Penile Carcinoma

Penile Carcinoma

Author: Philippe E. Spiess

Publisher: Springer Nature

Published: 2021-09-22

Total Pages: 156

ISBN-13: 3030820602

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This book provides a comprehensive and state-of the-art approach to caring for penile carcinoma patients and provides foundational information related to the molecular pathways implicated in penile carcinogenesis and progression. Penile carcinoma remains one of the most debilitating and life-altering malignancies to affect men, with significant impacts on quality of life, erectile function/sexual activity, and length of life. This book illuminates recent advances in penile cancer sparing treatment approaches and oncologically appropriate therapeutic options that help to maintain quality of life, sexual function, and intimacy for patients. It also elucidates recent understandings of human papilloma virus (HPV) and non-HPV driven pathways, which are suspected to have distinct treatment responses and prognoses. The book explores the management of inguinal lymph nodes in the setting of penile cancer, which can now be managed with the integration of key surgical principles/techniques including the adoption of minimally invasive surgery. Considering a multidisciplinary treatment approach for patients exhibiting either locally advanced or more widespread metastatic disease, the book introduces novel systemic therapies currently in development. Further, this book raises clinician awareness of the significant psychosocial impact of penile carcinoma on patients and their families. Penile Carcinoma: Therapeutic Principles and Advances provides readers with the necessary knowledge and insight to care for penile cancer patients with the use of truly state-of-the-art diagnostic and therapeutic approaches. Cancer patients and their families will greatly benefit from adoption of these principles and the accessibility of such advances to their personalized care.


Federal Power Commission Reports

Federal Power Commission Reports

Author: United States. Federal Power Commission

Publisher:

Published: 1975

Total Pages: 1824

ISBN-13:

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Contains all the formal opinions and accompanying orders of the Federal Power Commission ... In addition to the formal opinions, there have been included intermediate decisions which have become final and selected orders of the Commission issued during such period.


Surgical Pathology of the Head and Neck

Surgical Pathology of the Head and Neck

Author: Leon Barnes

Publisher: CRC Press

Published: 2019-01-15

Total Pages: 1800

ISBN-13: 1420020374

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Surgical Pathology of the Head and Neck, Third Edition is a complete stand-alone reference covering all aspects of head and neck pathology. Providing an interdisciplinary approach to the diagnosis, treatment, and management of head and neck diseases, this source promotes clear communication between pathologists and surgeons. This is the reference o


Biomarkers and Immunotherapy for Genitourinary Tumors

Biomarkers and Immunotherapy for Genitourinary Tumors

Author: Hui Dai

Publisher: Frontiers Media SA

Published: 2024-04-02

Total Pages: 374

ISBN-13: 2832547109

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Genitourinary tumors consist of a large variety of malignancies located in the urinary and the reproductive systems, mainly including prostate cancer, bladder cancer, and renal tumors. Apart from surgeries, various systemic treatments have been used for the whole-course management of genitourinary tumors, including radiation therapy, chemotherapy, and hormonal therapy. However, the characteristics of progression, metastasis, and drug resistance deriving from tumors require and breed novel treatments. Furthermore, exploring biomarkers of genitourinary tumors at the early stage is also beneficial to strengthen the management of patients with tumors. Additionally, the diagnostic and prognostic value of the potential biomarkers for immunotherapy and combined therapy of genitourinary tumors are underexplored. On the basis of precision treatments, the advent of immune-based therapies, including immune checkpoint inhibitors (ICIs, antibodies targeting PD-L1 /PD-1 and CTLA-4 pathways), tumor vaccines, and other therapies, has extended the scope of treatment modalities. FDA has until now approved the clinical application of immune checkpoint inhibitors in a wide range of diseases including some types of genitourinary tumors, whereas not all patients with genitourinary tumors are suitable for immune-based therapies, therefore, the understanding of its underlying mechanism is key to develop effective treatments based on current ICI-based immunotherapy.


Advances in Penile and Testicular Cancer, An Issue of Urologic Clinics, E-Book

Advances in Penile and Testicular Cancer, An Issue of Urologic Clinics, E-Book

Author: Jeffrey M. Holzbeierlein

Publisher: Elsevier Health Sciences

Published: 2024-06-26

Total Pages: 145

ISBN-13: 0443246874

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In this issue of Urologic Clinics of North America, guest editors Drs. Jeffrey M. Holzbeierlein and Philippe E. Spiess bring their considerable expertise to the topic of Advances in Penile and Testicular Cancer. Top experts in the field provide important clinical updates on the management of penile and scrotal cancer, discuss the current standards of care using evidence-based treatment guidelines, and provide insight on emerging discoveries. This issue provides critical information and updates needed to improve outcomes in patients with diseases that urologists do not see on a daily basis. - Contains 12 relevant, practice-oriented topics, including the psychosocial impact of penile cancer: an unmet need; what is on the horizon in clinical trials for penile and testicular cancer; the use of miRNA to predict teratoma and viable GCT after chemotherapy; testicular cancers survivorship and fertility preservation; and more. - Provides in-depth clinical reviews on advances in penile and testicular cancer, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.