When J. H. Elliott published Spain and Its World, 1500?1700 some twenty years ago, one of many enthusiasts declared, ?For anyone interested in the history of empire, of Europe and of Spain, here is a book to keep within reach, to read, to study and to enjoy" (Times Literary Supplement). Since then Elliott has continued to explore the history of Spain and the Hispanic world with originality and insight, producing some of the most influential work in the field. In this new volume he gathers writings that reflect his recent research and thinking on politics, art, culture, and ideas in Europe and the colonial worlds between 1500 and 1800.The volume includes fourteen essays, lectures, and articles of remarkable breadth and freshness, written with Elliott's characteristic brio. It includes an unpublished lecture in honor of the late Hugh Trevor-Roper. Organized around three themes?early modern Europe, European overseas expansion, and the works and historical context of El Greco, Velzquez, Rubens, and Van Dyck?the book offers a rich survey of the themes at the heart of Elliott's interests throughout a career distinguished by excellence and innovation.
Fifteenth-century Spain is a richly multicultural society in which Jews, Muslims, and Christians coexist. But under the zealous Christian Queen Isabella, the country abruptly becomes one of the most murderously intolerant places on Earth. It is in this atmosphere that the Benvenistes, a family of scribes, attempt to eke out a living. The family has a secret—they are conversos: Jews who converted to Christianity. Now, with neighbors and friends turned into spies, fear hangs in the air. One day a young man is delivered to their door. His name is Amir, and he wears the robe and red patch of a Muslim. Fifteen-year-old Ramon Benveniste broods over Amir’s easy acceptance into the family. Startling and dramatic events overtake the household, and the family is torn apart. One boy becomes enslaved, the other takes up service for the Inquisitors. Finally, their paths cross again in a stunningly haunting scene.
Finally, Grieve focuses on the misogynistic elements of the story and asks why the fall of Spain is figured as a cautionary tale about a woman's sexuality.
The Annual Asian Semantic Web Conference is one of the largest regional events in Asia with focused topics related to the Semantic Web. With the decade-round endeavor of Semantic Web believers, researchers and practitioners, the Semantic Web has made remarkable progress recently. It has raised significant attention from US and UK governments, as well as the European Commission who are willing to deploy Semantic Web technologies to enhance the transparency of eGovernment. The Linked Open Data initiative is on its way to convert the current document Web into a data Web and to further enabling various data and service mashups. The fast adoption of Semantic Web technologies in medical and life sciences has created impressive showcases to the world. All these efforts are a crucial step toward enabling the take-off and the success of the Semantic Web. The First Asian Semantic Web Conference was successfully held in China in 2006. With the following editions in Korea in 2007 and Thailand in 2008, it fostered a regional forum for connecting researchers and triggering innovations. This year, the 4th Asian Semantic Web Conference was held in Shanghai, China. We received 63 submissions from Asia, Europe, and North America, and 25 papers were accepted (the acceptance rate is around 40%). Each submission was reviewed by at least three members of the Program Committee. The Chairs moderated the discussion of conflict reviews or invited external reviewers to reach the final decisions.
Brookings Papers on Economic Activity (BPEA) provides academic and business economists, government officials, and members of the financial and business communities with timely research on current economic issues. Contents: On Secular Stagnation in the Industrialized World, Lukasz Rachel and Lawrence H. Summers A Forensic Examination of China's National Accounts, Wei Chen, Xilu Chen, Chang-Tai Hsieh, and Zheng Song A Unified Approach to Measuring u*, Richard K. Crump, Stefano Eusepi, Maric Giannoni, and Ays ̧egül S ̧ahin Fiscal Space and the Aftermath of Financial Crises: How It Matters and Why, Christina D. Romer and David H. Romer Okun Revisited: Who Benefits Most from a Strong Economy? Stephanies R. Aaronson, Mary C. Daly, William L. Wascher, and David W. Wilcox On the Economics of a Carbon Tax for the United States, Gilbert E. Metcalf
The PISA 2009 Technical Report describes the methodology underlying the PISA 2009 survey. It examines additional features related to the implementation of the project at a level of detail that allows researchers to understand and replicate its analysis.
“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.
The discovery of the New World raised many questions for early modern scientists: What did these lands contain? Where did they lie in relation to Europe? Who lived there, and what were their inhabitants like? Imperial expansion necessitated changes in the way scientific knowledge was gathered, and Spanish cosmographers in particular were charged with turning their observations of the New World into a body of knowledge that could be used for governing the largest empire the world had ever known. As María M. Portuondo here shows, this cosmographic knowledge had considerable strategic, defensive, and monetary value that royal scientists were charged with safeguarding from foreign and internal enemies. Cosmography was thus a secret science, but despite the limited dissemination of this body of knowledge, royal cosmographers applied alternative epistemologies and new methodologies that changed the discipline, and, in the process, how Europeans understood the natural world.
Examining major terrorist acts and campaigns undertaken in the decade following September 11, 2001, internationally recognized scholars study the involvement of global terrorist leaders and organizations in these incidents and the planning, organization, execution, recruitment, and training that went into them. Their work captures the changing character of al-Qaeda and its affiliates since the invasions of Afghanistan and Iraq and the sophisticated elements that, despite the West's best counterterrorism efforts, continue to exert substantial direction over jihadist terrorist operations. Through case studies of terrorist acts and offensives occurring both in and outside the West, the volume's contributors investigate al-Qaeda and other related entities as they adapted to the strategies of Operation Enduring Freedom and subsequent U.S.-led global counterterrorism programs. They explore whether Osama bin Laden was indeed reduced to a mere figurehead before his death or continued to influence al-Qaeda's global activities. Did al-Qaeda become a loose collection of individuals and ideas following its expulsion from Afghanistan, or was it reborn as a transnational terrorist structure powered by a well-articulated ideology? What is the preeminent terrorist threat we face today, and what will it look like in the future? This anthology pinpoints the critical patterns and strategies that will inform counterterrorism in the coming decades.
From the precocious charms of Shirley Temple to the box-office behemoth Frozen and its two young female leads, Anna and Elsa, the girl has long been a figure of fascination for cinema. The symbol of (imagined) childhood innocence, the site of intrigue and nostalgia for adults, a metaphor for the precarious nature of subjectivity itself, the girl is caught between infancy and adulthood, between objectification and power. She speaks to many strands of interest for film studies: feminist questions of cinematic representation of female subjects; historical accounts of shifting images of girls and childhood in the cinema; and philosophical engagements with the possibilities for the subject in film. This collection considers the specificity of girls' experiences and their cinematic articulation through a multicultural feminist lens which cuts across the divides of popular/art-house, Western/non Western, and north/south. Drawing on examples from North and South America, Asia, Africa, and Europe, the contributors bring a new understanding of the global/local nature of girlhood and its relation to contemporary phenomena such as post-feminism, neoliberalism and queer subcultures. Containing work by established and emerging scholars, this volume explodes the narrow post-feminist canon and expands existing geographical, ethnic, and historical accounts of cinematic cultures and girlhood.
