Studies on Hepatitis Viruses

Studies on Hepatitis Viruses

Author: Satya Prakash Gupta

Publisher: Academic Press

Published: 2018-06-20

Total Pages: 244

ISBN-13: 0128133317

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Studies on Hepatitis Viruses: Life Cycle, Structure, Functions, and Inhibition presents the latest on this systemic infection that predominantly affects the liver with inflammation that can be acute or chronic. Hepatitis viruses have been the subject of intense study in the last twenty years, with a wealth of information related to their lifecycle, structure, functions and inhibition being presented. This book compiles the most important developments and research, giving users a very useful guide on this evolving area of virology and medicinal chemistry. - Provides comprehensive, state-of-the-art coverage of hepatitis virus infections, the virus' lifecycle, and mechanisms of protease inhibition - Analyzes structure-activity relationships of inhibitors of viral hepatitis - Presents an in-depth view of the structure and function of viral hepatitis - Discusses classification, epidemiology, pathogenesis, natural history, clinical manifestations, diagnosis, complications, associated disorders and animal models


Guidelines on Hepatitis B and C Testing

Guidelines on Hepatitis B and C Testing

Author: World Health Organization

Publisher: World Health Organization

Published: 2017

Total Pages: 0

ISBN-13: 9789241549981

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Testing and diagnosis of hepatitis B (HBV) and C (HCV) infection is the gateway for access to both prevention and treatment services, and is a crucial component of an effective response to the hepatitis epidemic. Early identification of persons with chronic HBV or HCV infection enables them to receive the necessary care and treatment to prevent or delay progression of liver disease. Testing also provides an opportunity to link people to interventions to reduce transmission, through counselling on risk behaviors and provision of prevention commodities (such as sterile needles and syringes) and hepatitis B vaccination. These are the first WHO guidelines on testing for chronic HBV and HCV infection and complement published guidance by WHO on the prevention, care and treatment of chronic hepatitis C and hepatitis B infection. These guidelines outline the public health approach to strengthening and expanding current testing practices for HBV and HCV, and are intended for use across age groups and populations.


Eliminating the Public Health Problem of Hepatitis B and C in the United States

Eliminating the Public Health Problem of Hepatitis B and C in the United States

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2016-06-01

Total Pages: 187

ISBN-13: 0309438020

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Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.


Hepatitis and Liver Cancer

Hepatitis and Liver Cancer

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2010-04-23

Total Pages: 252

ISBN-13: 0309153689

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The global epidemic of hepatitis B and C is a serious public health problem. Hepatitis B and C are the major causes of chronic liver disease and liver cancer in the world. In the next 10 years, 150,000 people in the United States will die from liver disease or liver cancer associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. Today, between 800,000 and 1.4 million people in the United States have chronic hepatitis B and between 2.7 and 3.9 million have chronic hepatitis C. People most at risk for hepatitis B and C often are the least likely to have access to medical services. Reducing the rates of illness and death associated with these diseases will require greater awareness and knowledge among health care workers, improved identification of at-risk people, and improved access to medical care. Hepatitis B is a vaccine-preventable disease. Although federal public health officials recommend that all newborns, children, and at-risk adults receive the vaccine, about 46,000 new acute cases of the HBV infection emerge each year, including 1,000 in infants who acquire the infection during birth from their HBV-positive mothers. Unfortunately, there is no vaccine for hepatitis C, which is transmitted by direct exposure to infectious blood. Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of HBV and HCV infections. The book presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis. It identifies priorities for research, policy, and action geared toward federal, state, and local public health officials, stakeholder, and advocacy groups and professional organizations.


Hepatitis B

Hepatitis B

Author: Baruch S. Blumberg

Publisher: Princeton University Press

Published: 2002

Total Pages: 274

ISBN-13: 9780691116235

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About 375 million people are infected with the hepatitis B virus. It has killed more people than AIDS and also causes millions of cases of liver cancer. The discovery of this deadly virus and the vaccine against it--a vaccine that is sharply decreasing the infection rate worldwide and is probably the first effective cancer vaccine--was one of the great triumphs of twentieth-century medicine. And it almost didn't happen. With wit and insight, this scientific memoir and story of discovery describes how Baruch Blumberg and a team of researchers found a virus they were not looking for and created a vaccine for a disease they previously knew little about--work that took the author around the world and won him the Nobel Prize. Blumberg and his collaborators were investigating relationships between gene distribution and disease susceptibility, research that was yielding interesting data but no real breakthroughs. Many viewed their work as more field trip than science. But, through decades of hard work and investigative twists and turns, their pursuit led to the hepatitis B antigen, the elusive virus itself, and, ultimately, the vaccine. As he takes the reader through the detective work that culminated in his incredible discovery, the author recounts with immediacy exciting moments in the lab and in the field--from a hair-raising flight to Africa to an unpleasant encounter with Alaskan sled dogs. The hepatitis B story is more than a fascinating chronicle of a major discovery. What Blumberg followed to the virus was a trail of remarkable "accidents" that happen when scientists seek answers to interesting questions. Those events, combined with the investigator's determined persistence, resulted in studies that generated a pharmaceutical industry, have far-flung public-health applications, and saved millions of lives.


Liver Disease in Children

Liver Disease in Children

Author: Frederick J. Suchy

Publisher: Cambridge University Press

Published: 2007-05-07

Total Pages: 995

ISBN-13: 1139464035

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Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.


Enteric Hepatitis Viruses

Enteric Hepatitis Viruses

Author: Stanley M. Lemon

Publisher: Perspectives Cshl

Published: 2018

Total Pages: 400

ISBN-13: 9781621821625

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"A subject collection from Cold Spring Harbor Perspectives in Medicine"--title page.


Chronic Viral Hepatitis

Chronic Viral Hepatitis

Author: Raymond Steven Koff

Publisher: Springer Science & Business Media

Published: 2002

Total Pages: 360

ISBN-13:

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Around the world hepatitis has infected more than 2 billion people (10 million in the US) and is, in its chronic form, the leading factor in end-stage liver disease and the rising incidence of hepatocellular carcinoma. In Chronic Viral Hepatitis: Diagnosis and Therapeutics, leading scientists, clinicians, and clinical investigators comprehensively review the epidemiology, molecular virology, diagnosis, treatment, and prevention of chronic hepatitis caused by the B and C viruses. The discussion of patient management includes contributions on developing novel therapeutics, supporting patients during therapy, alternative treatments, the use of drugs in chronic viral hepatitis, liver transplantation, and pregnancy in chronic viral hepatitis. Attention is also given to the treatment of patients with concomitant autoimmune disorders, the management of HIV co-infection, and the management of HBV/HCV co-infection. Each chapter provides an extensive review of available literature and is based on broad experience in clinical trials and the management of patients with chronic viral hepatitis. Authoritative and eminently practical, Chronic Viral Hepatitis: Diagnosis and Therapeutics offers today's gastroenterologists, primary care physicians, hepatologists, and infectious disease specialists a critical understanding of the state-of-the-art in chronic viral hepatitis and insightful projections of the many powerful new therapeutics now emerging.