Photoionization and Photo-Induced Processes in Mass Spectrometry
Photoionization and Photo-Induced Processes in Mass Spectrometry

Author: Ralf Zimmermann

Publisher: John Wiley & Sons

Published: 2021-07-06

Total Pages: 448

ISBN-13: 3527335102

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Provides comprehensive coverage of laser-induced ionization processes for mass spectrometry analysis Drawing on the expertise of the leading academic and industrial research groups involved in the development of photoionization methods for mass spectrometry, this reference for analytical scientists covers both the theory and current applications of photo-induced ionization processes. It places widely used techniques such as MALDI side by side with more specialist approaches such as REMPI and RIMS, and discusses leading edge developments in ultrashort laser pulse desorption, to give readers a complete picture of the state of the technology. Photoionization and Photo-Induced Processes in Mass Spectrometry: Fundamentals and Applications starts with a complete overview of the fundamentals of the technique, covering the basics of the gas phase ionization as well as those of laser desorption and ablation, pulse photoionization, and single particle ionization. Numerous application examples from different analytical fields are described that showcase the power and the wide scope of photo ionization in mass spectrometry. -The first general reference book on photoionization techniques for mass spectrometry -Examines technologies and applications of gas phase resonance-enhanced multiphoton ionization mass spectrometry (REMPI-MS) and gas phase resonance ionization mass spectrometry (RIMS) -Provides complete coverage of popular techniques like MALDI -Discusses the current and potential applications of each technology, focusing on process and environmental analysis Photoionization and Photo-Induced Processes in Mass Spectrometry: Fundamentals and Applications is an excellent book for spectroscopists, analytical chemists, photochemists, physical chemists, and laser specialists.

Biophysical Characterization of Proteins in Developing Biopharmaceuticals
Biophysical Characterization of Proteins in Developing Biopharmaceuticals

Author: Damian J. Houde

Publisher: Elsevier

Published: 2019-11-13

Total Pages: 588

ISBN-13: 0444641742

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Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today's industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals. In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical's developability and the technical decision-making process needed when dealing with biophysical characterization data. - Presents basic protein characterization methods and tools applicable to (bio)pharmaceutical research and development - Highlights the capabilities and limitations of each technique - Discusses the underlining science of each tool - Empowers industrial biophysical chemists by providing a roadmap for applying biophysical tools - Outlines the needs for new characterization and analytical tools in the biopharmaceutical industry

Analysis and Characterisation of Metal-Based Nanomaterials
Analysis and Characterisation of Metal-Based Nanomaterials

Author: Radmila Milacic

Publisher: Elsevier

Published: 2021-06-03

Total Pages: 452

ISBN-13: 0323853056

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Analysis and Characterisation of Metal-Based Nanomaterials, Volume 93 in the Comprehensive Analytical Chemistry series, introduces recent developments in analytical methodologies for detection, characterization and quantification of metal-based nanomaterials and their applications to a variety of complex environmental, biological and food samples as well as different consumer products. Single-particle inductively coupled plasma mass spectrometry is highlighted as a powerful analytical tool for number-based concentration and size distribution, also from the metrological viewpoint. An emerging approach for the measurement of multi-metal nanoparticles by single-particle inductively coupled plasma time-of-flight mass spectrometry is discussed. Imaging of metal-based nanoparticles by hyphenated inductively coupled plasma-based techniques is also introduced. The potential of different liquid chromatography and field flow fractionation separation techniques hyphenated to inductively coupled plasma mass spectrometry is emphasized as a powerful tool in particular for complex matrices and small particles sizes. The use of different microscopic techniques for the characterization of metal-based nanoparticles and characterization of metal-based nanoparticles as contrast agents for magnetic resonance imaging are presented. Moreover, occurrence, behaviour and fate of inorganic nanoparticles in the environment is overviewed. Finally, the need for quality control standards and reference nano-materials is emphasized throughout. Presents recent developments in analytical methodologies based on mass spectrometry, light scattering and microscopic techniques for detection, characterization and quantification of metal-based nanomaterials Describes applications of the nanoparticle analysis in a variety of complex environmental, biological and food samples as well as different consumer products Provides the metrological aspects for the analysis of metal-based nanoparticles when using emerging techniques such as single-particle inductively coupled plasma mass spectrometry

Microbial Nanobionics
Microbial Nanobionics

Author: Ram Prasad

Publisher: Springer

Published: 2019-06-18

Total Pages: 296

ISBN-13: 3030165345

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Microbial Nanobionics: Volume 2, Basic Research Applications continues the important discussion of microbial nanoparticle synthesis with a focus on the mechanistic approach of biosynthesis towards nanobionics. This volume also explores the toxicity of nanomaterials in microbes and their effect on human health and the environment. Special Emphasis is given to the use of polymeric nanomaterials in smart packing for the food industry and agricultural sector. The future of nanomaterials for detection of soil microbes and their interactions and tools for environmental remedies is also comprehensively covered. The rich biodiversity of microbes make them excellent candidates for potential nanoparticle synthesis biofactories. Through a better understanding of the biochemical and molecular mechanisms of the microbial biosynthesis of metal nanoparticles, the rate of synthesis can be better developed and the monodispersity of the product can be enhanced. The characteristics of nanoparticles can be controlled via optimization of important parameters, such as temperature, pH, concentration and pressure, which regulate microbe growth conditions and cellular and enzymatic activities. Large scale microbial synthesis of nanoparticles is a sustainable method due to the non-hazardous, non-toxic and economical nature of these processes. The applications of microbial synthesis of nanoparticles are wide and varied, spanning the industrial, biomedical and environmental fields. Biomedical applications include improved and more targeted antimicrobials, biosensing, imaging and drug delivery. In the environmental fields, nanoparticles are used for bioremediation of diverse contaminants, water treatment, catalysis and production of clean energy. With the expected growth of microbial nanotechnology, this volume will serve as a comprehensive and timely reference.

Urban Aerosols and Their Impacts
Urban Aerosols and Their Impacts

Author: Jeffrey S. Gaffney

Publisher:

Published: 2006

Total Pages: 392

ISBN-13:

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Urban aerosols have been identified as important species of concern due to their potential health and environmental impacts. This symposium series book will describe the basic chemistry and physics determining the impacts of aerosol species and will highlight the research results from the measurements that were taken following the collapse of the World Trade Center (WTC) on 9/11/01. The WTC tragedy led to the release of millions of pounds of debris aside from the structural steel, part of which was widely dissipated as aerosols and particulates in the debris cloud over lower Manhattan. Additionally, continuing fires under the debris led to the release of fine combustion related aerosols for a considerable time period in this urban environment. Held during the week of the second anniversary of the WTC tragedy in NYC, the symposium book will describe various aspects of the event, aerosol and gas exposures, and the related impacts of these aerosols. The book contributions will highlight efforts work from atmospheric chemists, meteorologists, health workers, and biologists for a timely compilation of what is known and not known about the composition and transport of tropospheric aerosols in urban environs, particularly those from the WTC collapse. Particular interest is in the acute and chronic environmental effects of these aerosols as they impact human health. Chapters included in the book will also address aerosol lifetimes, aerosol transport and removal processes, acute and chronic health effects to fine aerosol and particulate exposures, and the environmental impacts of aerosols.

Introduction to Mass Spectrometry
Introduction to Mass Spectrometry

Author: J. Throck Watson

Publisher: John Wiley & Sons

Published: 2013-07-09

Total Pages: 972

ISBN-13: 1118681584

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Completely revised and updated, this text provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations. Written by internationally recognised experts and utilising "real life" examples of analyses and applications, the book presents real cases of qualitative and quantitative applications of mass spectrometry. Unlike other mass spectrometry texts, this comprehensive reference provides systematic descriptions of the various types of mass analysers and ionisation, along with corresponding strategies for interpretation of data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry

Mass Spectrometry in Polymer Chemistry
Mass Spectrometry in Polymer Chemistry

Author: Christopher Barner-Kowollik

Publisher: John Wiley & Sons

Published: 2012-01-27

Total Pages: 501

ISBN-13: 3527641831

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Combining an up-to-date insight into mass-spectrometric polymer analysis beyond MALDI with application details of the instrumentation, this is a balanced and thorough presentation of the most important and widely used mass-spectrometric methods. Written by the world's most proficient experts in the field, the book focuses on the latest developments, covering such technologies and applications as ionization protocols, tandem and liquid chromatography mass spectrometry, gas-phase ion-separation techniques and automated data processing. Chapters on sample preparation, polymer degradation and the usage of mass-spectrometric tools on an industrial scale round off the book. As a result, both entrants to the field and experienced researchers are able to choose the appropriate methods and instrumentations -- and to assess their respective strengths and limitations -- for the characterization of polymer compounds.

Essentials of Pharmaceutical Analysis
Essentials of Pharmaceutical Analysis

Author: Muhammad Sajid Hamid Akash

Publisher: Springer Nature

Published: 2019-12-17

Total Pages: 235

ISBN-13: 9811515476

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Recent advances in the pharmaceutical sciences and biotechnology have facilitated the production, design, formulation and use of various types of pharmaceuticals and biopharmaceuticals. This book provides detailed information on the background, basic principles, and components of techniques used for the analysis of pharmaceuticals and biopharmaceuticals. Focusing on those analytical techniques that are most frequently used for pharmaceuticals, it classifies them into three major sections and 19 chapters, each of which discusses a respective technique in detail. Chiefly intended for graduate students in the pharmaceutical sciences, the book will familiarize them with the components, working principles and practical applications of these indispensable analytical techniques.

Microphysics of Clouds and Precipitation
Microphysics of Clouds and Precipitation

Author: H.R. Pruppacher

Publisher: Springer Science & Business Media

Published: 2010-06-25

Total Pages: 975

ISBN-13: 0306481006

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Cloud physics has achieved such a voluminous literature over the past few decades that a significant quantitative study of the entire field would prove unwieldy. This book concentrates on one major aspect: cloud microphysics, which involves the processes that lead to the formation of individual cloud and precipitation particles. Common practice has shown that one may distinguish among the following addi tional major aspects: cloud dynamics, which is concerned with the physics respon sible for the macroscopic features of clouds; cloud electricity, which deals with the electrical structure of clouds and the electrification processes of cloud and precipi tation particles; and cloud optics and radar meteorology, which describe the effects of electromagnetic waves interacting with clouds and precipitation. Another field intimately related to cloud physics is atmospheric chemistry, which involves the chemical composition ofthe atmosphere and the life cycle and characteristics of its gaseous and particulate constituents. In view of the natural interdependence of the various aspects of cloud physics, the subject of microphysics cannot be discussed very meaningfully out of context. Therefore, we have found it necessary to touch briefly upon a few simple and basic concepts of cloud dynamics and thermodynamics, and to provide an account of the major characteristics of atmospheric aerosol particles. We have also included a separate chapter on some of the effects of electric fields and charges on the precipitation-forming processes.