This thesis describes the stand-alone discovery and measurement of the Higgs boson in its decays to two W bosons using the Run-I ATLAS dataset. This is the most precise measurement of gluon-fusion Higgs boson production and is among the most significant results attained at the LHC. The thesis provides an exceptionally clear exposition on a complicated analysis performed by a large team of researchers. Aspects of the analysis performed by the author are explained in detail; these include new methods for evaluating uncertainties on the jet binning used in the analysis and for estimating the background due to associated production of a W boson and an off-shell photon. The thesis also describes a measurement of the WW cross section, an essential background to Higgs boson production. The primary motivation of the LHC was to prove or disprove the existence of the Higgs boson. In 2012, CERN announced this discovery and the resultant ATLAS publication contained three decay channels: gg, ZZ, and WW.
These proceedings gather invited and contributed talks presented at the XXI DAE-BRNS High Energy Physics Symposium, which was held at the Indian Institute of Technology Guwahati in December 2014. The contributions cover many of the most active research areas in particle physics, namely (i) Electroweak Physics; (ii) QCD and Heavy Ion Physics; (iii) Heavy Flavour Physics and CP Violation; (iv) Neutrino Physics; (v) Astro-particle Physics and Cosmology; (vi) Formal Theory; (vii) Future Colliders and New Machines; and (viii) BSM Physics: SUSY, Extra Dimensions, Composites etc. The DAE-BRNS High Energy Physics Symposium, widely considered to be one of the premiere symposiums organised in India in the field of elementary particle physics, is held every other year and supported by the Board of Research in Nuclear Sciences, Department of Atomic Energy, India. Roughly 250 physicists and researchers participated in the 21st Symposium, discussing the latest advancements in the field in 18 plenary review talks, 15 invited mini-review talks and approximately 130 contributed presentations. Bringing together the essential content, the book offers a valuable resource for both beginning and advanced researchers in the field.
This book provides a comprehensive overview of the field of Higgs boson physics. It offers the first in-depth review of the complete results in connection with the discovery of the Higgs boson at CERN’s Large Hadron Collider and based on the full dataset for the years 2011 to 2012. The fundamental concepts and principles of Higgs physics are introduced and the important searches prior to the advent of the Large Hadron Collider are briefly summarized. Lastly, the discovery and first mensuration of the observed particle in the course of the CMS experiment are discussed in detail and compared to the results obtained in the ATLAS experiment.
'The editors make a good point in claiming the time has come to upgrade the Standard Model into the ‘Standard Theory’ of particle physics, and I think this book deserves a place in the bookshelves of a broad community, from the scientists and engineers who contributed to the progress of high-energy physics to younger physicists, eager to learn and enjoy the corresponding inside stories.'Carlos LourençoCERN CourierThe book gives a quite complete and up-to-date picture of the Standard Theory with an historical perspective, with a collection of articles written by some of the protagonists of present particle physics. The theoretical developments are described together with the most up-to-date experimental tests, including the discovery of the Higgs Boson and the measurement of its mass as well as the most precise measurements of the top mass, giving the reader a complete description of our present understanding of particle physics.
Fundamental interactions are mediated by bosonic fields, quanta of which are realized as particles. The properties of these fields typically obey certain symmetry rules. In this book we discuss the symmetry between two types of interactions — electromagnetic, which are familiar to anyone who turned on the electric lights, and weak, which govern the nuclear reactions that fuel the Sun. While there is a symmetry between these two types of interactions, it is broken. The unified theory of electroweak interactions was developed over 50 years ago. The Higgs scalar field named after one of the theorists that proposed it, is believed to be responsible for the breaking of the electroweak symmetry. Yet, it is only now after the discovery of the Higgs boson in 2012 by the LHC experiments, that we can study the mechanism of the electroweak symmetry breaking. This book discusses the theoretical developments that led to the construction of this theory, the discovery and the experimental observations that need to come to fully establish the validity of the model.
In the field of particle and astrophysics, one of the major unresolved problems is to understand the nature and properties of dark matter, which constitutes almost 80% of the matter content of the universe. This book gives a pedagogical introduction to the field of dark matter in general, and in particular to the model building perspective. Starting from the evidence and need for dark matter, it goes into the deeper understanding of how to accommodate a dark matter candidate in a particle physics model. This book focuses on teaching the basic tools for model building of dark matter, starting from the easiest to gradually the difficult one. Although there are plenty of dark matter models available in the literature, this book concentrates on the important ones. This book aims to motivate the reader to propose a new dark matter model complying with all observational constraints.
Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.
“Overall, this is an excellent book on an important topic in cancer that medical oncologists, pharmacologists, and nurses, as well as related healthcare professionals, may find very helpful.” Score: 100, 5 Stars, Doody’s Medical Reviews Head and Neck Cancers: Evidence-Based Treatment presents a practical, state-of-the-art resource for any clinical oncologist treating or managing patients with head and neck cancers, including oropharyngeal cancer, cancer of the oral cavity, laryngeal cancer, nasopharyngeal cancer, hypopharyngeal cancer, cancer of the sinuses and the skull base, salivary gland cancer, and neck lymphadenopathy. Section 1 of the book covers the most pertinent details on the epidemiology, biology, diagnosis and staging of the disease including topics such as the genomic landscape of squamous cell carcinoma of the head and neck and novel imaging modalities. Section 2 discusses the evidence-based treatment modalities for conventional and novel chemotherapy regimens, the evidence behind emerging radiation therapy techniques and the minimally invasive surgical advances changing the landscape of care. The chapters in Section 3 are dedicated to site-specific management, including management guidelines, tables with FDA-approved therapies and relevant ongoing clinical trials as well as instructive clinical cases with important discussion on outcomes and follow up care. Finally, Section 4 focuses on recurrent and metastatic disease and Section 5 provides the essentials on supportive care, including managing the elderly, managing patients suffering from dysphagia and oral complications, and must-know details of quality of life assessment and patient-reported outcomes. Emphasizing the practice-changing techniques and the latest evidence-based treatment advances including targeted therapies, immunotherapy, transoral robotic surgery, and radiation therapy precision, this comprehensive yet accessible textbook is indispensable for any clinical oncologist of each discipline wanting a balanced and evidence-based reference on managing patients with head and neck malignancies. Key Features: Includes didactic clinical cases for each type of head and neck cancer Numerous tables highlight FDA approved therapies and ongoing clinical trials Provides evidence-based recommendations for treating head and neck cancers at each stage of the disease with conventional and novel treatment strategies Covers strategies for managing acute and late complications to treatment
