Starting with Serotonin
Author: Ann G. Sjoerdsma
Publisher:
Published: 2008
Total Pages: 652
ISBN-13:
DOWNLOAD EBOOKPosts
Serotonin
Author: Michel Houellebecq
Publisher: Farrar, Straus and Giroux
Published: 2019-11-19
Total Pages: 320
ISBN-13: 0374721688
DOWNLOAD EBOOKMichel Houellebecq’s Serotonin is a caustic, frightening, hilarious, raunchy, offensive, and politically incorrect novel about the decline of Europe, Western civilization, and humanity in general. Deeply depressed by his romantic and professional failures, the aging hedonist and agricultural engineer Florent-Claude Labrouste feels he is “dying of sadness.” He hates his young girlfriend, and the feeling is almost certainly mutual; his career is pretty much over; and he has to keep himself thoroughly medicated to cope with day-to-day life. Suffocating in the rampant loneliness, consumerism, hedonism, and sprawl of the city, Labrouste decides to head for the hills, returning to Normandy, where he once worked promoting regional cheeses and where he was once in love, and even—it now seems—happy. There he finds a countryside devastated by globalization and by European agricultural policies, and encounters farmers longing, like Labrouste himself, for an impossible return to a simpler age. As the farmers prepare for what might be an armed insurrection, it becomes clear that the health of one miserable body and of a suffering body politic are not so different, and that all parties may be rushing toward a catastrophe that a whole drugstore’s worth of antidepressants won’t make bearable.
Serotonin
Author: Syd Baumel
Publisher: McGraw Hill Professional
Published: 1999-02
Total Pages: 52
ISBN-13: 9780879838232
DOWNLOAD EBOOKThe neurotransmitter serotonin is the power behind Prozac and the "diet" pill dexfenfluramine. This text presents non-drug serotonin boosters such as vitamins, minerals, herbs and amino acids, and documents their usefulness in many conditions
Fluoxetine
Author: Graziano Pinna
Publisher:
Published: 2015-04-01
Total Pages: 412
ISBN-13: 9781634820769
DOWNLOAD EBOOKFluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.
Histamine in the brain
Author: Jian-Sheng Lin
Publisher: Frontiers Media SA
Published: 2015-03-18
Total Pages: 100
ISBN-13: 2889194345
DOWNLOAD EBOOKBrain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.
The Role of Protein and Amino Acids in Sustaining and Enhancing Performance
Author: Institute of Medicine
Publisher: National Academies Press
Published: 1999-09-15
Total Pages: 448
ISBN-13: 0309172810
DOWNLOAD EBOOKIt is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.
Synthesis of Best-Seller Drugs
Author: Ruben Vardanyan
Publisher: Academic Press
Published: 2016-01-07
Total Pages: 870
ISBN-13: 0124115241
DOWNLOAD EBOOKSynthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation
Depression and Heart Disease
Author: Alexander Glassman
Publisher: John Wiley & Sons
Published: 2011-06-20
Total Pages: 110
ISBN-13: 1119957621
DOWNLOAD EBOOKRecently, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. Patients with psychiatric problems, particularly depression, may be more susceptible to cardiovascular disorders. Depression and Heart Disease synthesizes current evidence, including some previously unpublished data, in a concise, easy-to-read format. The authors succinctly describe the epidemiology, pathogenesis (including cytokines and genetics), and risk factors of the comorbidity between depression and heart disease. The book also reviews the best pharmacological and psychotherapeutic approaches for people with this comorbidity.
Drug-Induced Liver Injury
Author:
Publisher: Academic Press
Published: 2019-07-13
Total Pages: 290
ISBN-13: 0128173173
DOWNLOAD EBOOKDrug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
Habits of a Happy Brain
Author: Loretta Graziano Breuning
Publisher: Simon and Schuster
Published: 2015-12-16
Total Pages: 240
ISBN-13: 1440590508
DOWNLOAD EBOOKOffers simple activities that help you understand the roles of your "happy chemicals"--serotonin, dopamine, oxytocin, and endorphins. You'll also learn how to build new habits by rerouting the electricity in your brain to flow down a new pathway, making it even easier to trigger these happy chemicals and increase feelings of satisfaction when you need them most.
