Preparative and Production Scale Chromatography
Preparative and Production Scale Chromatography

Author: G. Ganetsos

Publisher: CRC Press

Published: 2019-11-11

Total Pages: 812

ISBN-13: 100072350X

DOWNLOAD EBOOK

Describes the latest developments in the scaling-up and application of chromatographic operations and demonstrates that production-scale chromatography is a powerful and invaluable separation process. The book covers every important process design and reveals actual, immediately applicable techniques and is designed to appeal to design, chemical/biochemical, and research and development engineers, process development managers, bioprocess technologists, analytical and clinical chemists and biochemists, pharmacists, and upper-level undergraduate, graduate, and continuing-education students in these disciplines.

Preparative Scale Chromatography
Preparative Scale Chromatography

Author: Eli Grushka

Publisher: CRC Press

Published: 1988-10-28

Total Pages: 352

ISBN-13: 9780824780616

DOWNLOAD EBOOK

Discusses a model for the propagation of a finite concentration zone in a chromatographic column for the case of a single component sample, and explores operating conditions of ion-exchange chromatography for the production of albumin from bovine serum and plasma. Focus is on theoretical, instrument

Preparative Chromatography
Preparative Chromatography

Author: H. Schmidt-Traub

Publisher: John Wiley & Sons

Published: 2006-03-06

Total Pages: 485

ISBN-13: 3527605908

DOWNLOAD EBOOK

This interdisciplinary approach combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes. The book covers recent developments in preparative chromatographic processes for the separation of "smaller" molecules using standard laboratory equipment as well as the detailed conception of industrial chemical plants. Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on solid materials and packed columns process concepts. Final chapters on modeling and determination of model parameters, the design and optimization of preparative chromatographic processes and chromatographic reactors allow for the optimum selection of chromatographic systems. Essential for chemists and engineers working in the chemicals and pharmaceutical industries as well as for food technologies, due to the interdisciplinary nature of these processes.

Preparative Chromatography for Separation of Proteins
Preparative Chromatography for Separation of Proteins

Author: Arne Staby

Publisher: John Wiley & Sons

Published: 2017-02-02

Total Pages: 608

ISBN-13: 1119031176

DOWNLOAD EBOOK

Preparative Chromatography for Separation of Proteins addresses a wide range of modeling, techniques, strategies, and case studies of industrial separation of proteins and peptides. • Covers broad aspects of preparative chromatography with a unique combination of academic and industrial perspectives • Presents Combines modeling with compliantce useing of Quality-by-Design (QbD) approaches including modeling • Features a variety of chromatographic case studies not readily accessible to the general public • Represents an essential reference resource for academic, industrial, and pharmaceutical researchers

Scale-Up and Optimization in Preparative Chromatography
Scale-Up and Optimization in Preparative Chromatography

Author: Anurag Rathore

Publisher: CRC Press

Published: 2002-09-26

Total Pages: 368

ISBN-13: 9780203909287

DOWNLOAD EBOOK

Presenting guidelines to predict and improve separation system performance, this book contains numerous case studies illustrating the practice of scale-up principles in process development. It offers solutions to limitations that occur in real-world purification schemes; methods to model, optimize, and characterize nonlinear separation processes; d

A Practical Handbook of Preparative HPLC
A Practical Handbook of Preparative HPLC

Author: Donald A Wellings

Publisher: Elsevier

Published: 2011-04-18

Total Pages: 193

ISBN-13: 0080458858

DOWNLOAD EBOOK

This book is a distillation of twenty years of practical experience of the high pressure liquid chromatography (HPLC) process. Deliberately steering clear of complex theoretical aspects, this book concentrates on the everyday problems associated with the technique, making it perfect for frequent use in the laboratory and for those in the pharmaceutical, agrochemical and biotechnology industries for the analysis and purification of drugs, small molecules, proteins and DNA.This book...•Provides practical, hands-on advice based on years of experience•Will help ensure optimal design, equipment and separation results for your particular task•Presents system layouts from laboratory to process scale•Will help you to devise or improve record-keeping and documentation systems ·Provides practical, hands-on advice based on years of experience·Will help ensure optimal design, equipment and separation results for your particular task·Presents system layouts from laboratory to process scale·Will help you to devise or improve record-keeping and documentation systems

Preparative Enantioselective Chromatography
Preparative Enantioselective Chromatography

Author: Geoffrey B. Cox

Publisher: John Wiley & Sons

Published: 2008-04-15

Total Pages: 344

ISBN-13: 1405144718

DOWNLOAD EBOOK

The development of chiral liquid chromatography, facilitating thestraightforward separation of enantiomers, was a significantadvance in chromatography, leading to widespread application inanalytical chemistry. Application in preparative chromatography hasbeen less rapid, but with the development of single enantiomerpharmaceuticals its use is increasingly common in chemicalsynthesis at laboratory, pilot plant and even full productionscale. Brings non-experts up to speed quickly and comprehensively,facilitating the rapid development of effective separations ofenantiomeric mixtures on a range of process scales Presents case studies drawn from within the pharmaceuticalindustry to clearly illustrate the utility and value of preparativescale enantioselective chromatography in chemical research,development and production Key reference source and entry to the literature so the readerdoes not have to engage in expensive and time consuming literaturesearching

Preparative Liquid Chromatography
Preparative Liquid Chromatography

Author: B.A. Bidlingmeyer

Publisher: Elsevier

Published: 1987-07-01

Total Pages: 357

ISBN-13: 0080858414

DOWNLOAD EBOOK

This volume provides a straightforward approach to isolation and purification problems with a thorough presentation of preparative LC strategy including the interrelationship between the input and output of the instrumentation, while keeping to an application focus.The book stresses the practical aspects of preparative scale separations from TLC isolations through various laboratory scale column separations to very large scale production. It also gives a thorough description of the performance parameters (e.g. throughput, separation quality, etc.) as a function of operational parameters (e.g. particle size, column size, solvent usage, etc.). Experts in the field have contributed a well balanced presentation of separation development strategies from preparative TLC to commercial preparative process with practical examples in a wide variety of application areas such as drugs, proteins, nucleotides, industrial extracts, organic chemicals, enantiomers, polymers, etc.

Preparative Chromatography
Preparative Chromatography

Author: H. Schmidt-Traub

Publisher: John Wiley & Sons

Published: 2012-09-27

Total Pages: 545

ISBN-13: 3527649301

DOWNLOAD EBOOK

Completely revised and substantially extended to reflect the developments in this fast-changing field. It retains the interdisciplinary approach that elegantly combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes. It also covers recent advances in preparative chromatographic processes for the separation of "smaller" molecules using standard laboratory equipment as well as the detailed conception of industrial chemical plants. The increase in biopharmaceutical substances is reflected by new and revised chapters on different modifications of continuous chromatography as well as ion-exchange chromatography and other separation principles widely used in biochromatography. Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on stationary phases, selection of chromatographic systems and process concepts. A completely new chapter deals with engineering and operation of chromatographic equipment. Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes. Essential for chemists and chemical engineers in the chemical, pharmaceutical, and food industries.

Preparative Scale Chromatography
Preparative Scale Chromatography

Author: Eli Grushka

Publisher: CRC Press

Published: 1988-10-28

Total Pages: 344

ISBN-13: 9780824780616

DOWNLOAD EBOOK

Discusses a model for the propagation of a finite concentration zone in a chromatographic column for the case of a single component sample, and explores operating conditions of ion-exchange chromatography for the production of albumin from bovine serum and plasma. Focus is on theoretical, instrument