Revisiting Seed and Soil: A New Approach to Target Hibernating Dormant Tumor Cells, 2nd edition
Revisiting Seed and Soil: A New Approach to Target Hibernating Dormant Tumor Cells, 2nd edition

Author: Dalit Barkan

Publisher: Frontiers Media SA

Published: 2023-03-07

Total Pages: 158

ISBN-13: 2832512542

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Metastasis is the major cause of mortality in cancer patients. Metastases can be present at the time of diagnosis or can occur years or decades after the removal of the primary tumor and treatment. This long latency in the manifestation of recurrent metastatic disease is explained clinically by the persistence of quiescent tumor cells that disseminated early in the course of the disease from the primary tumor to select distant organs. These residing disseminated tumor cells (DTCs) at distant organs lay dormant and asymptomatic until reawakened to form overt metastases. Importantly, the quiescent nature of these “hibernating” DTCs facilitates their resistance to conventional therapies that target actively dividing tumor cells. Therefore, unraveling the biology of dormancy and reactivation of the residing DTCs to life-threatening lesions is of utmost importance in order to develop new therapeutic strategies to prevent the recurrent metastatic disease from ever emerging or to better treat these recurrent cancers. The mechanisms underlying the biology of tumor dormancy and their reactivation to overt metastases are just beginning to emerge thanks to a growing appreciation of the potentially chronic nature of some cancers and the development of experimental model systems for their study. In this Research Topic, we will follow the journey of circulating tumor cells (CTCs) dispatching from the primary site until their successful lodging into a new and foreign site to become DTCs. We will explore the intrinsic mechanisms along with microenvironmental cues and niches that they encounter during their journey that may dictate their fate.

Medical and Veterinary Entomology
Medical and Veterinary Entomology

Author: Gary R. Mullen

Publisher: Academic Press

Published: 2009-04-22

Total Pages: 646

ISBN-13: 0080919693

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Medical and Veterinary Entomology, Second Edition, has been fully updated and revised to provide the latest information on developments in entomology relating to public health and veterinary importance. Each chapter is structured with the student in mind, organized by the major headings of Taxonomy, Morphology, Life History, Behavior and Ecology, Public Health and Veterinary Importance, and Prevention and Control. This second edition includes separate chapters devoted to each of the taxonomic groups of insects and arachnids of medical or veterinary concern, including spiders, scorpions, mites, and ticks. Internationally recognized editors Mullen and Durden include extensive coverage of both medical and veterinary entomological importance. This book is designed for teaching and research faculty in medical and veterinary schools that provide a course in vector borne diseases and medical entomology; parasitologists, entomologists, and government scientists responsible for oversight and monitoring of insect vector borne diseases; and medical and veterinary school libraries and libraries at institutions with strong programs in entomology. Follows in the tradition of Herm's Medical and Veterinary Entomology The latest information on developments in entomology relating to public health and veterinary importance Two separate indexes for enhanced searchability: Taxonomic and Subject New to this edition: Three new chapters Morphological Adaptations of Parasitic Arthropods Forensic Entomology Molecular Tools in Medical and Veterinary Entomology 1700 word glossary Appendix of Arthropod-Related Viruses of Medical-Veterinary Importance Numerous new full-color images, illustrations and maps throughout

Intermountain Alfalfa Management
Intermountain Alfalfa Management

Author: Steve B. Orloff

Publisher: UCANR Publications

Published: 1997-06-01

Total Pages: 152

ISBN-13: 9781879906242

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This comprehensive guide for western alfalfa growers brings together the most current information and recommendations in nearly all areas of alfalfa management, including stand establishment, fertilization, irrigation, pest management, and harvesting

Biochemistry of Collagens, Laminins and Elastin
Biochemistry of Collagens, Laminins and Elastin

Author: Morten Karsdal

Publisher: Academic Press

Published: 2016-07-29

Total Pages: 274

ISBN-13: 0128098996

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Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. - Provides a comprehensive introduction to collagen and structural proteins - Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation - Includes a chapter dedicated to the biomarkers of structural proteins - Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Archaeology, Anthropology, and Interstellar Communication
Archaeology, Anthropology, and Interstellar Communication

Author: National Aeronautics Administration

Publisher: CreateSpace

Published: 2014-09-06

Total Pages: 332

ISBN-13: 9781501081729

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Addressing a field that has been dominated by astronomers, physicists, engineers, and computer scientists, the contributors to this collection raise questions that may have been overlooked by physical scientists about the ease of establishing meaningful communication with an extraterrestrial intelligence. These scholars are grappling with some of the enormous challenges that will face humanity if an information-rich signal emanating from another world is detected. By drawing on issues at the core of contemporary archaeology and anthropology, we can be much better prepared for contact with an extraterrestrial civilization, should that day ever come.

Insect Diapause
Insect Diapause

Author: David L. Denlinger

Publisher: Cambridge University Press

Published: 2022-02-03

Total Pages: 465

ISBN-13: 1108755186

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Our highly seasonal world restricts insect activity to brief portions of the year. This feature necessitates a sophisticated interpretation of seasonal changes and enactment of mechanisms for bringing development to a halt and then reinitiating it when the inimical season is past. The dormant state of diapause serves to bridge the unfavourable seasons, and its timing provides a powerful mechanism for synchronizing insect development. This book explores how seasonal signals are monitored and used by insects to enact specific molecular pathways that generate the diapause phenotype. The broad perspective offered here scales from the ecological to the molecular and thus provides a comprehensive view of this exciting and vibrant research field, offering insights on topics ranging from pest management, evolution, speciation, climate change and disease transmission, to human health, as well as analogies with other forms of invertebrate dormancy and mammalian hibernation.

Edible Insects
Edible Insects

Author: Arnold van Huis

Publisher: Bright Sparks

Published: 2013

Total Pages: 0

ISBN-13: 9789251075951

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Edible insects have always been a part of human diets, but in some societies there remains a degree of disdain and disgust for their consumption. Although the majority of consumed insects are gathered in forest habitats, mass-rearing systems are being developed in many countries. Insects offer a significant opportunity to merge traditional knowledge and modern science to improve human food security worldwide. This publication describes the contribution of insects to food security and examines future prospects for raising insects at a commercial scale to improve food and feed production, diversify diets, and support livelihoods in both developing and developed countries. It shows the many traditional and potential new uses of insects for direct human consumption and the opportunities for and constraints to farming them for food and feed. It examines the body of research on issues such as insect nutrition and food safety, the use of insects as animal feed, and the processing and preservation of insects and their products. It highlights the need to develop a regulatory framework to govern the use of insects for food security. And it presents case studies and examples from around the world. Edible insects are a promising alternative to the conventional production of meat, either for direct human consumption or for indirect use as feedstock. To fully realise this potential, much work needs to be done by a wide range of stakeholders. This publication will boost awareness of the many valuable roles that insects play in sustaining nature and human life, and it will stimulate debate on the expansion of the use of insects as food and feed.

The Potato Crop
The Potato Crop

Author: Hugo Campos

Publisher: Springer Nature

Published: 2019-12-03

Total Pages: 524

ISBN-13: 3030286835

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This book is open access under a CC BY 4.0 license. This book provides a fresh, updated and science-based perspective on the current status and prospects of the diverse array of topics related to the potato, and was written by distinguished scientists with hands-on global experience in research aspects related to potato. The potato is the third most important global food crop in terms of consumption. Being the only vegetatively propagated species among the world’s main five staple crops creates both issues and opportunities for the potato: on the one hand, this constrains the speed of its geographic expansion and its options for international commercialization and distribution when compared with commodity crops such as maize, wheat or rice. On the other, it provides an effective insulation against speculation and unforeseen spikes in commodity prices, since the potato does not represent a good traded on global markets. These two factors highlight the underappreciated and underrated role of the potato as a dependable nutrition security crop, one that can mitigate turmoil in world food supply and demand and political instability in some developing countries. Increasingly, the global role of the potato has expanded from a profitable crop in developing countries to a crop providing income and nutrition security in developing ones. This book will appeal to academics and students of crop sciences, but also policy makers and other stakeholders involved in the potato and its contribution to humankind’s food security.

Introduction to Plant Diseases
Introduction to Plant Diseases

Author: George B. Lucas

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 374

ISBN-13: 1461572940

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Every year we see a remarkable increase in scientific knowledge. We are learning more each day about the world around us, about the numerous biological organisms of the biosphere, about the physical and chemical processes that shaped and continue to change our planet. The cataloging, retrieval, dissemination, and use of this new information along with the continued development of new computer technology provide some of the most challenging problems in science as we enter the Information Age. With the explosion of knowledge in science, it is especially important that students in introductory courses learn not only the basic material of a subject, but also about the newest developments in that subject. With this goal in mind, we have prepared a second edition of Introduction to Plant Diseases: Identification and Management. We prepared this edition with the same general purpose that we had for the first edition - to provide practical, up-to-date information that helps in the successful management of diseases on food, fiber, and landscape plants for students who do not have a strong background in the biological sciences. We included new information on (1) the precise identification of diseases and the pathogens that cause them, (2) the development of epidemics of plant diseases, (3) the application of biotechnology in plant pathology, (4) the use of alternative methods of crop production and disease management that help protect the environment, and (5) diseases that have become more important since the first edition was published.

Bio-Inspired Innovation and National Security
Bio-Inspired Innovation and National Security

Author: National Defense University

Publisher: NDU Press

Published: 2010-10

Total Pages: 356

ISBN-13: 1780390408

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Despite the vital importance of the emerging area of biotechnology and its role in defense planning and policymaking, no definitive book has been written on the topic for the defense policymaker, the military student, and the private-sector bioscientist interested in the "emerging opportunities market" of national security. This edited volume is intended to help close this gap and provide the necessary backdrop for thinking strategically about biology in defense planning and policymaking. This volume is about applications of the biological sciences, here called "biologically inspired innovations," to the military. Rather than treating biology as a series of threats to be dealt with, such innovations generally approach the biological sciences as a set of opportunities for the military to gain strategic advantage over adversaries. These opportunities range from looking at everything from genes to brains, from enhancing human performance to creating renewable energy, from sensing the environment around us to harnessing its power.