of the world's population has increased concern about age-related neurological diseases (neurodegenerative diseases), such as Alzheimers (AD) and Parkinsons (PD) diseases, among others. It is now well-recognized that an imbalance of intracellular Ca2+ homeostasis contributes to the pathogenesis of neurological diseases like neurodegenerative diseases, including AD and PD, and others. Healthy brain aging can be promoted by regular exercise, moderation in caloric intake and engaging in intellectually challenging activities. These lifestyle factors may stabilize neuronal Ca2+ homeostasis. The discovery of the role of the calcium paradox due to the interaction between Ca2+ and cAMP signalling pathways (Ca2+/cAMP interaction) in neurotransmission, and neuroprotection, has subsidized the understanding of pathophysiology, and pharmacology, of the neurological and psychiatric diseases, opening a large pathway for the advancement of new pharmacological strategies for the treatment o

Genetics and Epigenetics of Psychiatric Diseases, 2nd Edition
Genetics and Epigenetics of Psychiatric Diseases, 2nd Edition

Author: Cunyou Zhao

Publisher: Frontiers Media SA

Published: 2020-10-09

Total Pages: 205

ISBN-13: 2889660257

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Psychiatric diseases have a highly complex etiology, aggregating in families but not segregating in a traditional Mendelian manner. Recent approaches to understanding the causes of psychiatric disease have focused on describing the genetic contribution to major psychiatric illnesses; the use of large-scale genome-wide association studies (GWAS) and exome sequencing has enabled a systematic exploration of genetic risk factors and identified over 100 independent genomic loci significantly associated with psychiatric diseases; however, there remains uncertainty about the causal genes involved in disease pathogenesis, and how their function is regulated. Since many GWAS variants reside in non-coding regions, the disease-associated common variants might be enriched in regulatory domains, including enhancers and regions of active chromatin state. These lead us to focus on the possible role of non-sequence-based genomic variation in health and disease. Of particular interest are epigenetic modifications that regulate gene expression through modifications to DNA, RNA, histone proteins, and chromatin. The availability of high-throughput profiling methods for quantifiying epigenomic modifications in large numbers of samples has enabled us to perform epigenome-wide association studies (EWAS) aimed at screening methylomic variations associated with environmental exposure and disease. Thus systematic integration of genetic, epigenetic and epidemiological approaches will contribute to improving our understanding of the molecular mechanisms underlying disease phenotypes.

Discovering the Brain
Discovering the Brain

Author: National Academy of Sciences

Publisher: National Academies Press

Published: 1992-01-01

Total Pages: 195

ISBN-13: 0309045290

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The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Childhood Cancer and Functional Impacts Across the Care Continuum
Childhood Cancer and Functional Impacts Across the Care Continuum

Author: National Academies of Sciences Engineering and Medicine

Publisher:

Published: 2021-09-09

Total Pages:

ISBN-13: 9780309683494

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Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.

A Clinical Guide to the Treatment of the Human Stress Response
A Clinical Guide to the Treatment of the Human Stress Response

Author: George S. Jr. Everly

Publisher: Springer Science & Business Media

Published: 2006-02-20

Total Pages: 482

ISBN-13: 0306478005

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This updated edition covers a range of new topics, including stress and the immune system, post-traumatic stress and crisis intervention, Eye Movement Desensitization and Reprocessing (EMDR), Critical Incident Stress Debriefing (CISD), Crisis Management Briefings in response to mass disasters and terrorism, Critical Incident Stress Management (CISM), spirituality and religion as stress management tools, dietary factors and stress, and updated information on psychopharmacologic intervention in the human stress response. It is a comprehensive and accessible guide for students, practitioners, and researchers in the fields of psychology, psychiatry, medicine, nursing, social work, and public health.