Telomeres and Telomerase
Telomeres and Telomerase

Author: Predrag Slijepcevic

Publisher: S. Karger AG (Switzerland)

Published: 2008

Total Pages: 0

ISBN-13: 9783805590631

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Telomeres are essential functional elements of eukaryotic chromosomes. Their fundamental biological role as protectors of chromosome stability was identified for the first time in the 1930s by Hermann Muller and Barbara McClintock based on pioneering cytological experiments. Modern molecular research carried out more recently revealed that telomeres and telomerase play important roles in processes such as carcinogenesis and cellular senescence. This special issue presents the most recent developments in this highly active field of research. It is becoming increasingly clear that molecular pathways involved in regulation of telomere length and structure are functionally linked with pathways involved in DNA damage response, cellular stress response, chromatin organization and perhaps even pathways that regulate evolutionary chromosome rearrangements. The above functional link is explored by the leading experts in the field of telomere biology. Cell biologists, molecular biologists, oncologists, gerontologists, and radiobiologists with an interest in the role of telomeres/telomerase will appreciate the up-to-date information in this publication.

Telomerases
Telomerases

Author: Neal F. Lue

Publisher: John Wiley & Sons

Published: 2012-05-22

Total Pages: 334

ISBN-13: 1118267516

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This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.

Telomerase Inhibition
Telomerase Inhibition

Author: Lucy Andrews

Publisher: Springer Science & Business Media

Published: 2007-11-29

Total Pages: 197

ISBN-13: 1588296830

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This volume presents a compendium of the most recent and advanced methods applied to the rapidly expanding field of telomerase inhibition. The techniques described provide the researcher with a diverse and comprehensive set of tools for the study of telomerase inhibition. The volume is aimed at biochemists, molecular biologists, cancer researchers, and geneticists.

Telomerases
Telomerases

Author: Neal F. Lue

Publisher: John Wiley & Sons

Published: 2012-06-26

Total Pages: 334

ISBN-13: 0470592044

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This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.

Up
Up

Author: Hilary Tindle

Publisher: Penguin

Published: 2013-05-30

Total Pages: 268

ISBN-13: 1101623632

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Why looking up matters A positive attitude is important, but until now we didn’t know how important. In Up, a practicing physician and NIH-funded researcher draws on her research and experience to show that our outlook on life— our unique patterns of thinking and feeling about ourselves, others, and the world—may be the key to how well and how fast we age. From wrinkles to cognitive decline, our outlook affects our health at every level. Using the framework of outlook GPS, Up illustrates how we can gauge our current attitude latitude and move to healthier ground. Tindle brings a fresh eye to attitudinal traits such as optimism, noting that it has many faces, including the face of her own struggling optimism. Using the 7 Steps of Attitudinal Change that she applies to her own patients, Tindle offers us a path toward healthy aging. Prescriptive and accessible, Up puts forward a paradigm shift in how we age and treat disease, giving even the most struggling optimists a chance for hope. It will appeal to readers of The Longevity Project by Howard S. Friedman and Leslie R. Martin as well as The Blue Zones by Dan Buettner.

RNA Motifs and Regulatory Elements
RNA Motifs and Regulatory Elements

Author: Thomas Dandekar

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 234

ISBN-13: 3642562981

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RNA Motifs and Regulatory Elements is the new edition of the successful book, "Regulatory RNA". It alerts the reader to the importance of regulatory RNA elements for the many different areas of cellular life. The computational and experimental methods and tools to search for new interesting regulatory RNA structures are explained and compared. The knowledge on regulatory RNA structures and elements already available is concisely summarized as well as catalogued. In addition, interesting RNA elements are analyzed in detail regarding their dynamics, regulation, and as a dominant topic of current resarch in molecular biology, including areas such as RNA mediated regulation of gene-expression, DNA/RNA chip data, and ribozymes, splicing, or telomerases in aging. Medical implications are also covered. Future progress and research are finally outlined.

Telomeres and Telomerase in Cancer
Telomeres and Telomerase in Cancer

Author: Keiko Hiyama

Publisher: Springer Science & Business Media

Published: 2009-03-18

Total Pages: 375

ISBN-13: 1603278796

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Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

The Telomerase Revolution
The Telomerase Revolution

Author: Michael Fossel

Publisher: Atlantic Books Ltd

Published: 2015-10-06

Total Pages: 281

ISBN-13: 1782399119

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Science is on the cusp of a revolutionary breakthrough. We now understand more about ageing - and how to prevent and reverse it - than ever before. In The Telomerase Revolution, Dr Michael Fossel, who has been at the cutting edge of ageing research for decades, describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to intervene in age-related disease, dramatically extend life spans and even reverse human ageing. Telomerase-based treatments are already on offer, and have shown early promise, but much more potent treatments will become available over the next decade. This is the definitive work on the latest science of human ageing, covering both the theory and the clinical implications, taking readers to the forefront of one of the most remarkable advances in human medicine.

Biochemistry and Cell Biology of Ageing: Part I Biomedical Science
Biochemistry and Cell Biology of Ageing: Part I Biomedical Science

Author: J. Robin Harris

Publisher: Springer

Published: 2019-02-18

Total Pages: 531

ISBN-13: 9811328358

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This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Textbook Of Structural Biology (Second Edition)
Textbook Of Structural Biology (Second Edition)

Author: Anders Liljas

Publisher: World Scientific

Published: 2016-09-27

Total Pages: 610

ISBN-13: 9813142499

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This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids.There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology.The book covers state-of-the-art research in various areas. It is unique for its breadth of coverage by experts in the fields. The book is richly illustrated with more than 400 color figures to highlight the wide range of structures.