Selective Heat Sensitivity of Cancer Cells
Selective Heat Sensitivity of Cancer Cells

Author: A. Rossi-Fanelli

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 334

ISBN-13: 3642810802

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Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism. In 1963-1964, this problem was again attacked by us both from the biochemical and from the clinical points of view. The first results of this joint effort were positive beyond expectation, and generated a new revial of studies aimed at the identification of the nature of the bio chemical lesion as well as at the optimization of technique and of the therapeutic schedules connected with clinical use. Although the number of mammalian tumors which have been proved to be heat-sensitive is now relatively large, and although in some cases a correlation has been demonstrated between tumorigenicity and heat-sensitivity of in vitro cultured cell lines, the question of a direct and constant relationship between neoplastic character and higher sensitivity to hyperthermic exposure is still open to continuing investigation and reappraisal. Several studies deal in fact with the determination of the conditions under which, in vitro and or in vivo, different tumors are efficiently damaged by elevated temperatures.

Hyperthermia In Cancer Treatment: A Primer
Hyperthermia In Cancer Treatment: A Primer

Author: Gian F. Baronzio

Publisher: Springer Science & Business Media

Published: 2008-05-08

Total Pages: 382

ISBN-13: 0387334416

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Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.

Heat Shock Proteins in Cancer
Heat Shock Proteins in Cancer

Author: Stuart K. Calderwood

Publisher: Springer Science & Business Media

Published: 2007-09-09

Total Pages: 399

ISBN-13: 1402064012

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Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

HSF1 and Molecular Chaperones in Biology and Cancer
HSF1 and Molecular Chaperones in Biology and Cancer

Author: Marc Laurence Mendillo

Publisher: Springer Nature

Published: 2020-04-15

Total Pages: 185

ISBN-13: 3030402045

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Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Biological Basis of Oncologic Thermotherapy
Biological Basis of Oncologic Thermotherapy

Author: Michel Gautherie

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 466

ISBN-13: 3642749399

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Studies on the effects of hyperthermia have aroused great interest in recent years. On the one hand, it has been demonstrated. that hyperthermia may be a useful treatment modality for tumors, in combination with ionizing radia tion or cytotoxic drugs. On the other hand, it is of great scientific interest to study the effects of increased temperature on biological systems. Although hyperthermia has been used in the treatment of cancer for cen turies, its therapeutic success was doubtful. However, since it has been shown that radiation-induced cell killirtg can be remarkably enhanced by hyperthermia, many investigations have been performed with cells in vitro, tumors in situ, and normal tissues. From these studies it has been concluded that many biological phenomena and their characteristics which are found in tumors may be conducive to the use of hyperthermia in cancer therapy. Many researchers are studying the cell-killing mechanisms of heat and fac tors that modify cell thermosensitivity. A very fascinating biological phenomenon is the general observation that living cells can enhance their thermoresistance within hours of heat treatment. The development of such thermotolerance is apparently a universal process, and its mechanism is of general scientific interest. Metabolic and physiological processes are changed during and after hyperthermic treatment. These changes exert a strong feedback on the thermo sensitivity of cells and tissues, and also in fluence the heating characteristics of tissues, especially in tumors.

Thermoradiotherapy and Thermochemotherapy
Thermoradiotherapy and Thermochemotherapy

Author: M.Heinrich Seegenschmiedt

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 479

ISBN-13: 3642578586

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Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy, of ionising radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Problems remain with regard to maximizing the effects of hyperthermia as in fluenced by blood flow, heat loss, etc. The present volume defines the current knowledge relative to hyperthermia with radiation therapy and/or chemotherapy, giving a comprehensive overview of its use in cancer management. Philadelphia/Hamburg, June 1995 L.W. BRADY H.-P. HEILMANN Preface In an attempt to overcome tumor resistance, hypoxia, or unfavorable tumor condi tions, oncological research has come to focus on gene therapy, immunotherapy, new cytotoxic agents, and increasingly sophisticated radiotherapy. Radiation research has been directed towards heavy particle therapy and modification of the radiation response by either protecting or sensitizing agents. Improved dose localization using rotational or conformal strategies has also been implemented. Recently, changes in radiation fractionation schedules have shown promise of better results. Hyperthermia in cancer therapy can be viewed similarly as another means to increase the sensitivity of tumors to radio- and chemotherapy.

Thermal Effects on Cells and Tissues
Thermal Effects on Cells and Tissues

Author: M. Urano

Publisher: CRC Press

Published: 2023-01-06

Total Pages: 221

ISBN-13: 146656377X

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Volume 1 of Thermal Effects on Cells and Tissues covers Hyperthermia and Oncology. This is a collection of eight essays.

Hyperthermia and the Therapy of Malignant Tumors
Hyperthermia and the Therapy of Malignant Tumors

Author: Christian Streffer

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 371

ISBN-13: 3642829554

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Tumour therapy depends essentially on being able to destroy the clonogenic activity of tumour cells while keeping the damage to the normal tissue low. Clinical experience shows that tumour response varies greatly even if tumours with the same localisation, clinical, and histopathological staging are compared. Some tumours appear to be resistant to conventional radiotherapy (X-rays, y-rays or fast electrons) or chemotherapy. In these cases new therapy modalities are necessary. Combined therapy modalities seem to have advan tages for some resistant tumours; one possibility of such a treatment is to combine radiotherapy or chemotherapy with hyperthermia. This means that the local tumour, the tumour region or even the whole body of the patient has to be heated to temperatures between 40° to 45° C (in case of whole body hyperthermia to 42° C maximal) for a certain time (usually 30-60 min are adequate). Hyperthermia has a long tradition in medicine as a treatment modality for various diseases. Inscriptions of the old Egyptians and texts of the Greeks have pointed out its importance. Usually whole body hyperthermia has been used by the induction of fever. Local hyperthermia began around 1900 when Westermark treated unre sectable cervix carcinomas with hot water in a metallic coil. By the beginning of this century an increase of radiation effects was hy pothesised with hypothermia and later observed. However, only in the 1960s and 1970s were systematic investigations started which showed radiosensitisation and chemosensitisation by hyperthermia in cells and tissues including tumours.