This PhD thesis focuses on the search for flavor-changing neutral currents in the decay of a top quark to an up-type quark (q = u, c) and the Standard Model Higgs boson, where the Higgs boson decays to bb. Further, the thesis presents the combination of this search for top quark pair events with other ATLAS searches – in the course of which the most restrictive bounds to date on tqH interactions were obtained. Following on from the discovery of the Higgs boson, it is particularly important to measure the Yukawa couplings of the Standard Model fermions; these parameters may provide crucial insights to help solve the flavor puzzle and may help reveal the presence of new physics before it is directly observed in experiments.
Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.
The 28th conference from the Rochester series was the major high energy physics conference in 1996. Volume one contains short reports on new theoretical and experimental results. Volume two consists of the review talks presented in the plenary sessions.
This book reviews the present state of knowledge of the anomalous magnetic moment a=(g-2)/2 of the muon. The muon anomalous magnetic moment is one of the most precisely measured quantities in elementary particle physics and provides one of the most stringent tests of relativistic quantum field theory as a fundamental theoretical framework. It allows for an extremely precise check of the standard model of elementary particles and of its limitations.
This highly-regarded text provides a comprehensive introduction to modern particle physics. Extensively rewritten and updated, this 4th edition includes developments in elementary particle physics, as well as its connections with cosmology and astrophysics. As in previous editions, the balance between experiment and theory is continually emphasised. The stress is on the phenomenological approach and basic theoretical concepts rather than rigorous mathematical detail. Short descriptions are given of some of the key experiments in the field, and how they have influenced our thinking. Although most of the material is presented in the context of the Standard Model of quarks and leptons, the shortcomings of this model and new physics beyond its compass (such as supersymmetry, neutrino mass and oscillations, GUTs and superstrings) are also discussed. The text includes many problems and a detailed and annotated further reading list.
