Best Estimate Safety Analysis for Nuclear Power Plants
Best Estimate Safety Analysis for Nuclear Power Plants

Author:

Publisher:

Published: 2008

Total Pages: 216

ISBN-13:

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Deterministic safety analysis is an important tool for confirming the adequacy and efficiency of provisions within the defence in depth concept for the safety of nuclear power plants (NPPs). IAEA Safety Standards Series No. NS-R-1.2 and Safety Reports Series No. 23 recommend, as one of the options for demonstrating the inclusion of adequate safety margins, the use of best estimate computer codes with realistic input data in combination with the evaluation of uncertainties in the calculation results. The evaluation of uncertainties is an issue of considerable complexity, and this Safety Report has been developed to complement the existing publications. It provides more detailed information on the methods available for the evaluation of uncertainties in deterministic safety analysis of NPPs and practical guidance in the use of these methods.

Safety of Existing Dams
Safety of Existing Dams

Author: National Research Council

Publisher: National Academies Press

Published: 1983-01-01

Total Pages: 376

ISBN-13: 0309074797

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Written by civil engineers, dam safety officials, dam owners, geologists, hydraulic engineers, and risk analysts, this handbook is the first cooperative attempt to provide practical solutions to dam problems within the financial constraints faced by dam owners. It provides hands-on information for identifying and remedying common defects in concrete and masonry dams, embankment dams, reservoirs, and related structures. It also includes procedures for monitoring dams and collecting and analyzing data. Case histories demonstrate economical solutions to specific problems.

Format and Content of the Safety Analysis Report for Nuclear Power Plants
Format and Content of the Safety Analysis Report for Nuclear Power Plants

Author: International Atomic Energy Agency

Publisher: IAEA

Published: 2004

Total Pages: 98

ISBN-13:

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This Safety Guide is intended primarily for use with land based stationary thermal nuclear power plants but it may, in parts, have a wider applicability to other nuclear facilities. It provides recommendations and guidance on the possible format and content of a SAR in support of a request to the State regulatory body for authorization to construct and or operate a nuclear power plant. As such, it contains recommendations on meeting the requirements of Safety guide GS-R-1 "Legal and governmental infrastructure for nuclear, radioactive waste and transport safety" (2000, ISBN 9201008007)

Registries for Evaluating Patient Outcomes
Registries for Evaluating Patient Outcomes

Author: Agency for Healthcare Research and Quality/AHRQ

Publisher: Government Printing Office

Published: 2014-04-01

Total Pages: 385

ISBN-13: 1587634333

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This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.

NRC Regulatory Guides
NRC Regulatory Guides

Author: U.S. Nuclear Regulatory Commission

Publisher:

Published: 1973

Total Pages: 32

ISBN-13:

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A compilation of currently available electronic versions of NRC regulatory guides.

Preclinical Safety Evaluation of Biopharmaceuticals
Preclinical Safety Evaluation of Biopharmaceuticals

Author: Joy A. Cavagnaro

Publisher: John Wiley & Sons

Published: 2013-03-07

Total Pages: 1012

ISBN-13: 1118679385

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"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.

Evaluation of the Safety of Operating Nuclear Power Plants Built to Earlier Standards
Evaluation of the Safety of Operating Nuclear Power Plants Built to Earlier Standards

Author: International Atomic Energy Agency

Publisher:

Published: 1998

Total Pages: 106

ISBN-13:

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This Safety Report complements Safety Guide No. 50-SG-O12, Periodic Safety Review of Operational Nuclear Power Plants (1994). It provides practical information for the safety assessment and judgement process for operating nuclear power plants built to earlier standards, on the basis of a comparison with current safety standards and operational practices.

Review of the Draft Fourth National Climate Assessment
Review of the Draft Fourth National Climate Assessment

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2018-06-18

Total Pages: 207

ISBN-13: 0309471699

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Climate change poses many challenges that affect society and the natural world. With these challenges, however, come opportunities to respond. By taking steps to adapt to and mitigate climate change, the risks to society and the impacts of continued climate change can be lessened. The National Climate Assessment, coordinated by the U.S. Global Change Research Program, is a mandated report intended to inform response decisions. Required to be developed every four years, these reports provide the most comprehensive and up-to-date evaluation of climate change impacts available for the United States, making them a unique and important climate change document. The draft Fourth National Climate Assessment (NCA4) report reviewed here addresses a wide range of topics of high importance to the United States and society more broadly, extending from human health and community well-being, to the built environment, to businesses and economies, to ecosystems and natural resources. This report evaluates the draft NCA4 to determine if it meets the requirements of the federal mandate, whether it provides accurate information grounded in the scientific literature, and whether it effectively communicates climate science, impacts, and responses for general audiences including the public, decision makers, and other stakeholders.