I TECHNOLOGIES -- Hydrogels and polymers as components of a lab on a chip -- Microreplication technologies for polymer-based æTAS applications -- Silicon and glass micromachining for æTAS -- Surface chemistry in polymer microfluidic systems -- Plastic microfluidic devices: electrokinetic manipulations, life science applications, and production technologies -- II METHODS -- Transverse diffusion in microfluidic systems -- Nanoliter & picoliter liquid handling -- Micro sequential injection system for monitoring of metabolites extruded by cultured cells -- III CELL- & BEAD-BASED SYSTEMS -- Handling of beads in microfluidic devices for biotech applications -- Particles and molecules handling in micro channels -- Cell counting and cell sizing in microstructures -- IV APPLICATIONS -- Microfabricated capillary array electrophoresis: -- implementation and applications -- Microfluidic systems for analysis of the proteome with mass spectrometry -- Interfacing æTAS to matrix assisted laser desorpt ...
In the past ten years there has been a rapid growth of the research and application area known as Lab-on-a-Chip. After an initial focus on electrokinetic separation techniques on chip, the scope of the field has widened to include topics like microfluidics, DNA analysis, cell analysis, microreactors and mass spectrometer interfacing. As well as the analytical chemistry community, synthetic chemists, chemical engineers, biochemists and biomedical engineers are now also becoming more and more interested in using new micro- and nanotechnological techniques. This first Lab-on-a-Chip book contains a broad collection of papers on microtechnology, microfluidics, analytical methods and applications. All contributions are written by leading researchers in their respective fields, and provide new scientists with an overview of the field, to make him/her aware of the enormous opportunities offered by modern technology. The work presented in this book will definitely stimulate readers to new ideas and concepts, and lead to further innovations in this area. - Provides a quick introduction into the different aspects of this field - Describes technology that has already revolutionized the world of chemical and biochemical analysis and synthesis - All contributions are written by leading researchers in their respective fields
The current interest in developing novel materials has motivated an increasing need for biological and medical studies in a variety of dinical applications. Indeed, it is dear that to achieve the requisite mechanical, chemical and biomedical properties, especially for new bioactive materials, it is necessary to develop novel synthesis routes. The tremendous success of materials science in developing new biomaterials and fostering technological innovation arises from its focus on interdisciplinary research and collaboration between materials and medical sciences. Materials scientists seek to relate one natural phenomenon to the basic structures of the materials and to recognize the causes and effects of the phenomena. In this way, they have developed explanations for the changing of the properties, the reactions of the materials to the environment, the interface behaviors between the artificial materials and human tissue, the time effects on the materials, and many other natural occurrences. By the same means, medical scientists have also studied the biological and medical effects of these materials, and generated the knowledge needed to produce useful medical devices. The concept of biomaterials is one of the most important ideas ever generated by the application of materials science to the medical field. In traditional materials research, interest focuses primarilyon the synthesis , structure, and mechanical properties of materials commonly used for structural purposes in industry, for instance in mechanical parts of machinery.
Conservation and Restoration of Glass is an in-depth guide to the materials and practices required for the care and preservation of glass objects. It provides thorough coverage of both theoretical and practical aspects of glass conservation. This new edition of Newton and Davison's original book, Conservation of Glass, includes sections on the nature of glass, the historical development and technology of glassmaking, and the deterioration of glass. Professional conservators will welcome the inclusion of recommendations for examination and documentation. Incorporating treatment of both excavated glass and historic and decorative glass, the book provides the knowledge required by conservators and restorers and is invaluable for anyone with glass objects in their care.