Synthetic Biology of Yeasts for the Production of Non-Native Chemicals, 2nd Edition
Author: Farshad Darvishi
Publisher: Frontiers Media SA
Published: 2021-10-22
Total Pages: 137
ISBN-13: 2889713245
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Synthetic Biology of Yeasts
Author: Farshad Darvishi Harzevili
Publisher: Springer
Published: 2023-01-23
Total Pages: 0
ISBN-13: 9783030896829
DOWNLOAD EBOOKThis book covers recent advances and future trends in yeast synthetic biology, providing readers with an overview of computational and engineering tools, and giving insight on important applications. Yeasts are one of the most attractive microbial cell factories for the production of a wide range of valuable products, including pharmaceuticals, nutraceuticals, cosmetics, agrochemicals and biofuels. Synthetic biology tools have been developed to improve the metabolic engineering of yeasts in a faster and more reliable manner. Today, these tools are used to make synthetic pathways and rewiring metabolism even more efficient, producing products at high titer, rate, and yield. Split into two parts, the book opens with an introduction to rational metabolic pathway prediction and design using computational tools and their applications for yeast systems and synthetic biology. Then, it focuses on the construction and assembly of standardized biobricks for synthetic pathway engineering in yeasts, yeast cell engineering and whole cell yeast-based biosensors. The second part covers applications of synthetic biology to produce diverse and attractive products by some well-known yeasts. Given its interdisciplinary scope, the book offers a valuable asset for students, researchers and engineers working in biotechnology, applied microbiology, metabolic engineer ing and synthetic biology.
Studies in Natural Products Chemistry
Author: Atta-ur Rahman
Publisher: Elsevier
Published: 2022-07-19
Total Pages: 500
ISBN-13: 0323911005
DOWNLOAD EBOOKNatural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores
Non-conventional Yeasts: from Basic Research to Application
Author: Andriy Sibirny
Publisher: Springer
Published: 2019-08-12
Total Pages: 568
ISBN-13: 303021110X
DOWNLOAD EBOOKThis volume scopes several aspects of non-conventional yeast research prepared by the leading specialists in the field. An introduction on taxonomy and systematics enhances the reader’s knowledge on yeasts beyond established ones such as Saccharomyces cerevisiae. Biotechnological approaches that involve fungal utilization of unusual substrates, production of biofuels and useful chemicals as citric acid, glutathione or erythritol are discussed. Further, strategies for metabolic engineering based on knowledge on regulation of gene expression as well as sensing and signaling pathways are presented. The book targets researchers and advanced students working in Microbiology, Microbial Biotechnology and Biochemistry.
Synthetic Biology of Yeasts
Author: Farshad Darvishi Harzevili
Publisher: Springer Nature
Published: 2022-01-21
Total Pages: 377
ISBN-13: 3030896803
DOWNLOAD EBOOKThis book covers recent advances and future trends in yeast synthetic biology, providing readers with an overview of computational and engineering tools, and giving insight on important applications. Yeasts are one of the most attractive microbial cell factories for the production of a wide range of valuable products, including pharmaceuticals, nutraceuticals, cosmetics, agrochemicals and biofuels. Synthetic biology tools have been developed to improve the metabolic engineering of yeasts in a faster and more reliable manner. Today, these tools are used to make synthetic pathways and rewiring metabolism even more efficient, producing products at high titer, rate, and yield. Split into two parts, the book opens with an introduction to rational metabolic pathway prediction and design using computational tools and their applications for yeast systems and synthetic biology. Then, it focuses on the construction and assembly of standardized biobricks for synthetic pathway engineering in yeasts, yeast cell engineering and whole cell yeast-based biosensors. The second part covers applications of synthetic biology to produce diverse and attractive products by some well-known yeasts. Given its interdisciplinary scope, the book offers a valuable asset for students, researchers and engineers working in biotechnology, applied microbiology, metabolic engineer ing and synthetic biology.
Synthetic Biology and Metabolic Engineering for the Production of Fuels and Chemicals
Author: Gabriel Manuel Rodriguez
Publisher:
Published: 2014
Total Pages:
ISBN-13: 9781321609790
DOWNLOAD EBOOKDwindling supplies of finite petroleum resources necessitate alternative sources for the production of chemicals and fuels. Today 99% of all chemicals are derived from petroleum1. Chemicals are used to make products such as rubbers, plastics, adhesives, paints, coatings, pharmaceuticals, and fragrances that contribute to our higher standard of living. Ultimately, society will need to derive chemicals from carbon dioxide from the atmosphere, either through photosynthesis or electricity. Currently, photosynthesis offers the most efficient method for converting carbon dioxide to useful chemicals. Advances in synthetic biology have enabled the biological production of chemicals and fuels by rationally introducing genes and other genetic parts from various sources in nature into user-friendly microorganisms such as Escherichia coli and Saccharomyces cerevisiae. Metabolic engineering approaches then tune the metabolism of the microorganism by eliminating competing pathways while maintaining energy balance and cell fitness. The marriage of these techniques has enabled the production of a multitude of chemicals and fuels from microorganisms such as E. coli. In this dissertation, I describe recent advances in synthetic biology and metabolic engineering geared toward the production of fuels and chemicals from E. coli along with my contributions to the field. I have made contributions in three major ways: 1.) Strain engineering for the production chemicals in E coli, 2.) Elucidation of yet unknown genes in E. coli, and 3.) Developing new biosynthetic pathways for the biological production of esters.
Genetic Transformation Systems in Fungi, Volume 2
Author: Marco A. van den Berg
Publisher: Springer
Published: 2014-10-31
Total Pages: 275
ISBN-13: 3319105035
DOWNLOAD EBOOKFungi are an economic very important class of microbes. Not only do they host a range of versatile enzymes used in industrial applications (biofuels, laundry, food processing), as well do they produce several very important pharmaceutical drugs (statins and penicillins). Moreover, fungal pathogens can cause great damage in agricultural production (Phytophthora and Botrytis) and during mammalian infections (Penicillium marneffei and Candida). Transformation of DNA is used to understand the genetic basis behind these traits. Several different techniques have been developed over the years and readily shown to be decisive methods to improve fungal biotechnology. This book will cover the basics behind the most commonly used transformation methods, as well as associated tools and techniques. Each chapter will provide protocols along with examples to be used in laboratories worldwide.
Systems Metabolic Engineering
Author: Christoph Wittmann
Publisher: Springer Science & Business Media
Published: 2012-06-15
Total Pages: 391
ISBN-13: 9400745346
DOWNLOAD EBOOKSystems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.
Biodefense in the Age of Synthetic Biology
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Published: 2019-01-05
Total Pages: 189
ISBN-13: 0309465184
DOWNLOAD EBOOKScientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.
Fermentation Microbiology and Biotechnology, Fourth Edition
Author: E. M. T. El-Mansi
Publisher: CRC Press
Published: 2018-12-17
Total Pages: 662
ISBN-13: 042901595X
DOWNLOAD EBOOKFermentation Microbiology and Biotechnology, 4th Edition explores and illustrates the broad array of metabolic pathways employed for the production of primary and secondary metabolites, as well as biopharmaceuticals. This updated and expanded edition addresses the whole spectrum of fermentation biotechnology, from fermentation kinetics and dynamics to protein and co-factor engineering. It also sheds light on the new strategies employed by industrialist for increasing tolerance and endurance of microorganisms to the accumulation of toxic wastes in microbial-cell factories. The new edition builds upon the fine pedigree of its earlier predecessors and extends the spectrum of the book to reflect the multidisciplinary and buoyant nature of this subject area. Key Features Covers the whole spectrum of the field from fermentation kinetics to control of fermentation and protein engineering. Includes case studies specifically designed to illustrate industrial applications and current state-of-the-art technologies. Presents the contributions of eminent international academics and industrial experts. Offers new chapters addressing: The prospects and the role of bio-fuels refineries, Control of metabolic efflux to product formation in microbial-cell factories and Improving tolerance of microorganisms to toxic byproduct accumulation in the fermentation vessel.
