At last, an answer to the question that has bedeviled trainers for decades. Predictive evaluation enables you to effectively and accurately forecast training's value to your company, measure against these predictions, establish indicators to track your progress, make midcourse corrections, and report the results in a language that business executives respond to and understand. Dave Basarab explains how to begin by identifying the specific goals and beliefs you want to instill in participants. The next step is to determine exactly what these will look like when put into action. Finally you develop quantifiable measures of how employees' adopting the target beliefs and goals will impact the business. A key strength of this process is that it is profoundly collaborative—supervisors and employees work together to establish standards for success each step of the way. A how-to guide filled with worksheets, examples, and other tools, Predictive Evaluation ensures that, rather than being regarded as an expense and an act of faith, training will be seen as an investment with a concrete payoff.
This work supports a process called Predictive Evaluation (PE) which enables practitioners to provide executives with compelling training data around the success of training in the three areas of Intention, Adoption, and Impact. PEalso works to determine whether success has been achieved, and provides lead indicators of future adoption (transfer...
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens.
A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means .. can give rise to toxicity in animals and human beings, and that they must be subjected to controls. The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes tament, controls have existed[l]. In the Middle Ages Paracelsus (1493-1541) noted that "All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing a poison", and hence he stressed the importance of dose relative to toxic reactions [ 2] . Most of the early controls concentrated on substances that were to be deliberately administered to the human subject in the form of medicines. Legislation for many centuries was mainly con cerned with regulating the activities of apothecaries and physicians. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. Among the controls which it exerted was that over the use of medicinal substances. Such controls were, however, poor, based as they were on hearsay evidence of toxicity. For many centuries no means existed for the accurate determination of toxicity.
Precision medicine is an emerging practice by which clinicians aim to deliver a personalized treatment program to affected patients based on information gained from their individual clinical and biological profiles. In the context of precise cancer immunotherapy, multi-omics, high-throughput sequencing, big data, and other approaches serve to screen new predictive factors for immunotherapy response and prognosis in cancer patients.
Statistical evaluation of diagnostic performance in general and Receiver Operating Characteristic (ROC) analysis in particular are important for assessing the performance of medical tests and statistical classifiers, as well as for evaluating predictive models or algorithms. This book presents innovative approaches in ROC analysis, which are releva
Step-by-step guide to build high performing predictive applications Key FeaturesUse the Python data analytics ecosystem to implement end-to-end predictive analytics projectsExplore advanced predictive modeling algorithms with an emphasis on theory with intuitive explanationsLearn to deploy a predictive model's results as an interactive applicationBook Description Predictive analytics is an applied field that employs a variety of quantitative methods using data to make predictions. It involves much more than just throwing data onto a computer to build a model. This book provides practical coverage to help you understand the most important concepts of predictive analytics. Using practical, step-by-step examples, we build predictive analytics solutions while using cutting-edge Python tools and packages. The book's step-by-step approach starts by defining the problem and moves on to identifying relevant data. We will also be performing data preparation, exploring and visualizing relationships, building models, tuning, evaluating, and deploying model. Each stage has relevant practical examples and efficient Python code. You will work with models such as KNN, Random Forests, and neural networks using the most important libraries in Python's data science stack: NumPy, Pandas, Matplotlib, Seaborn, Keras, Dash, and so on. In addition to hands-on code examples, you will find intuitive explanations of the inner workings of the main techniques and algorithms used in predictive analytics. By the end of this book, you will be all set to build high-performance predictive analytics solutions using Python programming. What you will learnGet to grips with the main concepts and principles of predictive analyticsLearn about the stages involved in producing complete predictive analytics solutionsUnderstand how to define a problem, propose a solution, and prepare a datasetUse visualizations to explore relationships and gain insights into the datasetLearn to build regression and classification models using scikit-learnUse Keras to build powerful neural network models that produce accurate predictionsLearn to serve a model's predictions as a web applicationWho this book is for This book is for data analysts, data scientists, data engineers, and Python developers who want to learn about predictive modeling and would like to implement predictive analytics solutions using Python's data stack. People from other backgrounds who would like to enter this exciting field will greatly benefit from reading this book. All you need is to be proficient in Python programming and have a basic understanding of statistics and college-level algebra.
This volume presents the thoroughly revised proceedings of the ICSE '94 Workshop on Joint Research Issues in Software Engineering and Human-Computer Interaction, held in Sorrento, Italy in May 1994. In harmony with the main objectives of the Workshop, this book essentially contributes to establishing a sound common platform for exchange and cooperation among researchers and design professionals from the SE and HCI communities. The book includes survey papers by leading experts as well as focused submitted papers. Among the topics covered are design, processes, user interface technology and SE environments, platform independence, prototyping, interactive behaviour, CSCW, and others.
In this rich, entertaining primer, former Columbia University professor and Predictive Analytics World founder Eric Siegel reveals the power and perils of prediction: What type of mortgage risk Chase Bank predicted before the recession. Predicting which people will drop out of school, cancel a subscription, or get divorced before they are even aware of it themselves. Why early retirement decreases life expectancy and vegetarians miss fewer flights. Five reasons why organizations predict death, including one health insurance company. A truly omnipresent science, predictive analytics affects everyone, every day. Although largely unseen, it drives millions of decisions, determining whom to call, mail, investigate, incarcerate, set up on a date, or medicate. Predictive analytics transcends human perception. This book's final chapter answers the riddle: What often happens to you that cannot be witnessed, and that you can't even be sure has happened afterward -- but that can be predicted in advance? Whether you are a consumer of it -- or consumed by it -- get a handle on the power of Predictive Analytics. This book is easily understood by all readers. Rather than a "how to" for hands-on techies, the book entices lay-readers and experts alike by covering new case studies and the latest state-of-the-art techniques.
