[Reviews of Physiology, Biochemistry, and Pharmacology, Volume 146> Text reviews four research abstracts. Discusses tumor-inhibiting platinum complexes, protein targeting, transport of organic anions, and molecular basis of skeletal muscle plasticity.
Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Some of the most serious consequences of aging are its effects on skeletal muscle. ‘Sarcopenia’, the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence. Not surprisingly, sarcopenia is a significant public health problem throughout the developed world. There is an urgent need to better understand the neuromuscular mechanisms underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or ultimately reverse sarcopenia. Significant research and development in academic and research institutions and in pharmaceutical companies is being directed to sarcopenia and to related health issues in order to develop and evaluate novel therapeutics. This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders. The book provides a vital resource for researchers and practitioners alike, with information relevant to gerontologists, geriatricians, sports medicine physicians, physiologists, neuroscientists, cell biologists, endocrinologists, physical therapists, allied health and musculoskeletal practitioners, strength and conditioning specialists, athletic trainers, and students of the medical and biomedical sciences.
The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
Advanced Neuromuscular Exercise Physiology uses a mix of biochemistry, molecular biology, neurophysiology, and muscle physiology to provide a synthesis of current knowledge and research directions in the field. The first text devoted solely to the topic, Advanced Neuromuscular Exercise Physiology assists readers in identifying current directions in research and new avenues for exploration. Recognizing the rapid changes occurring in the field of neuromuscular exercise physiology, the text provides readers with a foundation of knowledge while detailing the most recent findings. Though the text is written at an advanced level, the author succeeds at making the content accessible. Analyses of research findings and research applications are highlighted in special sidebars. Detailed illustrations and graphs assist readers in understanding research findings. Chapter summaries also help readers determine the key issues presented for each topic. The author draws attention to a variety of important topics in the field, beginning with a discussion of motor unit types, muscle blood flow, and metabolic pathways in control of metabolism, including a special discussion of the effects of type 2 diabetes. Next, the topic of fatigue is discussed. The author explains possible peripheral and central contributors to fatigue. Chapters 6 and 7 focus on whole-body endurance training, including the effects of aerobic endurance training on the protein profiles of muscle fibers and on the central nervous system. Of particular interest is the applicability of research information to the exercise rehabilitation of individuals with compromised nervous system function, such as spinal cord injury, other trauma, and neuromuscular diseases. The final chapters are devoted to resistance training, including the phenotypic responses of muscles to isometric, slow isotonic, lengthening, and plyometric training. An overview of the effects of resistance training on the nervous system is offered along with clinical applications. Within the dynamic field of neuromuscular exercise physiology, ideas of how nerves and muscles collaborate during acute and chronic exercise are continually evolving. Advanced Neuromuscular Exercise Physiology offers an authoritative perspective of current research in the field as it seeks to encourage discussion, further study, and new research directions. Human Kinetics’ Advanced Exercise Physiology Series offers books for advanced undergraduate and graduate students as well as professionals in exercise science and kinesiology. These books highlight the complex interaction of the various systems both at rest and during exercise. Each text in this series offers a concise explanation of the system and details how each is affected by acute exercise and chronic exercise training. Advanced Neuromuscular Exercise Physiology is the third volume in the series.