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Author: Mervyn W Billinghurst
Publisher: CRC Press
Published: 2017-11-22
Total Pages: 260
ISBN-13: 1351357549
DOWNLOAD EBOOKThis volume is the result of the concerted effeort of a number os scientists to summarize in a succinct way the current understanding of the mechanisms of these localizations. The editors of the book gratefully acknowledge this combined effort.
Author: William C. Eckelman
Publisher: CRC Press
Published: 2017-11-22
Total Pages: 245
ISBN-13: 1351358200
DOWNLOAD EBOOKThis series of books on Radiotracers in Biology and Medicine is on the one hand an unbelievably expansive enterprise and on the other hand, a most noble one as well. Tools to probe biology have developed at an accelerating rate. Hevesy pioneered the application of radioisotopes to the study of chemical processes, and since that time radioisotopic methodology has probably contributed as much as any other methodology to the analysis of the fine structure of biologic systems. Radioisotopic methodologies represent powerful tools for the determination of virtually any process of biologic interest. It should not be surprising, therefore, that any effort to encompass all aspects of radiotracer methodology is both desirable in the extreme and doomed to at least some degree of inherent failure. The current series is assuredly a success relative to the breadth of topics which range from in depth treatise of fundamental science or abstract concepts to detailed and specific applications, such as those medicine or even to the extreme of the methodology for sacrifice of anaimals as part of a radiotracer distribution study.
Author: National Library of Medicine (U.S.)
Publisher:
Published: 1985
Total Pages: 1712
ISBN-13:
DOWNLOAD EBOOKFirst multi-year cumulation covers six years: 1965-70.
Author: National Library of Medicine (U.S.)
Publisher:
Published: 1982
Total Pages: 1184
ISBN-13:
DOWNLOAD EBOOKAuthor: Lelio Colombetti
Publisher: CRC Press
Published: 2020-04-28
Total Pages: 493
ISBN-13: 1000083527
DOWNLOAD EBOOKFirst published in 1982: The book attempts to explain transport processes for radiolabelled tracers.
Author: Richard M. Lambrecht
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 240
ISBN-13: 1461255961
DOWNLOAD EBOOKThe editors have asked me to write this foreword probably for two reasons: First, I have spent 35 years trying to develop radiolabeled compounds that would help diagnose and treat disease. I, and the people from my laboratory, have been much involved with developing Nan'I for the diagnosis and treatment of hyperthyroidism and well-differentiated thyroid cancer. Second, I was a participant throughout the entire symposium upon which this book is based. Our latest '311-labeled compound, [l3lll metaiodobenzylguanidine, took us 13 years to develop. It has succeeded in diagnosing and treating adrenergic tumors '31 under circumstances where Na 1 would have failed for the diagnosis and treatment of thyroid cancer. I therefore hope that more scientists will be attracted to this field. This book is written by intelligent, experienced investigators who are knowl edgeable. It is a must for anyone new in the field. For the experienced, I would like to remind you that I attended the entire symposium; the breadth and timeliness of the update has helped us to redirect some of our current efforts into more scientifically productive channels. William H. Beierwaltes, M.D.
Author: AdrainD. Nunn
Publisher: Routledge
Published: 2018-04-27
Total Pages: 460
ISBN-13: 1351419897
DOWNLOAD EBOOKThis timely resource compares single-photon emission tomography (SPECT), used mainly withTechnetium and iodine for routine clinical examinations, and positron emission tomography(PET) , employing short-lived radionuclides of carbon, oxygen, nitrogen, and fluorine in researchinvestigations.Presenting the logic behind why one approach is better than another in various circumstances,Radio pharmaceuticals details the use of radiolabelled substrates in measuring the effect of diseaseand drugs on regional metabolism and receptor concentration/occupancy .. . discusses factorsaffecting the selective retention of small metal complexes by various tissues .. . analyzes the interactionof small exogenous metal complexes with enzymes in vivo and the critical role of stereochemistry. . . explores the use of radio labelled compounds in the study of neuroactive compounds,neurotransmitters, enzyme inhibitors, and substrates in vivo .. . covers the design and pharmacologyof radiolabelled drugs as probes of site of action , selectivity and specificity, and pharmacokineticsin vivo .. . and more.Extensively referenced with over l 050 bibliographic citations, Radiopharmaceuticals is a state-ofthe-art guide for pharmacists; organic, medicinal , and radiopharmaceutical chemists; pharmacokineticists;nuclear medicine physicians and technologists; neurochemists; and governmentregulatory personnel .
Author:
Publisher:
Published: 1983
Total Pages: 2696
ISBN-13:
DOWNLOAD EBOOKA world list of books in the English language.
Author: Mrinal K. Dewanjee
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 627
ISBN-13: 1461535085
DOWNLOAD EBOOKAmong the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. Biologically important micrmolecules, semimacromolecules, and macromolecules have been identified which, after iodination, almost maintain the same molecular configuration and similar biologic specificity as those of the parent molecules. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. 125r, with a half-life of 60 days, has a crucial role in competitive protein-binding studies. 131r is useful for measuring thyroid uptake, for the diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr , with a reasonably shorter half-life, is almost ideal for thyroid workup and for a few useful labeled radiopharmaceutical. Although ~c is used more widely in diagnostic procedures, the radionuclides of iodine will always have a major role in biology and medicine. A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. The general trend in the use of tracers in clinical nuclear medicine has been an evolution from 3H, 14C, 11C, and 13 to 125 , 131 and 123r to ~c and 111rn.
Author: Alan R. Fritzberg
Publisher: Springer
Published: 1986-02
Total Pages: 184
ISBN-13:
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