Targeting Oral Cancer
Targeting Oral Cancer

Author: Andrew Fribley

Publisher: Springer

Published: 2016-02-29

Total Pages: 303

ISBN-13: 3319276476

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This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of HPV in oral cancer and explains the surgical, chemotherapy and radiation approaches to treatment. Aspects such as molecular progression, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation.

Textbook of Oral Cancer
Textbook of Oral Cancer

Author: Saman Warnakulasuriya

Publisher: Springer Nature

Published: 2020-02-22

Total Pages: 449

ISBN-13: 3030323161

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This comprehensive multidisciplinary book examines all aspects of cancers of the mouth and oropharynx with the aim of equipping advanced students and practitioners in the early stages of specialist training with an up-to-date guide and reference. A multinational team of authors – all experts in the field of oral oncology – provide illuminating contributions on the full range of relevant topics: epidemiology, risk factors, clinical features, staging and prognostic factors, pathology, diagnostic techniques, disease prevention, surgery, radiotherapy, and chemotherapy. Molecular biology, molecular targeted therapies for advanced cases, and future diagnostic and prognostic applications of new technologies also receive careful attention. In providing a wealth of essential information and guidance in a practical format, the book will be a superb asset for senior graduate students in dentistry and specialist trainees in head and neck oncology. It will also be of high value for the many physicians, surgeons, pathologists, dentists, and specialists involved in the prevention, diagnosis, and management of squamous cell carcinomas of the oral cavity and oropharynx.

Screening for Oral Cancer
Screening for Oral Cancer

Author: U. S. Department of Health and Human Services

Publisher: Createspace Independent Publishing Platform

Published: 2013-05-28

Total Pages: 38

ISBN-13: 9781489591555

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In 2004, the U.S Preventive Services Task Force (USPSTF) found insufficient evidence in its review to recommend for or against screening for oral cancer. In this review, we are updating the evidence search and analysis to allow this recommendation to be reconsidered. Oral cancer includes cancers of the lip, oral cavity, and pharynx. Ninety percent of cancers of the oral cavity are squamous cell carcinomas (SCCs) arising from the mucosal lining. The other 10 percent of oral cancers are malignant melanomas, salivary gland tumors, sarcomas of the soft tissues or jaw bones, nonHodgkin's lymphomas, or metastases from extra-oral primary tumors. The USPSTF requested this targeted update to focus on the evidence gap in the conceptual framework about screening for oral cancer (i.e., any test or combination of tests used to detect PMDs or cancer of the lip, oral cavity, or pharynx). The two key questions are: Key Question 1 (KQ 1): Does screening for oral cancer reduce morbidity or mortality? Key Question 2 (KQ 2): What are the performance characteristics of the screening oral examination as a means of identifying oral cancer or PMDs for oral cancer?

Development of Oral Cancer
Development of Oral Cancer

Author: Ala-Eddin Al Moustafa

Publisher: Springer

Published: 2017-08-03

Total Pages: 219

ISBN-13: 3319480545

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This book aims to provide the reader with a complete understanding of the development of oral cancer by explaining the role of a wide variety of implicated risk factors and identifying their gene targets and key regulators. Some of the discussed risk factors are well known, including smoking, alcohol, betel quid chewing, and oncoviruses such as high-risk human papillomaviruses and Epstein-Barr virus; however, careful attention is also paid to less widely recognized factors, such as Qat chewing and yerba Mate consumption. The book concludes by describing and evaluating the most important strategies currently available for the prevention of oral carcinogenesis in humans. In presenting the most up-todate research and knowledge on these topics, this book will serve as a valuable source of up-to-date information for oncologists, cancer scientists, and medical students.

Oral and Maxillofacial Surgery for the Clinician
Oral and Maxillofacial Surgery for the Clinician

Author: Krishnamurthy Bonanthaya

Publisher: Springer Nature

Published: 2021

Total Pages: 1965

ISBN-13: 9811513465

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This is an open access book with CC BY 4.0 license. This comprehensive open access textbook provides a comprehensive coverage of principles and practice of oral and maxillofacial surgery. With a range of topics starting from routine dentoalveolar surgery to advanced and complex surgical procedures, this volume is a meaningful combination of text and illustrations including clinical photos, radiographs, and videos. It provides guidance on evidence-based practices in context to existing protocols, guidelines and recommendations to help readers deal with most clinical scenarios in their daily surgical work. This multidisciplinary textbook is meant for postgraduate trainees, young practicing oral surgeons and experienced clinicians, as well as those preparing for university and board certification exams. It also aids in decision-making, the implementation of treatment plans and the management of complications that may arise. This book is an initiative of Association of Oral and Maxillofacial Surgeons of India (AOMSI) to its commitment to academic medicine. As part of this commitment, this textbook is in open access to help ensure widest possible dissemination to readers across the world. ; Open access Unique presentation with contents divided into color-coded core competency gradations Covers all aspects of oral and maxillofacial surgery Supplemented with videos of all commonly carried out procedures as operative video Every chapter or topic concludes with "future perspective" and addresses cutting edge advances in each area Every topic has a pull out box that provides the most relevant systematic reviews/ key articles to every topic.

Controversies in Oral Cancer
Controversies in Oral Cancer

Author: K. Alok Pathak

Publisher: Springer

Published: 2015-10-30

Total Pages: 137

ISBN-13: 8132225740

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This volume brings together the work of experts from clinical and basic sciences specialties and addresses some of the controversial issues and advances in the management of oral cancer. Improving the outcome for the oral cancer patient will require dedicated work from many disciplines working together as multidisciplinary units. The book is meant for medical students, residents and consultants in various disciplines, including otolaryngology, head and neck surgery, neurosurgery, plastic surgery, maxillofacial surgery and oncology.

Oral Cancer Detection
Oral Cancer Detection

Author: Prashanth Panta

Publisher: Springer

Published: 2019-01-04

Total Pages: 314

ISBN-13: 3319612557

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This monograph equips clinicians with the knowledge required to detect oral cancer at the earliest possible stage while simultaneously inspiring researchers to work on novel methods of detection. All the methods employed in the oral cancer context are considered, from simple ones like oral screening to more complex emerging optical methods and biomarker identification strategies. Individual chapters focus on conventional oral screening and application of vital stains, optical methods like white light based fluorescence-reflectance imaging, narrow band imaging, direct-oral-microscopy, and more advanced methods like optical coherence tomography, an in-vivo optical biopsy technique, and photo-acoustic imaging that allows visualization of deeper tissue changes. Novel electrical methods like bio-impedance assessment, occult biophysical methods like crystallization test, and the most promising salivary biomarkers and point-of-care opportunities are covered. Helpful information is also provided on essential topics including, oral potentially malignant disorders, biological aspects and molecular mechanisms underlying oral cancer progression, global epidemiology, concept of diagnostic delays, traditional imaging, and classic histopathology and microscopic features. The newer techniques are currently of active research interest, and can soon become powerful chair-side tools with potential to reduce diagnostic delays and improve survival.

Inflammation and Oral Cancer
Inflammation and Oral Cancer

Author: Hiroyuki Tomita

Publisher: Academic Press

Published: 2021-12-15

Total Pages: 200

ISBN-13: 9780323885263

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Inflammation and Oral Cancer: From Bench to Bedside discusses all aspects surrounding the relationship between inflammation and oral cancer, from basic science to the translational research that helps in the optimization of clinical management strategies. The book discusses topics such as chronic inflammation and cancer in oral cavity, the role of HPV in oral inflammation and cancer, rodent models of oral cancer, and epigenetics in oral inflammation and cancer. This is a valuable resource for cancer researchers, oncologists and members of biomedical field who are interested in learning more about the diverse aspects of inflammation and oral cancer. Inflammation in oral mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it can have fundamental clinical consequences, the principal of which can be premalignant lesions throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for oral cancer - therefore it is very important to understand these interactions in detail. Presents animal models of oral cancers for use in research Discusses epigenetics in oral cancers, along with risk factors such as tabaco and alcohol Encompasses detailed information on human papilloma virus (HPV) and its risk in oral inflammation and cancer

Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines
Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines

Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Publisher: IARC

Published: 2004

Total Pages: 354

ISBN-13: 9789283212850

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A working group of sixteen experts from seven countries re-evaluated the evidence of the carcinogenicity of betel-quid and areca-nut chewing and some areca-nut related nitrosamines. Betel-quid and areca-nut chewing are widely practised in many parts of Asia and in Asian-migrant communities elsewhere in the world. There are hundreds of millions of users worldwide. They evaluated betel quid with tobacco as carcinogenic to humans (Group 1) on the basis of sufficient evidence of an increased risk of cancer of the oral cavity, pharynx and oesophagus. The working group reviewed epidemiological studies of human cancer, mainly studies from India, Pakistan and Taiwan (China). Studies on betel quid with tobacco and areca nut with tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. The working group also evaluated betel quid without tobacco as carcinogenic to humans (Group 1), on the basis of sufficient evidence of an increased risk of oral cancer. Studies on betel quid without tobacco and areca nut without tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. Areca nut, a common ingredient of betel quid and many different chewing preparations, including those available commercially, has been observed to cause oral submucous fibrosis