Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

Author: Philip K. Moore

Publisher: Springer

Published: 2015-07-10

Total Pages: 384

ISBN-13: 3319181440

DOWNLOAD EBOOK

This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.


Reviews of Physiology, Biochemistry and Pharmacology 176

Reviews of Physiology, Biochemistry and Pharmacology 176

Author: Pieter de Tombe

Publisher: Springer

Published: 2019-04-02

Total Pages: 134

ISBN-13: 303014027X

DOWNLOAD EBOOK

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.


Pharmacology of Ganglionic Transmission

Pharmacology of Ganglionic Transmission

Author: D.A. Kharkevich

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 536

ISBN-13: 364267397X

DOWNLOAD EBOOK

D.A. KHARKEVICH The history of the study of ganglionic substances begins with the paper of LANGLEY and DICKINSON (1889), who established the ability of nicotine to block the neurones in the superior cervical ganglion. This was a considerable discovery as the authors ascertained that impulses were transmitted from pre- to postganglionic neurones in the autonomic ganglia. Simultaneously they indicated the possibility of pharmaco logical influence upon interneuronal transmission in autonomic ganglia. The idea of ganglionic receptors specifically sensitive to nicotine followed logically. Later, LANGLEY (1905, 1906) considered the problem of receptors with respect to neuro-effector synapses. It is remarkable that he was one of the first to put forward the theory of chemical mediation of excitation (" ... the nervous impulse should not pass from nerve to muscle by an electric discharge, but by the secretion of a special substance at the end of the nerve": LANGLEY, 1906, p. 183). In addition, LANGLEY JOHN N. LANGLEY (1852-1926) D.A. KHARKEVICH 2 and his collaborators managed to define the topography of autonomic ganglia more precisely by means of nicotine. It should be mentioned that it was he who introduced the terms "autonomic nervous system" and "parasympathetic nervous system".


Reviews of Physiology, Biochemistry and Pharmacology 158

Reviews of Physiology, Biochemistry and Pharmacology 158

Author: S.G. Amara

Publisher: Springer Science & Business Media

Published: 2007-05-17

Total Pages: 164

ISBN-13: 3540717919

DOWNLOAD EBOOK

Contents E.I. Christensen and R. Nielsen: Role of Megalin and Cubilin in Renal Physiology and Pathophysiology G. Zifarelli and M. Pusch: CLC Chloride Channels and Transporters: A Biophysical and Physiological Perspective S.F.J. van de Graaf, R.J.M. Bindels and J.G.J. Hoenderop: Physiology of Epithelial Ca2 and Mg2+ Transport


Hand and Brain

Hand and Brain

Author:

Publisher: Elsevier

Published: 1996-06-24

Total Pages: 535

ISBN-13: 0080532748

DOWNLOAD EBOOK

Used for gestures of communication, environmental exploration, and the grasping and manipulating of objects, the hand has a vital role in our lives. The hand's anatomical structure and neural control are among the most complex and detailed of human motor systems.Hand and Brain is a comprehensive overview of the hand's sensorimotor control. It discusses mediating variables in perception and prehension, the coordination of muscles with the central nervous system, the nature of movement control and hand positioning, hand-arm coordination in reaching and grasping, and the sensory function of the hand.In the last decade the rapid growth of neuroscience has been paralleled by a surge of interest in hand function. This reflects the fact that many of the fundamental issues facing neuroscientists today--including the problem of relating physiology to behavior--are central to the study of sensorimotor control of the hand. This book takes a broad interdisciplinary perspective on the control of hand movements that includes neurophysiology, neuroanatomy, psychology and neuropsychology, and biomechanics.The authors, who have all made significant scientific contributions in their own right, have sought to introduce their chosen topics in a manner that the undergraduate reader will be able to follow without sacrificing detailed and up-to-date coverage ofthe major developments.Uses an interdisciplinary approach including behavioral and neurophysiological dataDescribes a variety of experimental methodologiesTreats neural computations necessary for the control of movementCovers implications of biomechanics for control, sensory mechanisms, and perceptual processing (haptics)Includes manipulative hand function as well as reachingOverviews each group of chapters using link sectionsContains an integrated index and a glosssaryThe five sections cover:Mediating variables in perception and prehensionThe coordination of muscles with the central nervous systemThe nature of movement control and hand positioningHand-arm coordination in reaching and graspingThe sensory function of the hand


Concepts and Principles of Pharmacology

Concepts and Principles of Pharmacology

Author: James E. Barrett

Publisher: Springer Nature

Published: 2019-12-24

Total Pages: 457

ISBN-13: 3030353621

DOWNLOAD EBOOK

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.