"The Oregon Territory, Its History and Discovery" by Travers Twiss is an in-depth exploration of the history and discovery of the Oregon Territory. Twiss delves into the early exploration and settlement of the region, shedding light on the interactions between Native American tribes and European explorers. Through meticulous research and engaging storytelling, this book provides a comprehensive account of the events and individuals that shaped the history of the Oregon Territory. It serves as a valuable resource for historians, researchers, and anyone interested in the rich heritage of this region.
The inimitable style of Hendrik Willem van Loon, the renowned early-20th-century popularizer of all things historical, is at its best in this 1917 book for children. His language is more than merely simple and readable: he brings to life distant times and remote places with an enthusiasm that inspires. The Greeks "lived in a beautiful land of sunshine and temples"; the Norse sailors "dared to leave the sight of land"; Columbus "was no chance explorer who hit upon his discoveries by luck." More than just an account of discovery, it encourages the reader to set out to discover more for himself, too. Fully illustrated with the author's sketches, maps, and color illustrations. ALSO AVAILABLE FROM COSIMO CLASSICS: van Loon's The Fall of the Dutch Republic (1913), The Rise of the Dutch Kingdom (1915), The Golden Book of the Dutch Navigators (1916), and Ancient Man (1920) Dutch-American author, journalist and illustrator HENDRIK WILLEM VAN LOON (1882-1944) was the first winner of the prestigious Newbery Medal for outstanding American children's book for his The Story of Mankind. Acclaimed for his ability to depict history in a lively and entertaining manner for children and adults alike, he was a popular lecturer and radio personality, equally comfortable on informational programs and celebrity quiz shows.
Drug Discovery Stories: From Bench to Bedside presents a collection of cases on the development of highly successful pharmaceuticals. It delves into the realm of drug discovery, exploring the structural biology and biological functions of the sought-after targets. The book covers the identification of promising compounds, their transformation from hits to leads through meticulous optimization, and the elucidation of how key compounds interact with the target (in essence, providing invaluable insights for drug design). Additionally, it covers essential information such as the pivotal biological and PK data of lead compounds, any noteworthy clinical results, and a comprehensive overview of other candidate compounds. The field of drug discovery and development has experienced rapid evolution, with numerous new drugs receiving approval each year. While several books have been published on this subject, there is a pressing need for a new book series that accurately reflects the current advancements in drug discovery. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology. - Analyzes the drug discovery stories of different blockbuster drugs - Includes the newly approved drugs - Covers key aspects related to the drug development of the drugs
"A History of Geographical Discovery in the Seventeenth and Eighteenth Centuries" presents a thorough study of the most important geographical discoveries around the world. The book tells about the expeditions to different parts of the world, from the North Pacific, through Asia, Africa, Americas to Australia.
Science meets real-life mystery in this adventurous look at incredible unexpected finds that changed history. Secret treasures are buried all around us -- you just have to look for them!Accidental Archaeologists takes you on an adventure through time to relive some of the coolest surprise discoveries by totally ordinary people all over the world. Meet:- The cowboy who found an ancient skeleton- A famous king buried underneath a parking lot- The team who found New York City's hidden African Burial Ground- A boy who finds the Dead Sea Scrolls while looking for his lost goat- And many more.Packed with incredible stories and expert tips for making your own exciting finds, this is an accessible, action-packed introduction to the world of archaeology.
CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENT A useful guide for medicinal chemists and pharmaceutical scientists Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners’ knowledge of chemistry and biology, but also—and perhaps more importantly—on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field. Contemporary Accounts in Drug Discovery and Development provides drug discovery scientists with the knowledge they need to quickly gain mastery of the drug discovery process. A thorough accounting is given for each drug covered within the book, as the authors provide pharmacology, drug metabolism, biology, drug development, and clinical studies for every case, with modern drug discovery principles and technologies incorporated throughout. Contemporary Accounts in Drug Discovery and Development readers will also find Case histories used as an engaging way of learning about the drug discovery/development process Detailed biological rational and background information, drug design principles, SAR development, ADMET considerations, and clinical studies The full history of individual marketed small molecule drugs Coverage of drug candidates that have passed Phase I clinical trials with different modalities, such as antibody drug conjugates (ADC), proteolysis-targeting chimera (PROTAC), and peptide drugs The application of new technologies in drug discovery such as DNA-encoded libraries (DEL), positron emission tomography (PET), and physics-based computational modeling employing free energy perturbation (FEP) Contemporary Accounts in Drug Discovery and Development is a helpful tool for medicinal chemists, organic chemists, pharmacologists, and other scientists in drug research and process development. It may be considered essential reading for graduate courses in drug discovery, medicinal chemistry, drug synthesis, pharmaceutical science, and pharmacology. It is also a useful resource for pharmaceutical industry labs, as well as for libraries.
Gomes Eannes de Zurara's 'The History of the Discovery and Conquest of Guinea' is a seminal work that provides a detailed account of the exploration and colonization of West Africa during the 15th century. Written in a straightforward and factual style, the book offers valuable insights into the motives and methods of the Portuguese explorers, as well as the interactions between Europeans and Africans during this period. Zurara's work serves as an important historical document, shedding light on a crucial time in the expansion of European empires and the impact on indigenous populations in Guinea. The narrative is enriched with vivid descriptions of landscapes, encounters, and diplomatic exchanges, making it a fascinating read for those interested in colonial history and cultural exchange in the Age of Exploration. Gomes Eannes de Zurara, a Portuguese chronicler and historian, was appointed by Prince Henry the Navigator to document the achievements of the Portuguese explorers. His firsthand experiences and access to official records allowed him to provide a comprehensive and detailed account of the events in Guinea. As a trusted chronicler of his time, Zurara's work is recognized for its accuracy and attention to detail, adding to its significance as a primary source for historians. 'The History of the Discovery and Conquest of Guinea' is a must-read for anyone interested in the complexities of intercultural relations, colonial expansion, and the lasting impact of European exploration in Africa.
