Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.
Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.
Applications of Polymers in Drug Delivery, Second Edition, provides a comprehensive resource for anyone looking to understand how polymeric materials can be applied to current, new, and emerging drug delivery applications. Polymers play a crucial role in modulating drug delivery and have been fundamental in the successful development of many novel drug delivery systems. This book describes the development of polymeric systems, ranging from conventional dosage forms to the most recent smart systems. Regulatory and intellectual property aspects as well as the clinical applicability of polymeric drug delivery systems are also discussed. The chapters are organized by specific delivery route, offering methodical and detailed coverage throughout. This second edition has been thoroughly revised to include the latest developments in the field. This is an essential book for researchers, scientists, and advanced students, in polymer science, drug delivery, pharmacology/pharmaceuticals, materials science, tissue engineering, nanomedicine, chemistry, and biology. In industry, this book supports scientists, R&D, and other professionals, working on polymers for drug delivery applications. - Explains how polymers can be prepared and utilized for all major drug delivery routes - Presents the latest advances, including drug targeting, polymeric micelles and polymersomes, and the delivery of biologicals and nucleic acid therapeutics - Includes appendices with in-depth information on pharmaceutical properties of polymers and regulatory aspects
Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.
Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. - Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring - Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area - Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS
The concept of controlled release has attracted increasing attention over the last two decades, with the applications of this technology proliferating in diverse fields in cluding medicine, agriculture and biotechnology. Research and developmental efforts related to controlled release are multiplying in both industry and academia. The reason for this phenomenal growth is obvious. The use of a variety of biologically active agents, such as drugs, fertilizers and pesticides, has become an integral part of modern society. Along with the use of these reagents has evolved an awareness that their uncontrolled application almost inevitably induces harmful effects on the health of humans and their surrounding environments. To eliminate or minimize these harmful effects necessitates the controlled release of these chemicals. Moreover, the controlled release of substances, not usually considered toxic or hazardous, e.g., some catalysts and nutrients, can enhance their effectiveness. The number and variety of controlled release systems, differing in their physical and chemical makeup, are increasing rapidly. Proliferation almost always demands correlation, generalization and unification; it requires both the development of underlying theories of their behavior and the mechanistic interpretation of their performance. This, in turn, requires a statistical and mathematical (quantitative) treatment of the scientific information and technical data pertaining to them. A quantitative treatment can also facilitate the formulation of procedures for computer-aided design of these systems through a priori prediction of their per formance for a variety of design parameters.
Natural polymers have been utilized extensively in food, pharmaceuticals, cosmetics, textiles, oil drilling and paint industries. Their non-toxic and inexpensive attributes readily enhance their commercial acceptability and make them potent agents in lieu of synthetic polymers. This book explores the opportunistic utility of natural polymers in developing effective drug delivery systems and provides a comprehensive and up-to-date analysis of their source, chemical structure and mechanism of action. Covering novel polymers for drug delivery - in particular extracts from plants, microorganisms and proteins, as well as water soluble and water insoluble biodegradable polymers - it presents an encyclopaedic overview of natural polymers'. Natural Polymers for Drug Delivery is an invaluable resource for researchers, students and industrial scientists in the fields of biochemistry, chemistry, pharmacology and food science.
The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules! Discussing the advantages and limitations of controlled release systems, the Handbook of Pharmaceutical Controlled Release Technology covers oral, transdermal, parenteral, and implantable delivery of drugs discusses modification methods to achieve desired release kinetics highlights constraints of system design for practical clinical application analyzes diffusion equations and mathematical modeling considers environmental acceptance and tissue compatibility of biopolymeric systems for biologically active agents evaluates polymers as drug delivery carriers describes peptide, protein, micro-, and nanoparticulate release systems examines the cost, comfort, disease control, side effects, and patient compliance of numerous delivery systems and devices and more!
Clay–Polymer Nanocomposites is a complete summary of the existing knowledge on this topic, from the basic concepts of synthesis and design to their applications in timely topics such as high-performance composites, environment, and energy issues. This book covers many aspects of synthesis such as in- situ polymerization within the interlamellar spacing of the clays or by reaction of pristine or pre-modified clays with reactive polymers and prepolymers. Indeed, nanocomposites can be prepared at industrial scale by melt mixing. Regardless the synthesis method, much is said in this book about the importance of theclay pre-modification step, which is demonstrated to be effective, on many occasions, in obtaining exfoliated nanocomposites. Clay–Polymer Nanocomposites reports the background to numerous characterization methods including solid state NMR, neutron scattering, diffraction and vibrational techniques as well as surface analytical methods, namely XPS, inverse gas chromatography and nitrogen adsorption to probe surface composition, wetting and textural/structural properties. Although not described in dedicated chapters, numerous X-ray diffraction patterns of clay–polymer nanocomposites and reference materials are displayed to account for the effects of intercalation and exfoliations of layered aluminosilicates. Finally, multiscale molecular simulation protocols are presenting for predicting morphologies and properties of nanostructured polymer systems with industrial relevance. As far as applications are concerned, Clay–Polymer Nanocomposites examines structural composites such as clay–epoxy and clay–biopolymers, the use of clay–polymer nanocomposites as reactive nanocomposite fillers, catalytic clay-(conductive) polymers and similar nanocomposites for the uptake of hazardous compounds or for controlled drug release, antibacterial applications, energy storage, and more. - The most comprehensive coverage of the state of the art in clay–polymer nanocomposites, from synthesis and design to opportunities and applications - Covers the various methods of characterization of clay–polymer nanocomposites - including spectroscopy, thermal analyses, and X-ray diffraction - Includes a discussion of a range of application areas, including biomedicine, energy storage, biofouling resistance, and more
This book contains the proceedings of the International Symposium on Ophthalmie Drug Delivery, which was held in Pisa in October 1986. Topical ophthalmic therapy is a matter of interest to specialists from different fields (medical, pharmaceutical, chemical, technological, etc.), who, unfortunately, have a tendency to meet separately, thus limiting a diffusion of knowledge, ideas and experience that would greatly favour the overall pro gress in this area of research. The Symposium, for the first time in Europe, provided the opportunity for specialists from different disciplines and from different countfies to meet, to discuss and to share their experience. This multidisciplinary approach is reflected in the wide variety of topics that appear in the book. The papers are aimed at reviewing many of the complex, interrelated, medical pharmaceutical and technological facets of topical ophthalmic therapy. lt is our hope that they may stimulate further thought in this fascinating field, and may provide possible guidelines for future research. The editors wish to express their appreciation to the sponsors of the Symposium: Fidia Research Laboratories, whose generosity permitted the meeting tobe held, and the ltalian National Research Council (CNR, Progetto Finalizzato Chimica Fine e Secondaria) who gave its scientific tutorship. Thanks are also due to the other Symposium contributors, ACRAF SpA, Rome, and Allergan Italia SpA, Rome. The assistance, support and coopera tion given before, during and after the Symposium by Dr. Patrizia Chetoni, Dr. Maria Tilde Torracca and Dr. Elena Parolini arealso gratefully acknowledged.
