Functions of survival time; Examples of survival data analysis; Nonparametric methods of estimating survival functions; Nonparametric methods for comparing survival distributions; Some well-known survival distributions and their applications; Graphical methods for sulvival distribution fitting and goodness-of-fit tests; Analytical estimation procedures for sulvival distributions; Parametric methods for comparing two survival distribution; Identification of prognostic factors related to survival time; Identification of risk factors related to dichotomous data; Planning and design of clinical trials (I); Planning and design of clinicL trials(II).
Praise for the Third Edition “. . . an easy-to read introduction to survival analysis which covers the major concepts and techniques of the subject.” —Statistics in Medical Research Updated and expanded to reflect the latest developments, Statistical Methods for Survival Data Analysis, Fourth Edition continues to deliver a comprehensive introduction to the most commonly-used methods for analyzing survival data. Authored by a uniquely well-qualified author team, the Fourth Edition is a critically acclaimed guide to statistical methods with applications in clinical trials, epidemiology, areas of business, and the social sciences. The book features many real-world examples to illustrate applications within these various fields, although special consideration is given to the study of survival data in biomedical sciences. Emphasizing the latest research and providing the most up-to-date information regarding software applications in the field, Statistical Methods for Survival Data Analysis, Fourth Edition also includes: Marginal and random effect models for analyzing correlated censored or uncensored data Multiple types of two-sample and K-sample comparison analysis Updated treatment of parametric methods for regression model fitting with a new focus on accelerated failure time models Expanded coverage of the Cox proportional hazards model Exercises at the end of each chapter to deepen knowledge of the presented material Statistical Methods for Survival Data Analysis is an ideal text for upper-undergraduate and graduate-level courses on survival data analysis. The book is also an excellent resource for biomedical investigators, statisticians, and epidemiologists, as well as researchers in every field in which the analysis of survival data plays a role.
THE MOST PRACTICAL, UP-TO-DATE GUIDE TO MODELLING AND ANALYZING TIME-TO-EVENT DATA—NOW IN A VALUABLE NEW EDITION Since publication of the first edition nearly a decade ago, analyses using time-to-event methods have increase considerably in all areas of scientific inquiry mainly as a result of model-building methods available in modern statistical software packages. However, there has been minimal coverage in the available literature to9 guide researchers, practitioners, and students who wish to apply these methods to health-related areas of study. Applied Survival Analysis, Second Edition provides a comprehensive and up-to-date introduction to regression modeling for time-to-event data in medical, epidemiological, biostatistical, and other health-related research. This book places a unique emphasis on the practical and contemporary applications of regression modeling rather than the mathematical theory. It offers a clear and accessible presentation of modern modeling techniques supplemented with real-world examples and case studies. Key topics covered include: variable selection, identification of the scale of continuous covariates, the role of interactions in the model, assessment of fit and model assumptions, regression diagnostics, recurrent event models, frailty models, additive models, competing risk models, and missing data. Features of the Second Edition include: Expanded coverage of interactions and the covariate-adjusted survival functions The use of the Worchester Heart Attack Study as the main modeling data set for illustrating discussed concepts and techniques New discussion of variable selection with multivariable fractional polynomials Further exploration of time-varying covariates, complex with examples Additional treatment of the exponential, Weibull, and log-logistic parametric regression models Increased emphasis on interpreting and using results as well as utilizing multiple imputation methods to analyze data with missing values New examples and exercises at the end of each chapter Analyses throughout the text are performed using Stata® Version 9, and an accompanying FTP site contains the data sets used in the book. Applied Survival Analysis, Second Edition is an ideal book for graduate-level courses in biostatistics, statistics, and epidemiologic methods. It also serves as a valuable reference for practitioners and researchers in any health-related field or for professionals in insurance and government.
Handbook of Survival Analysis presents modern techniques and research problems in lifetime data analysis. This area of statistics deals with time-to-event data that is complicated by censoring and the dynamic nature of events occurring in time. With chapters written by leading researchers in the field, the handbook focuses on advances in survival analysis techniques, covering classical and Bayesian approaches. It gives a complete overview of the current status of survival analysis and should inspire further research in the field. Accessible to a wide range of readers, the book provides: An introduction to various areas in survival analysis for graduate students and novices A reference to modern investigations into survival analysis for more established researchers A text or supplement for a second or advanced course in survival analysis A useful guide to statistical methods for analyzing survival data experiments for practicing statisticians
Survival analysis deals with the distribution of life times, essentially the times from an initiating event such as birth or the start of a job to some terminal event such as death or pension. This book, originally published in 1980, surveys and analyzes methods that use survival measurements and concepts, and helps readers apply the appropriate method for a given situation. Four broad sections cover introductions to data, univariate survival function, multiple-failure data, and advanced topics.
Praise for the First Edition "An indispensable addition to any serious collection on lifetime data analysis and . . . a valuable contribution to the statistical literature. Highly recommended . . ." -Choice "This is an important book, which will appeal to statisticians working on survival analysis problems." -Biometrics "A thorough, unified treatment of statistical models and methods used in the analysis of lifetime data . . . this is a highly competent and agreeable statistical textbook." -Statistics in Medicine The statistical analysis of lifetime or response time data is a key tool in engineering, medicine, and many other scientific and technological areas. This book provides a unified treatment of the models and statistical methods used to analyze lifetime data. Equally useful as a reference for individuals interested in the analysis of lifetime data and as a text for advanced students, Statistical Models and Methods for Lifetime Data, Second Edition provides broad coverage of the area without concentrating on any single field of application. Extensive illustrations and examples drawn from engineering and the biomedical sciences provide readers with a clear understanding of key concepts. New and expanded coverage in this edition includes: * Observation schemes for lifetime data * Multiple failure modes * Counting process-martingale tools * Both special lifetime data and general optimization software * Mixture models * Treatment of interval-censored and truncated data * Multivariate lifetimes and event history models * Resampling and simulation methodology
This book introduces readers to copula-based statistical methods for analyzing survival data involving dependent censoring. Primarily focusing on likelihood-based methods performed under copula models, it is the first book solely devoted to the problem of dependent censoring. The book demonstrates the advantages of the copula-based methods in the context of medical research, especially with regard to cancer patients’ survival data. Needless to say, the statistical methods presented here can also be applied to many other branches of science, especially in reliability, where survival analysis plays an important role. The book can be used as a textbook for graduate coursework or a short course aimed at (bio-) statisticians. To deepen readers’ understanding of copula-based approaches, the book provides an accessible introduction to basic survival analysis and explains the mathematical foundations of copula-based survival models.
Survival Analysis Using S: Analysis of Time-to-Event Data is designed as a text for a one-semester or one-quarter course in survival analysis for upper-level or graduate students in statistics, biostatistics, and epidemiology. Prerequisites are a standard pre-calculus first course in probability and statistics, and a course in applied linear regression models. No prior knowledge of S or R is assumed. A wide choice of exercises is included, some intended for more advanced students with a first course in mathematical statistics. The authors emphasize parametric log-linear models, while also detailing nonparametric procedures along with model building and data diagnostics. Medical and public health researchers will find the discussion of cut point analysis with bootstrap validation, competing risks and the cumulative incidence estimator, and the analysis of left-truncated and right-censored data invaluable. The bootstrap procedure checks robustness of cut point analysis and determines cut point(s). In a chapter written by Stephen Portnoy, censored regression quantiles - a new nonparametric regression methodology (2003) - is developed to identify important forms of population heterogeneity and to detect departures from traditional Cox models. By generalizing the Kaplan-Meier estimator to regression models for conditional quantiles, this methods provides a valuable complement to traditional Cox proportional hazards approaches.
Quantitative social scientists use survival analysis to understand the forces that determine the duration of events. This Element provides a guideline to new techniques and models in survival analysis, particularly in three areas: non-proportional covariate effects, competing risks, and multi-state models. It also revisits models for repeated events. The Element promotes multi-state models as a unified framework for survival analysis and highlights the role of general transition probabilities as key quantities of interest that complement traditional hazard analysis. These quantities focus on the long term probabilities that units will occupy particular states conditional on their current state, and they are central in the design and implementation of policy interventions.
The first edition of this book (1970) set out a systematic basis for the analysis of binary data and in particular for the study of how the probability of 'success' depends on explanatory variables. The first edition has been widely used and the general level and style have been preserved in the second edition, which contains a substantial amount of new material. This amplifies matters dealt with only cryptically in the first edition and includes many more recent developments. In addition the whole material has been reorganized, in particular to put more emphasis on m.aximum likelihood methods. There are nearly 60 further results and exercises. The main points are illustrated by practical examples, many of them not in the first edition, and some general essential background material is set out in new Appendices.
