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Author: Carmelo Nucera
Publisher: Frontiers Media SA
Published:
Total Pages: 133
ISBN-13: 2889661989
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Publisher:
Published: 2014
Total Pages: 131
ISBN-13:
DOWNLOAD EBOOKAuthor: Anne Le
Publisher: Springer
Published: 2018-06-26
Total Pages: 186
ISBN-13: 331977736X
DOWNLOAD EBOOKGenetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author: Kelly Power-Kean
Publisher: Elsevier Health Sciences
Published: 2022-01-08
Total Pages: 1229
ISBN-13: 0323778852
DOWNLOAD EBOOK**Textbook and Academic Authors Association (TAA) Textbook Excellence Award Winner, 2024** Prepare for Canadian nursing practice with a solid understanding of pathophysiology and disease! Huether and McCance's Understanding Pathophysiology, 2nd Canadian Edition covers the basic concepts of pathophysiology and disease processes from a Canadian perspective. Clear descriptions and vibrant illustrations make it easier to understand body systems and the mechanisms of disease, and online resources bring pathophysiology concepts to life. Developed for Canadian nursing students by educators Kelly Power-Kean, Stephanie Zettel, and Mohamed Toufic El-Hussein, this text prepares students for success on the Next Generation NCLEX®, CPNRE®, and REx-PNTM and also in clinical practice. - Introduction to Pathophysiology provides an entrance to the science of pathophysiology and explains why it is important. - Lifespan coverage includes nine separate chapters on developmental alterations in pathophysiology and special sections with aging and pediatrics content. - Canadian drug and treatment guidelines familiarize you with aspects of clinical practice you will encounter. - Coverage of diseases includes their pathophysiology, clinical manifestations, and evaluation and treatment. - Canadian lab values provide the core fundamental information required for practice in Canada. - Canadian morbidity statistics provide you with the Canadian context in which you will be practising. - Algorithms and flowcharts of diseases and disorders make it easy to follow the sequential progression of disease processes. - Health Promotion boxes emphasize evidence-based care and align with the Canadian curriculum. - Risk Factors boxes highlight important safety considerations associated with specific diseases. - Quick Check boxes test your understanding of important chapter concepts. - End-of-chapter Did You Understand? summaries make it easy to review the chapter's major concepts. - Key Terms are set in blue, boldface type and listed at the end of each chapter - Glossary of approximately 1,000 terms is included on the Evolve website with definitions of important terminology.
Author: A. Pinchera
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 579
ISBN-13: 146130945X
DOWNLOAD EBOOKIn 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an International Symposium on Thyroid Autoimmunity was held in Pisa. Its purpose was to commemorate the birth of thyroid autoimmunity as a scientific discipline, to summarize current knowledge and concepts in this area, and where possible, to anticipate areas of opportunity for the future - hence the theme of the Symposium, Memories and Perspectives. To open the meeting, the Magnifico Rettore (Chancellor) of the University of Pisa granted special Awards to Dr. Deborah Doniach, Dr. Ivan Roitt, and Dr. Noel R. Rose, who published the first fundamental studies in the field of thyroid autoimmunity, and to Dr. Duncan G. Adams, whose discovery of the long-acting thyroid stimulator (LATS) opened the door to our current understanding of the pathogenesis of Graves' disease. During the meeting thirty plenary lectures were presented.
Author: John P. Bilezikian
Publisher: Academic Press
Published: 2008-09-29
Total Pages: 2074
ISBN-13: 0080568750
DOWNLOAD EBOOKPrinciples of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. - Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field - The essential resource for anyone involved in the study of bones and bone diseases - Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics - Readers can easily search and locate information quickly as it will be online with this new edition
Author: Tanya Vavouri
Publisher: Humana Press
Published: 2018-04-01
Total Pages: 340
ISBN-13: 9781493977673
DOWNLOAD EBOOKThis detailed volume examines bioinformatic and molecular biological methods useful to identify and to explore the functions of CpG islands, key navigation points to understand gene regulation in fundamental processes such as development and cell differentiation as well as in diseases like cancer. Beginning with a historical perspective and important properties of CpG islands, the book continues with sections on computational and wet lab methods related to the study of DNA methylation, and in-depth protocols for the analysis of CpG island functional features including epigenetic profiling and chromatin interactions. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, CpG Islands: Methods and Protocols aims to provide readers with the information and methodologies necessary to continue to decipher how a genome’s structure and organization contribute to regulate biological processes.
Author: Eric J. Bieber
Publisher: Cambridge University Press
Published: 2015-04-23
Total Pages: 1127
ISBN-13: 1107040396
DOWNLOAD EBOOKWritten with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
Author:
Publisher:
Published: 1997
Total Pages: 84
ISBN-13:
DOWNLOAD EBOOKAuthor: Bruce A. Chabner
Publisher: Lippincott Williams & Wilkins
Published: 2011-12-07
Total Pages: 836
ISBN-13: 1451148208
DOWNLOAD EBOOKUpdated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.
