Schistosomes and Schistosomiasis in South Asia
Schistosomes and Schistosomiasis in South Asia

Author: Prof. Mahesh Chandra Agrawal

Publisher: Springer Science & Business Media

Published: 2012-05-30

Total Pages: 358

ISBN-13: 8132205391

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According to the author, the book addresses to all the scientists and not only to immunologists or biologists of European countries who are engaged in developing a vaccine, or a diagnostic kit or a new drug against the infection or on schistosome evolution. Even these scientists have to visit endemic countries for field trials or ask their counterparts to collect field data (which this book addresses ). Thus this book is not on molecular fundamentals but on the infection itself; how schistosome species are responding to the drug ; sensitivity and specificity of immunodiagnostic kits, antigen molecules; snail compatibility, production losses; schistosome evolution; schistosome outbreaks; complexities where more than two schistosome species are existing; problem of human schistosomiasis in South Asia etc In fact , all the topics of great interest to international scientists and scientists of endemic countries.

Human Schistosomiasis
Human Schistosomiasis

Author: Peter Jordan

Publisher: Oxford University Press, USA

Published: 1993

Total Pages: 486

ISBN-13:

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Human schistosomes (blood flukes) are digenetic trematodes that spend the adult part of their life cycle in humans and a further part in aquatic snails. Despite advances in chemotherapy, schistosomiasis is still a significant infection in the populations of several countries in the tropics. This book replaces a previous volume Schistosomiasis: Epidemiology, Treatment and Control (Heinemann, 1982) by Jordan and Webbe. All chapters have been rewritten by internationally renowned workers. Ultrasound, expected to aid identification of early disease in the field and increase our understanding of its evolution, is discussed in a new chapter. Others, each with an extensive bibliography, review the parasites and their snail intermediate hosts, epidemiology, clinical manifestations and pathology, diagnosis, immunology, drugs and patient management and control. Limitations of the role of chemotherapy in morbidity control are discussed and the need for flexibility in control interventions in the varied epidemiological situations is stressed. An interdisciplinary approach may be necessary to reduce transmission by appropriate measures against the snail intermediate host, and to implement public health measures, including the provision of safe water (with many other medical and social benefits) and health education. This comprehensive volume is for public health workers involved in the prevention and control of the disease, for physicians, and for students and teachers of many disciplines. It also provides a reference book for health planners, social anthropologists, health educators, water and sanitary engineers and others engaged in improving health in the tropics. Physicians in temperate countries will also find it a useful reference book as schistosomiasis, often acute, is being diagnosed more frequently in those returning from holidays in endemic areas.

Schistosomes, Liver Flukes and Helicobacter Pylori
Schistosomes, Liver Flukes and Helicobacter Pylori

Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Publisher: World Health Organization

Published: 1994

Total Pages: 284

ISBN-13:

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Evaluates the carcinogenic risk to humans posed by infection with three schistosoma trematodes, three liver flukes and the bacterium Helicobacter pylori. These biological agents were selected for evaluation on the basis of evidence suggesting a causal association between infection and the development of human cancers. The first monograph assesses data on Schistosoma haematobium S. mansoniand S. japonicum, the three species which account for the vast majority of schistosomal disease in humans. The most extensive sections evaluate the results of studies of cancer in humans and experimental animals, concentrating on the strength of evidence linking infection with S. haematobium to squamous-cell carcinoma of the urinary bladder, and infection with S. mansoni or S. japonicum to an increased risk for cancers of the gastrointestinal tract. The monograph concludes that infection with S. haematobium is carcinogenic to humans and that infection with S. japonicum is possibly carcinogenic to humans; infection with S. mansoni could not be classified. The second monograph on liver flukes evaluates data on Opisthorchis viverriniO. felineus and Clonorchis sinensis. These foodborne trematodes establish a chronic infection of the bile ducts and more rarely the pancreatic duct and gall-bladder of humans and other mammals. Most carcinogenicity data centre on the possibility that these trematodes are involved in the development of cholangiocarcinoma or liver cancer. The monograph concludes that infection with O. viverrini is carcinogenic to humans and that infection with C. sinensis is probably carcinogenic to humans; infection with O. felineus could not be classified. The final monograph evaluates data on Helicobacter pylori. More than half of the world's population may be infected with this bacterium, which is responsible for most cases of chronic gastritis and duodenal ulcer. Citing several studies linking infection to gastric cancer in humans, the monograph concludes that infection with H. pylori is carcinogenic to humans.

Schistosomes
Schistosomes

Author: Paul Frederick Basch

Publisher: Oxford University Press, USA

Published: 1991

Total Pages: 272

ISBN-13:

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This work provides a unique, comprehensive, and up-to-date review of the biology of the parasitic flatworm, Schistosoma, which is responsible for one of the world's most pervasive infectious diseases, Schistisomiasis. The unusual characteristics of the organism, and the immediacy of its effect on human health, have combined to bring the schistosomes under considerable scrutiny in the field of parasitology. As parasites living within the circulatory systems of their vertebrate hosts, adult schistosomes face problems of reproduction and egg dispersal far beyond those of most animals. Yet despite their many apparent frailties, these organisms have developed mechanisms not only to survive, but to prevail and evolve into dangerous pathogens. This book concentrates on development and reproduction, since they are key to the parasite's existence and are particularly important because the disease in humans is induced by the worms' eggs rather than the organisms themselves. The book will aid those investigators who wish to apply advanced techniques to schistosomes, but who lack familiarity with their fundamental biology. It draws together findings on the main features of schistosome biology, pointing out areas of controversy and special significance, and topics in need of further work. The author is a recognized authority on schistosomiasis. His book will be an invaluable aid to all those involved in studying and treating the disease, including parasitologists, immunologists, molecular biologists, and public health specialists.

Schistosoma
Schistosoma

Author: Barrie G. M. Jamieson

Publisher: CRC Press

Published: 2017-01-12

Total Pages: 524

ISBN-13: 1498744265

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Apart from malaria, schistosomiasis is the most prevalent parasitic infection in the world. It affects more than 200 million people in 76 tropical and subtropical countries, causing great suffering and resulting in thousands of deaths. Written by world authorities, this book examines many aspects of the biology, pathology, and control of the schistosoma parasite. Ranging in topic from infection in Pharaonic Egypt, through DNA relationships and biological systems, to advances in development of vaccines against the parasite, this book is a comprehensive text written for researchers and medical professionals alike.

Gene function in schistosomes: recent advances towards a cure
Gene function in schistosomes: recent advances towards a cure

Author: Arnon Dias Jurberg

Publisher: Frontiers Media SA

Published: 2015-06-17

Total Pages: 156

ISBN-13: 2889195562

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Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection. Despite extensive effort to control this NTD over the years, deployment on a considerable scale of commercially available drugs in endemic populations has induced the emergence of resistant isolates and raised the need to identify new targets for alternative therapies. Because of the availability of genomes of the three major species of human schistosomiasis, and through advances in functional genomics and live imaging, studies on schistosomes have now come into focus as models to investigate adaptations to parasitism and developmental biology of trematodes and cestodes, and indeed flatworms and Lophotrochozoans, at large. This Research Topic aims at gathering state-of-art essays on schistosome genetics, genetics, pathobiology and immunobiology. It also aims to highlight advances in understanding of the host-parasite relationship, in paradigms that address this NTD, and to discuss new perspectives and advances in chemotherapy and immunoprophylaxis.

Schistosomiasis
Schistosomiasis

Author: W. Evan Secor

Publisher: Springer Science & Business Media

Published: 2006-02-10

Total Pages: 242

ISBN-13: 0387233628

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Human schistosomiasis is a disease with a rich and well-documented past, and every expectation of an unfortunately long future. These infections were known to the ancient Egyptians and their transmission shows little evidence of slowing down, globally. The good news is that field applicable, and increasingly affordable, chemotherapy has been available for almost 25 years. Using chemotherapy and other means of control, some countries have decreased transmission and made excellent headway against morbidity. The bad news is that the public health problems caused by schistosomiasis are still with us, with the estimated number of cases of schistosomiasis, while shifting geographically, remaining approximately 200 million for the last 30 years. In fact, with the development of field usable ultrasound technology and meta-analyses performed on existing data, there is a new appreciation for the extent of non-lethal morbidity associated with these infections. While the percentage of individuals with severe hepatosplenic disease remains below 10%, recent reassessments of morbidity associated with schistosomiasis indicate that the prevelance of symptoms and the cost in diability-adjusted life years is much greater than was previously, commonly appreciated (Van der Werf, M. J. , et al. 2003, Acta Tropica 86:125-139; Charles H. King, personnel communication). Strong impetus for addressing these issues is provided by the World Health Assembly’s recently passed Resolution 54. 19, which calls for efforts to reduce morbidity caused by schistosomiasis and soil-transmitted helminths in school-aged children, largely through chemotherapy campaigns.

Molecular Approaches to Parasitology
Molecular Approaches to Parasitology

Author: John C. Boothroyd

Publisher: Wiley-Liss

Published: 1995-02-06

Total Pages: 592

ISBN-13:

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Describes the dramatic advances in the field during the recent past, focusing on the ways in which molecular tools can be used to study the biology of parasites. Reflects the successful transfection of Leishmania, Trypanosoma, Toxoplasma and Plasmodium—a major breakthrough which allowed investigation into a range of new areas. The role of cytokines in immunity to parasites dominates the work on immunology. Also covers entirely new arenas including RNA editing.

Parasitic Flatworms
Parasitic Flatworms

Author: Aaron G. Maule

Publisher: CABI

Published: 2006

Total Pages: 470

ISBN-13: 1845930398

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Parasitic flatworms include Cestodes (tapeworms) and trematodes (flukes, schistosomes, etc) and are the cause of a number of major diseases of medical and veterinary significance. Much recent research has focused on molecular biology and genomics. this book aims to review advances in our understanding of these and related topics such as flatworm biochemistry, immunology and physiology. Where appropriate, comparisons are made between different parasitic flatworms and between parasitic and free-living species. Contributors to the book include leading authorities from Europe, North and South America, and Australia.

Encyclopedia of Parasitology: A-M
Encyclopedia of Parasitology: A-M

Author: Heinz Mehlhorn

Publisher: Springer Science & Business Media

Published: 2007-11-28

Total Pages: 1577

ISBN-13: 3540489940

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Knowledge in the field of parasitology must be kept at a high level and up to date in order to fight a parasitosis as quickly and effectively as possible. The third edition of this, one of Springer’s renowned and authoritative Major Reference Works, contributes to these goals in several ways. First, the number of entries has been increased by about 30%. Secondly the content has been improved even more by adding additional tables and figures. Thirdly, the extensive linking between definitions and essays facilitates information within a minimum of time. More than 40 international contributors, who are well known specialists in their fields, give a comprehensive review of all parasites and therapeutic strategies in veterinarian and human parasitology.