Protein Kinase D Signaling Through Substrate Phosphorylation in Endocytic Trafficking
Protein Kinase D Signaling Through Substrate Phosphorylation in Endocytic Trafficking

Author: Claudine Virginie Cohick

Publisher:

Published: 2011

Total Pages: 248

ISBN-13:

DOWNLOAD EBOOK

Recently, studies have emerged which describe a role for PKD endocytic trafficking. PKD mediates signals through platelet-derived growth factor (PDGF) to control the recycling of [alpha]v[beta]3 integrin (Woods et al., 2004). Here, we use a PKD substrate-directed phosphorylation-specific antibody (PKD pMOTIF) to identify Rabaptin-5 as a novel signaling effector of PKD. PKD phosphorylation of Rabaptin-5 is required for PDGF-induced [alpha]v[beta]3 integrin recycling. Additionally, we report that the PKD-Rabaptin-5 signaling pathway controls the persistent migration of fibroblasts. These findings provide a mechanism by which PKD-regulated trafficking extends to the endocytic compartment and exerts controls over processes required for cell motility.

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Author: Venkataramana K Sidhaye

Publisher: Academic Press

Published: 2017-03-09

Total Pages: 277

ISBN-13: 0128038810

DOWNLOAD EBOOK

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

Protein Kinase D Signaling Through Substrate Phosphorylation
Protein Kinase D Signaling Through Substrate Phosphorylation

Author: Sokha Nhek

Publisher:

Published: 2009

Total Pages: 370

ISBN-13:

DOWNLOAD EBOOK

By combining in vitro biochemical and in silico screening approaches with the substrate-directed PKD pMOTIF antibody, we were able to identify oxysterol-binding protein (OSBP) and signal-induced proliferation-associated 1-like protein 1 (SIPA1L1) as novel PKD substrates. PKD phosphorylation of OSBP inhibits its 25-hydroxycholesterol-induced Golgi localization. These findings reveal PKD as the first identified upstream kinase to regulate OSBP localization. 25OH- mediated OSBP localization regulates sphingomyelin synthesis, demonstrating an additional mechanism in which PKD regulates Golgi lipid homeostasis. PKD phosphorylation of SIPA1L1 and binding through a PDZ domain-interaction regulates SIPA1L1 proteasomal degradation. The cellular abundance of SIPA1L1 protein is critical to its function in E6-induced mammary epithelial cell transformation and neuronal cell morphology, thus implicating PKD in regulation of these biological processes.

Protein Kinase Functions
Protein Kinase Functions

Author: James Robert Woodgett

Publisher: Oxford University Press, USA

Published: 2000

Total Pages: 382

ISBN-13: 9780199637706

DOWNLOAD EBOOK

Since the publication of Protein Kinases in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been dramatic advances in our understanding of the cellular functions of this remarkably diverse class of proteins. Protein Kinase Functions is not just an update of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the recent advances in kinase biology. Chapters on genetic approaches to protein kinase functions, the MAP kinase pathway, and cyclin-dependent kinases have been completely updated and new topics covered in depth are: phosphatidylinositol 3-kinase signalling, JAK-STAT signalling, suppression of tyrosine kinases by the SOCS family proteins, the TGF� superfamily, and the involvement of protein kinases in response to DNA damage. Throughout, emphasis is placed not on individual kinases, but on the functional aspects of the whole system and the relationship between processes and molecules. It is the aim of Protein Kinase Functions to enable the reader to assimilate, compare, and integrate the molecular machinery used by cells to co-ordinate and respond to their environments.

Protein Kinase-mediated Decisions Between Life and Death
Protein Kinase-mediated Decisions Between Life and Death

Author: Ayse Basak Engin

Publisher: Springer Nature

Published: 2021-02-04

Total Pages: 415

ISBN-13: 3030498441

DOWNLOAD EBOOK

Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Signaling Mechanisms Regulating T Cell Diversity and Function
Signaling Mechanisms Regulating T Cell Diversity and Function

Author: Jonathan Soboloff

Publisher: CRC Press

Published: 2017-03-27

Total Pages: 258

ISBN-13: 149870509X

DOWNLOAD EBOOK

T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Protein Kinases and Stress Signaling in Plants
Protein Kinases and Stress Signaling in Plants

Author: Girdhar K. Pandey

Publisher: John Wiley & Sons

Published: 2020-12-03

Total Pages: 560

ISBN-13: 1119541565

DOWNLOAD EBOOK

A comprehensive review of stress signaling in plants using genomics and functional genomic approaches Improving agricultural production and meeting the needs of a rapidly growing global population requires crop systems capable of overcoming environmental stresses. Understanding the role of different signaling components in plant stress regulation is vital to developing crops which can withstand abiotic and biotic stresses without loss of crop yield and productivity. Emphasizing genomics and functional genomic approaches, Protein Kinases and Stress Signaling in Plants is a comprehensive review of cutting-edge research on stress perception, signal transduction, and stress response generation. Detailed chapters cover a broad range of topics central to improving agricultural production developing crop systems capable of overcoming environmental stresses to meet the needs of a rapidly growing global population. This book describes the field of protein kinases and stress signaling with a special emphasis on functional genomics. It presents a highly valuable contribution in the field of stress perception, signal transduction and generation of responses against one or multiple stress signals. This timely resource: Summarizes the role of various kinases involved in stress management Enumerates the role of TOR, GSK3-like kinase, SnRK kinases in different physiological conditions Examines mitogen-activated protein kinases (MAPKs) in different stresses Describes the different aspects of calcium signaling under different stress conditions Examines photo-activated kinases (PAPKs) in varying light conditions Briefs the presence of tyrosine kinases in plants Highlights the cellular functions of receptor ]like protein kinases (RLKs) Possible implication of these kinases in developing stress tolerant crops Protein Kinases and Stress Signaling in Plants: Functional Genomic Perspective is an essential resource for researchers and students in the fields of plant molecular biology and signal transduction, plant responses to stress, plant cell signaling, plant protein kinases, plant biotechnology, transgenic plants and stress biology.