Read and Download eBook Full
Author: Jay Schulkin
Publisher: MIT Press
Published: 2003
Total Pages: 332
ISBN-13: 9780262194808
DOWNLOAD EBOOKAn overview of allostasis, the process by which the body maintains overall viability under normal and adverse conditions.
Author: Nicholas Mrosovsky
Publisher: New York : Oxford University Press
Published: 1990
Total Pages: 200
ISBN-13:
DOWNLOAD EBOOKThis work offers a comprehensive re-examination and elaboration of homeostasis, a guiding principle in physiology that has received surprisingly little critical evaluation. Among the key topics addressed are questions concerning the competing demands of different regulatory systems within the body and the problem of maintaining equilibrium in such circumstances. The author makes the important point that the body does not always seek constancy of its internal environment, nor does it always react in ways that prevent change. On the contrary, sometimes physiological mechanisms actively promote change. These changes in regulated levels--termed "rheostasis"--are seen as having an adaptive value beyond a simple failure of homeostasis. This book compares and categorizes examples of rheostasis for a variety of physiological variables, and presents what is known about conflicts between different regulatory systems and their role in promoting the occurrence of rheostasis. Among other topics covered are weight loss during hibernation, calcium storage and reproduction, fever, and rates of fat deposition in adults. The work of an outstanding scholar, this integrative study represents a refreshing and essential new approach to one of the basic concepts in physiological science.
Author: Angel L. Pey
Publisher: Academic Press
Published: 2020-02-13
Total Pages: 452
ISBN-13: 0128191333
DOWNLOAD EBOOKProtein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. - Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands - Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease - Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance
Author: David Sarokin
Publisher: MIT Press
Published: 2016-08-26
Total Pages: 261
ISBN-13: 0262034921
DOWNLOAD EBOOKHow better information and better access to it improves the quality of our decisions and makes for a more vibrant participatory society. Information is power. It drives commerce, protects nations, and forms the backbone of systems that range from health care to high finance. Yet despite the avalanche of data available in today's information age, neither institutions nor individuals get the information they truly need to make well-informed decisions. Faulty information and sub-optimal decision-making create an imbalance of power that is exaggerated as governments and corporations amass enormous databases on each of us. Who has more power: the government, in possession of uncounted terabytes of data (some of it obtained by cybersnooping), or the ordinary citizen, trying to get in touch with a government agency? In Missed Information, David Sarokin and Jay Schulkin explore information—not information technology, but information itself—as a central part of our lives and institutions. They show that providing better information and better access to it improves the quality of our decisions and makes for a more vibrant participatory society. Sarokin and Schulkin argue that freely flowing information helps systems run more efficiently and that incomplete information does just the opposite. It's easier to comparison shop for microwave ovens than for doctors or hospitals because of information gaps that hinder the entire health-care system. Better information about such social ills as child labor and pollution can help consumers support more sustainable products. The authors examine the opacity of corporate annual reports, the impenetrability of government secrets, and emerging techniques of “information foraging.” The information imbalance of power can be reconfigured, they argue, with greater and more meaningful transparency from government and corporations.
Author: Jay Schulkin
Publisher: Cambridge University Press
Published: 2004-10-25
Total Pages: 388
ISBN-13: 1316347702
DOWNLOAD EBOOKThe concept of homeostasis, the maintenance of the internal physiological environment of an organism within tolerable limits, is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. With allostatic regulation by cephalic involvement, the body adapts to potentially diverse and dangerous situations through the activation of neural, hormonal, or immunological mechanisms. Allostasis explains how regulatory events maintain organismic viability, or not, in diverse contexts with varying set points of bodily needs and competing motivations. This 2005 book introduces the concept of allostasis and sets it alongside traditional views of homeostasis. It addresses basic regulatory systems and examines the behavior of bodily regulation under duress. The basic concepts of physiological homeostasis are integrated with disorders like depression, stress, anxiety and addiction. It will therefore appeal to graduate students, medical students and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.
Author: Gabriel Abraham Almond
Publisher: Princeton University Press
Published: 2015-12-08
Total Pages: 575
ISBN-13: 1400874564
DOWNLOAD EBOOKThe authors interviewed over 5,000 citizens in Germany, Italy, Mexico, Great Britain, and the U.S. to learn political attitudes in modem democratic states. Originally published in 1963. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Author: Jay Schulkin
Publisher: JHU Press
Published: 2020-03-03
Total Pages: 208
ISBN-13: 1421429373
DOWNLOAD EBOOKIn the first half of the twentieth century, psychology was a discipline in search of scientific legitimacy. Debates raged over how much of human and animal behavior is instinctive and how much is learned, and how behavior could be quantified accurately. At the Johns Hopkins University's new Phipps Psychiatric Clinic, Curt P. Richter stood aside from these heated theoretical arguments, choosing instead to apply his data-collection methods, innovative measurement techniques, playful sense of exploration, and consummate surgical skill to laboratory examinations of the biological basis of behavior. From identifying the biological clocks that govern behavior and physiology to observing the self-regulation of nutrient levels by the body, the cyclical nature of some mental illnesses, and the causes of hopelessness, Richter's wide-ranging discoveries not only influenced the burgeoning field of psychobiology and paved the way for later researchers but also often had implications for the treatment of patients in the clinic. At the time of his death in 1988, Richter left behind a massive collection of laboratory data. For this book, Jay Schulkin mined six decades of Richter's archived research data, personal documents, and interviews to flesh out an engaging portrait of a "laboratory artisan" in the context of his work.
Author: Harold L. Miller, Jr.
Publisher: SAGE Publications
Published: 2016-01-05
Total Pages: 1173
ISBN-13: 1506340105
DOWNLOAD EBOOKDrawing together a team of international scholars, The SAGE Encyclopedia of Theory in Psychology examines the contemporary landscape of all the key theories and theorists, presenting them in the context needed to understand their strengths and weaknesses. Key features include: · Approximately 300 signed entries fill two volumes · Entries are followed by Cross-References and Further Readings · A Reader′s Guide in the front matter groups entries thematically · A detailed Index and the Cross-References provide for effective search-and-browse in the electronic version · Back matter includes a Chronology of theory within the field of psychology, a Master Bibliography, and an annotated Resource Guide to classic books in this field, journals, associations, and their websites The SAGE Encyclopedia of Theory in Psychology is an exceptional and scholarly source for researching the theory of psychology, making it a must-have reference for all academic libraries.
Author: Jay Michael Hanes
Publisher: Routledge
Published: 2018-06-12
Total Pages: 288
ISBN-13: 1351801295
DOWNLOAD EBOOKGrounded in philosophy from John Dewey and Maxine Greene, this book sheds light on difficulties and practicalities of examining culture and politics within the realm of interdisciplinary education. Providing both theoretical and concrete examples of the importance of a contemporary arts education, this book offers imaginative ways the arts and sciences intersect with democratic learning and civic engagement. Chapters focus on education in relation to diversity, apprenticeship, and civic engagement; neuroscience and cognition; urban aesthetic experience and learning; and science and art intelligence.
Author: Randolph M. Nesse, MD
Publisher: Penguin
Published: 2019-02-12
Total Pages: 386
ISBN-13: 1101985682
DOWNLOAD EBOOKA founder of the field of evolutionary medicine uses his decades of experience as a psychiatrist to provide a much-needed new framework for making sense of mental illness. Why do I feel bad? There is real power in understanding our bad feelings. With his classic Why We Get Sick, Dr. Randolph Nesse helped to establish the field of evolutionary medicine. Now he returns with a book that transforms our understanding of mental disorders by exploring a fundamentally new question. Instead of asking why certain people suffer from mental illness, Nesse asks why natural selection has left us all with fragile minds. Drawing on revealing stories from his own clinical practice and insights from evolutionary biology, Nesse shows how negative emotions are useful in certain situations, yet can become overwhelming. Anxiety protects us from harm in the face of danger, but false alarms are inevitable. Low moods prevent us from wasting effort in pursuit of unreachable goals, but they often escalate into pathological depression. Other mental disorders, such as addiction and anorexia, result from the mismatch between modern environment and our ancient human past. And there are good evolutionary reasons for sexual disorders and for why genes for schizophrenia persist. Taken together, these and many more insights help to explain the pervasiveness of human suffering, and show us new paths for relieving it by understanding individuals as individuals.
