Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research

Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research

Author: Helmut Sinzinger

Publisher: Springer Science & Business Media

Published: 2013-11-11

Total Pages: 447

ISBN-13: 1489918108

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The International Symposium on Prostaglandins and Related Compounds, first held in Vienna 1972, revisited the city after 24 years for the 10TH Symposium. For the many re searchers working in this multi-disciplinary field it was an opportunity to exchange their ex periences and share new data with colleagues from all around the world. This scientific exchange was largely encouraged by the unseasonably cold and rainy weather. For the first time, there was quite a large attendance from the former Communist countries. Eugene Garfield prepared a key note address delivered during the meeting (The Sci entist 1996, 12) reviewing the contribution of the Nobel Laureates U.S. von Euler, l.R. Vane, S.K. Bergstrom, and B.I. Samuelsson, discussing the relevance of the more than 40,000 pa pers in this area published since 1991. Overall, there is still a rapidly growing interest, and in particular a great variety of clinical applications of this family of compounds which were dis cussed in detail during the meeting. Beside the lectures there were 19 workshops covering nearly all the topics of key in terest. All the speakers were invited to prepare a manuscript which has resulted in the volume now in your hands. Special thanks to Dr. Patrick Wong and the new publisher of this series who helped to publish the proceedings in the usual quality and reasonable period of time. Looking forward to seeing all of you again in Florence in 1999, hopefully with much more sun.


Prostaglandins, Leukotrienes, Lipoxins, and PAF

Prostaglandins, Leukotrienes, Lipoxins, and PAF

Author: J. Martyn Bailey

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 453

ISBN-13: 1489907270

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Proceedings of the XIth International Washington Spring Symposium at the George Washington University, held in Washington, D.C., May 13-17, 1991


The Eicosanoids

The Eicosanoids

Author: Peter Curtis-Prior

Publisher: John Wiley & Sons

Published: 2004-07-16

Total Pages: 654

ISBN-13: 047002061X

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This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).


Development of Anti-Asthma Drugs

Development of Anti-Asthma Drugs

Author: Derek R. Buckle

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 416

ISBN-13: 1483192474

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Development of Anti-Asthma Drugs reviews existing asthma treatments and novel approaches currently under investigation, in the context of their mode of action and clinical effectiveness, in the hope that this might lead to a greater understanding of the factors involved in the expression of the disease and, therefore, in the design of better drugs. It is planned based on the concept of the causes and treatment of asthma, This book is organized in three main parts. Part I deals with the nature of asthma, its pathological mechanisms, natural history and epidemiology. Part II discusses mediators associated with asthma including platelet-activating factor, leukotrienes and histamine. Part II covers pharmaceutical approaches in the development of anti-asthma drugs and includes sections on inhibitors of mediator release and competitive and functional antagonists. This book will be of interest to persons dealing with studies on anti-asthma drugs and those interested in pharmacological development.


Prostacyclin and Its Stable Analogue, Iloprost

Prostacyclin and Its Stable Analogue, Iloprost

Author: Ryszard Gryglewski

Publisher: Springer

Published: 1987

Total Pages: 344

ISBN-13:

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Ten years after the discovery of prostacyclin, our knowledge of its biochemical mode of action, pharmacological properties, pathophysiological significance and therapeutic applications is ever expanding. Prostacyclin is both complex and unique as demonstrated by its unusual feature of being chemically and meta bolically unstable when compared to other prostanoids and known amine or peptide mediators. Although physiologically essential, the chemical instability of prostacyclin poses a serious drawback in laboratory and clinical studies. It is one of the genuine objectives of pharmaceutical research to supply synthetic compounds which overcome the inherent drawbacks - considering investigational and therapeutic use - of endogenous compounds. Whereas metabolic instability in certain cases could be of advantage, chemical instability definitely is not. With Iloprost, a molecule has been designed which - according to all data so far available - pertains high receptor affinity, metabolic instability (clinically this equates with a fine control of Iloprost's effects) while chemical stability has been achieved. By virtue of these characteristics Iloprost can be considered as one step towards specific interaction within the arachidonic acid cascade, namely the prostacyclin receptor. The aim of the symposium was to provide a critical experimental appraisal concerning the biochemical mode of action and pharmacological properties of prostacyclin and Iloprost.


Current Catalog

Current Catalog

Author: National Library of Medicine (U.S.)

Publisher:

Published: 1983

Total Pages: 1442

ISBN-13:

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First multi-year cumulation covers six years: 1965-70.


List of Journals Indexed in Index Medicus

List of Journals Indexed in Index Medicus

Author: National Library of Medicine (U.S.)

Publisher:

Published: 1996

Total Pages: 244

ISBN-13:

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Issues for 1977-1979 include also Special List journals being indexed in cooperation with other institutions. Citations from these journals appear in other MEDLARS bibliographies and in MEDLING, but not in Index medicus.


Alicyclic Compounds

Alicyclic Compounds

Author: Malcolm Sainsbury

Publisher: Elsevier

Published: 2016-06-24

Total Pages: 541

ISBN-13: 1483144607

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Rodd's Chemistry of Carbon Compounds, Volume II: Alicyclic Compounds surveys advances in the chemistry of three- to six-membered monocarbocycles from 1973 to 1991. This book begins with a detailed review of the conformations and stereochemical analyses of alicycles, including higher members of the series, and then proceeds to deal with the chemistry of individual ring systems. The next chapters cover the prostaglandins and their allies and natural products bearing a cyclohexane, cyclohexene, or cyclohexadiene ring system. A review of the chemistry of the cyclohexadienes and their metallic complexes is provided at the end. This text also includes a list of common abbreviations and symbols. This volume benefits chemical engineering students, particularly those studying the components of organic chemicals.