Silk proteins show excellent biocompatibility, controllable biodegradability and non-immunogenicity, and as such are studied extensively worldwide for biomedical applications. In particular, there is increasing interest in their use for drug delivery systems. This focussed book on silk proteins for drug delivery systems, delves into a key emerging area to outline the concepts and define the field. Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin. Showing how these proteins are employed in micro and nano drug delivery systems, their use in pre-clinical and clinical trials, and closing with chapter on sustainability- driven innovation in the pharma industry, this book is ideal for graduates and researchers in biomaterials science and pharmaceutical science.
Over the past few decades, there has been unprecedented progress in the design of versatile biopolymer-based nanoplatforms for pharmaceutical and biomedical applications, particularly due to their attractive traits, including excellent biocompatibility, outstanding biodegradability, low immunogenicity, and facile chemical modifiability. Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications serves as a clear and detailed body of information on the synthesis and characterization of biopolymer-based materials in nanomedicine. This book describes various nanomaterials consisting of biopolymers including polysaccharides (i.e., derived from plants, animals, bacteria, algae, and fungi) and polypeptides in terms of their structures, synthetic protocols, and characterization and uses as therapeutic drugs and gene delivery carriers and in other biomedical fields. The chapters of this book, which are contributed by internationally renowned scholars working in the arena of biopolymer-based nanomaterials, would offer a wide vision on the potential future applications of these nanomaterials in the delivery and targeting of bioactive molecules of pharmaceutical interests and in tissue engineering, biosensing, bioimaging, and diagnostic purposes. The state-of-the-art information presented in the book would also encourage young investigators and researchers to further bring cutting-edge developments in the field of nanomedicine in the near future. Provides a scholarly insight into the recent development of biopolymer-based nanomaterials Focuses on the diverse cutting-edge techniques for the fabrication of native and modified biopolymer-based nanoplatforms and their applications in drug delivery and biomedical fields Assesses the opportunities and challenges of biopolymer-based nanocarriers in pharmaceutical and biomedical research
The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.
Conventional materials technology has yielded clear improvements in regenerative medicine. Ideally, however, a replacement material should mimic the living tissue mechanically, chemically, biologically and functionally. The use of tissue-engineered products based on novel biodegradable polymeric systems will lead to dramatic improvements in health
Silk is increasingly being used as a biomaterial for tissue engineering applications, as well as sutures, due to its unique mechanical and chemical properties. Silk Biomaterials for Tissue Engineering and Regenerative Medicine discusses the properties of silk that make it useful for medical purposes and its applications in this area. Part one introduces silk biomaterials, discussing their fundamentals and how they are processed, and considering different types of silk biomaterials. Part two focuses on the properties and behavior of silk biomaterials and the implications of this for their applications in biomedicine. These chapters focus on topics including biodegradation, bio-response to silk sericin, and capillary growth behavior in porous silk films. Finally, part three discusses the applications of silk biomaterials for tissue engineering, regenerative medicine, and biomedicine, with chapters on the use of silk biomaterials for vertebral, dental, dermal, and cardiac tissue engineering. Silk Biomaterials for Tissue Engineering and Regenerative Medicine is an important resource for materials and tissue engineering scientists, R&D departments in industry and academia, and academics with an interest in the fields of biomaterials and tissue engineering. Discusses the properties and applications of silk for medical purposes Considers pharmaceutical and cosmeceutical applications
Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications
Silk from Bombyx mori is being used in humans for loading applications due to its excellent mechanical properties and biocompatibility. Furthermore silk is emerging as potential biomaterial for biomedical applications such as drug delivery and tissue-engineering. The aim of this thesis was to examine the potential of silk nanoparticles for drug delivery by characterizing (1) particle size, (2) zeta potential, (3) stability, (4) loading efficiency and (5) in vitro drug release. First, silk nanoparticles were generated by a desolvation method using acetone. The resulting particle size and zeta potential were measured using dynamic light scattering, which revealed nano-sized particles (104.20 ± 1.70 nm) with narrow polydispersity index (0.11 ± 0.01), and negative surface charge (-56.38 ± 5.60 mV). In water silk nanoparticles were stable over 4 weeks over wide temperature range (4°C to 37°C). Second, nanoparticles were surface modified with polyethylene glycol (PEG) by reacting cyanuric chloride activated methoxypolyethylene glycol (5000 g/mol) with silk. The amount of activated PEG grafted to particle's surface was controlled by the weight ratio to silk nanoparticles, resulting in 19.39 ± 1.93% w/w conjugated PEG. The stability of PEGylated silk nanoparticles in water and in phosphate buffered saline at pH 7.4 was studied and compared with unmodified silk nanoparticles; PEGylated silk nanoparticles had a superior stability over the unmodified nanoparticles in phosphate buffered saline. Third, the drug loading and release behavior of silk nanoparticles and PEGylated silk nanoparticles was investigated with two model drugs; propranolol HCl and doxorubicin HCl. The native and PEGylated silk nanoparticles showed high encapsulation efficiency for doxorubicin HCl (100% w/w) and propranolol HCl (> 93% w/w). The release of doxorubicin HCl over 14 days was pH dependent, and showed highest release at pH 4.5 from native and PEGylated silk nanoparticles as compared to pH 6.0 and 7.4 (pH 4.5”6.0>7.4). PEGylation significantly impacted on the release behavior of doxorubicin HCl from silk nanoparticles by showing faster release at pH 4.5 and 6.0 in comparison to unmodified silk nanoparticles. In conclusion, silk nanoparticles and PEGylated silk nanoparticles showed promise as potential anticancer drug delivery systems and warrant future in vitro studies.
