Some Current Mathematical Topics in Cancer Research
Author: George W. Swan
Publisher:
Published: 1977
Total Pages: 326
ISBN-13:
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Introduction to Mathematical Oncology
Author: Yang Kuang
Publisher: CRC Press
Published: 2016-04-05
Total Pages: 469
ISBN-13: 1584889918
DOWNLOAD EBOOKIntroduction to Mathematical Oncology presents biologically well-motivated and mathematically tractable models that facilitate both a deep understanding of cancer biology and better cancer treatment designs. It covers the medical and biological background of the diseases, modeling issues, and existing methods and their limitations. The authors introduce mathematical and programming tools, along with analytical and numerical studies of the models. They also develop new mathematical tools and look to future improvements on dynamical models. After introducing the general theory of medicine and exploring how mathematics can be essential in its understanding, the text describes well-known, practical, and insightful mathematical models of avascular tumor growth and mathematically tractable treatment models based on ordinary differential equations. It continues the topic of avascular tumor growth in the context of partial differential equation models by incorporating the spatial structure and physiological structure, such as cell size. The book then focuses on the recent active multi-scale modeling efforts on prostate cancer growth and treatment dynamics. It also examines more mechanistically formulated models, including cell quota-based population growth models, with applications to real tumors and validation using clinical data. The remainder of the text presents abundant additional historical, biological, and medical background materials for advanced and specific treatment modeling efforts. Extensively classroom-tested in undergraduate and graduate courses, this self-contained book allows instructors to emphasize specific topics relevant to clinical cancer biology and treatment. It can be used in a variety of ways, including a single-semester undergraduate course, a more ambitious graduate course, or a full-year sequence on mathematical oncology.
Current Catalog
Author: National Library of Medicine (U.S.)
Publisher:
Published:
Total Pages: 1728
ISBN-13:
DOWNLOAD EBOOKFirst multi-year cumulation covers six years: 1965-70.
Mathematical Models in Cancer Research,
Author: T. E. Wheldon
Publisher: CRC Press
Published: 1988
Total Pages: 272
ISBN-13:
DOWNLOAD EBOOKCancer research deals with all aspects of malignant transformation, tumour growth and the effects of treatment. Mathematical models enable quantitative representations of the changes affecting cell state and cell number. This book provides a review of the scope of mathematical modelling in cancer research, bringing together for the first time a group of related mathematical topics including multistage carcinogenesis, tumour growth kinetics, growth control, radiotherapy, chemotherapy and biological targeting in cancer treatment. Physicists and mathematicians interested in medical research, biomathematicians, biostatisticians, radiation and medical oncologists and experimental and theoretical biologists will welcome this critical review of mathematical modelling in cancer research. This book will also be of interest to clinicians, basic cancer scientists and physicists working in radiotherapy departments, and to postgraduate students on courses in oncology and subjects.
Dynamics Of Cancer: Mathematical Foundations Of Oncology
Author: Dominik Wodarz
Publisher: World Scientific
Published: 2014-04-24
Total Pages: 533
ISBN-13: 9814566381
DOWNLOAD EBOOKThe book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells.
Mathematical Oncology 2013
Author: Alberto d'Onofrio
Publisher: Springer
Published: 2014-10-16
Total Pages: 336
ISBN-13: 1493904582
DOWNLOAD EBOOKWith chapters on free boundaries, constitutive equations, stochastic dynamics, nonlinear diffusion–consumption, structured populations, and applications of optimal control theory, this volume presents the most significant recent results in the field of mathematical oncology. It highlights the work of world-class research teams, and explores how different researchers approach the same problem in various ways. Tumors are complex entities that present numerous challenges to the mathematical modeler. First and foremost, they grow. Thus their spatial mean field description involves a free boundary problem. Second, their interiors should be modeled as nontrivial porous media using constitutive equations. Third, at the end of anti-cancer therapy, a small number of malignant cells remain, making the post-treatment dynamics inherently stochastic. Fourth, the growth parameters of macroscopic tumors are non-constant, as are the parameters of anti-tumor therapies. Changes in these parameters may induce phenomena that are mathematically equivalent to phase transitions. Fifth, tumor vascular growth is random and self-similar. Finally, the drugs used in chemotherapy diffuse and are taken up by the cells in nonlinear ways. Mathematical Oncology 2013 will appeal to graduate students and researchers in biomathematics, computational and theoretical biology, biophysics, and bioengineering.
Dynamical Systems
Author: D. Arrowsmith
Publisher: CRC Press
Published: 1992-08-01
Total Pages: 344
ISBN-13: 9780412390807
DOWNLOAD EBOOKThis text discusses the qualitative properties of dynamical systems including both differential equations and maps. The approach taken relies heavily on examples (supported by extensive exercises, hints to solutions and diagrams) to develop the material, including a treatment of chaotic behavior. The unprecedented popular interest shown in recent years in the chaotic behavior of discrete dynamic systems including such topics as chaos and fractals has had its impact on the undergraduate and graduate curriculum. However there has, until now, been no text which sets out this developing area of mathematics within the context of standard teaching of ordinary differential equations. Applications in physics, engineering, and geology are considered and introductions to fractal imaging and cellular automata are given.
Dynamical Systems
Author: C.M. Place
Publisher: Taylor & Francis
Published: 2017-11-22
Total Pages: 341
ISBN-13: 1351454285
DOWNLOAD EBOOKThis text discusses the qualitative properties of dynamical systems including both differential equations and maps. The approach taken relies heavily on examples (supported by extensive exercises, hints to solutions and diagrams) to develop the material, including a treatment of chaotic behavior. The unprecedented popular interest shown in recent years in the chaotic behavior of discrete dynamic systems including such topics as chaos and fractals has had its impact on the undergraduate and graduate curriculum. However there has, until now, been no text which sets out this developing area of mathematics within the context of standard teaching of ordinary differential equations. Applications in physics, engineering, and geology are considered and introductions to fractal imaging and cellular automata are given.
A Survey of Models for Tumor-Immune System Dynamics
Author: John A. Adam
Publisher: Springer Science & Business Media
Published: 2012-10-06
Total Pages: 357
ISBN-13: 0817681191
DOWNLOAD EBOOKMathematical Modeling and Immunology An enormous amount of human effort and economic resources has been directed in this century to the fight against cancer. The purpose, of course, has been to find strategies to overcome this hard, challenging and seemingly endless struggle. We can readily imagine that even greater efforts will be required in the next century. The hope is that ultimately humanity will be successful; success will have been achieved when it is possible to activate and control the immune system in its competition against neoplastic cells. Dealing with the above-mentioned problem requires the fullest pos sible cooperation among scientists working in different fields: biology, im munology, medicine, physics and, we believe, mathematics. Certainly, bi ologists and immunologists will make the greatest contribution to the re search. However, it is now increasingly recognized that mathematics and computer science may well able to make major contributions to such prob lems. We cannot expect mathematicians alone to solve fundamental prob lems in immunology and (in particular) cancer research, but valuable sup port, however modest, can be provided by mathematicians to the research aspirations of biologists and immunologists working in this field.
Optimization of Human Cancer Radiotherapy
Author: G.W. Swan
Publisher: Springer Science & Business Media
Published: 2013-03-08
Total Pages: 293
ISBN-13: 3642464416
DOWNLOAD EBOOKThe mathematical models in this book are concerned with a variety of approaches to the manner in which the clinical radiologic treatment of human neoplasms can be improved. These improvements comprise ways of delivering radiation to the malignan cies so as to create considerable damage to tumor cells while sparing neighboring normal tissues. There is no unique way of dealing with these improvements. Accord ingly, in this book a number of different presentations are given. Each presentation has as its goal some aspect of the improvement, or optimization, of radiotherapy. This book is a collection of current ideas concerned with the optimization of human cancer radiotherapy. It is hoped that readers will build on this collection and develop superior approaches for the understanding of the ways to improve therapy. The author owes a special debt of thanks to Kathy Prindle who breezed through the typing of this book with considerable dexterity. TABLE OF CONTENTS Chapter GENERAL INTRODUCTION 1. 1 Introduction 1 1. 2 History of Cancer and its Treatment by Radiotherapy 8 1. 3 Some Mathematical Models of Tumor Growth 12 1. 4 Spatial Distribution of the Radiation Dose 20 Chapter 2 SURVIVAL CURVES FROM STATISTICAL MODELS 24 2. 1 Introduction 24 2. 2 The Target Model 26 2. 3 Single-hit-to-kill Model 27 2. 4 Multitarget, Single-hit Survival 29 2. 5 Multitarget, Multihit Survival 31 2. 6 Single-target, Multihit Survival 31 2.
