Histamine in the brain

Histamine in the brain

Author: Jian-Sheng Lin

Publisher: Frontiers Media SA

Published: 2015-03-18

Total Pages: 100

ISBN-13: 2889194345

DOWNLOAD EBOOK

Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.


Cellular Migration and Formation of Neuronal Connections

Cellular Migration and Formation of Neuronal Connections

Author:

Publisher: Academic Press

Published: 2013-05-06

Total Pages: 1081

ISBN-13: 0123973473

DOWNLOAD EBOOK

The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity


Neuroplasticity

Neuroplasticity

Author: Victor Chaban

Publisher: BoD – Books on Demand

Published: 2018-06-06

Total Pages: 206

ISBN-13: 1789231949

DOWNLOAD EBOOK

This book provides comprehensive and up-to-date insights into emerging research trends on neuroplasticity with current or future treatments for neurodevelopment and neurodegenerative diseases. The authors discuss structural and functional changes associated with cortical remapping, sensory substitution, synaptic and non-synaptic compensatory plasticity due to brain damage, brain training, chronic pain, meditation, music, exercise and related states. Key features include pathogenesis, and existing and new therapies together with a pharmacological and non-pharmacological approach in clinical treatment and management. The authors are established experts that contributed significantly to a better understanding of the etiology of neuroplasticity. This book is recommended to healthcare providers, clinical scientists, students and patients.


Cyclin Dependent Kinase 5 (Cdk5)

Cyclin Dependent Kinase 5 (Cdk5)

Author: Nancy Y. Ip

Publisher: Springer Science & Business Media

Published: 2009-02-28

Total Pages: 326

ISBN-13: 0387788875

DOWNLOAD EBOOK

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.


Seizures and Epilepsy

Seizures and Epilepsy

Author: Jerome Engel Jr

Publisher: Oxford University Press

Published: 2013-01-31

Total Pages: 737

ISBN-13: 019532854X

DOWNLOAD EBOOK

This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.


Synaptic Transmission

Synaptic Transmission

Author: Stephen D. Meriney

Publisher: Academic Press

Published: 2019-06-12

Total Pages: 530

ISBN-13: 0128153210

DOWNLOAD EBOOK

Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders. - Provides a comprehensive reference on synaptic structure, physiology, function and neurotransmission - Discusses many landmark experiments in the field of synaptic transmission to emphasize core principles - Includes references to primary scientific literature, relevant review articles and books, many of which could be assigned as discussion material for courses focused on this topic


Psychiatry, Psychoanalysis, and the New Biology of Mind

Psychiatry, Psychoanalysis, and the New Biology of Mind

Author: Eric R. Kandel

Publisher: American Psychiatric Pub

Published: 2008-05-20

Total Pages: 450

ISBN-13: 1585626848

DOWNLOAD EBOOK

Brought together for the first time in a single volume, these eight important and fascinating essays by Nobel Prize-winning psychiatrist Eric Kandel provide a breakthrough perspective on how biology has influenced modern psychiatric thought. Complete with commentaries by experts in the field, Psychiatry, Psychoanalysis, and the New Biology of Mind reflects the author's evolving view of how biology has revolutionized psychiatry and psychology and how potentially could alter modern psychoanalytic thought. The author's unique perspective on both psychoanalysis and biological research has led to breakthroughs in our thinking about neurobiology, psychiatry, and psychoanalysis -- all driven by the central idea that a fuller understanding of the biological processes of learning and memory can illuminate our understanding of behavior and its disorders. These wonderful essays cover the mechanisms of psychotherapy and medications, showing that both work at the same level of neural circuits and synapses, and the implications of neurobiological research for psychotherapy; the ability to detect functional changes in the brain after psychotherapy, which enables us, for the first time, to objectively evaluate the effects of psychotherapy on individual patients; the need for animal models of mental disorders; for example, learned fear, to show how molecules and cellular mechanisms for learning and memory can be combined in various ways to produce a range of adaptive and maladaptive behaviors; the unification of behavioral psychology, cognitive psychology, neuroscience, and molecular biology into the new science of the mind, charted in two seminal reports on neurobiology and molecular biology given in 1983 and 2000; the critical role of synapses and synaptic strength in both short- and long-term learning; the biological and social implications of the mapping of the human genome for medicine in general and for psychiatry and mental health in particular; The author concludes by calling for a revolution in psychiatry, one that can use the power of biology and cognitive psychology to treat the many mentally ill persons who do not benefit from drug therapy. Fascinating reading for psychiatrists, psychoanalysts, social workers, residents in psychiatry, and trainees in psychoanalysis, Psychiatry, Psychoanalysis, and the New Biology of Mind records with elegant precision the monumental changes taking place in psychiatric thinking. It is an invaluable reference work and a treasured resource for thinking about the future.